Association of RFC1 A80G and MTHFR C677T polymorphisms with Alzheimer's disease

Abstract We examined polymorphisms in reduced folate carrier gene ( RFC1 ) and methylenetetrahydrofolate reductase gene ( MTHFR ) for association with sporadic AD (SAD) in Chinese population. Significant associations of RFC1 A80G G allele and GG genotype with SAD ( p = 0.008, OR = 1.312, 95%CI = 1.0...

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Veröffentlicht in:	Neurobiology of aging 2009-10, Vol.30 (10), p.1601-1607
Hauptverfasser:	Bi, Xiu-Hua, Zhao, Hua-Lu, Zhang, Zhen-Xin, Zhang, Jun-Wu
Format:	Artikel
Sprache:	eng
Schlagworte:	5,10-Methylenetetrahydrofolate reductase gene ( MTHFR) Aged Aged, 80 and over Aging Alzheimer Disease - blood Alzheimer Disease - epidemiology Alzheimer Disease - genetics Alzheimer's diseases Apolipoprotein E gene ( APOE) Apolipoprotein E4 - genetics Biological and medical sciences China - epidemiology Chinese Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Development. Senescence. Regeneration. Transplantation Female Folate Folic Acid - blood Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Genome-Wide Association Study Genotype Homocysteine Homocysteine - blood Humans Internal Medicine Male Medical sciences Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged Neurology Polymorphism, Single Nucleotide Polymorphisms Reduced folate carrier gene ( RFC1) Reduced Folate Carrier Protein - genetics Risk Factors Sex Factors Vertebrates: nervous system and sense organs
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