Regulation of Unr expression by 5'- and 3'-untranslated regions of its mRNA through modulation of stability and IRES mediated translation

Unr (upstream of N-ras) is a cytoplasmic RNA-binding protein that can act as a regulator of mRNA stability and IRES-mediated translation. Unr, a member of the cold-shock domain (CSD) protein super-family, is ubiquitously expressed, with variable abundance, in different tissues or during embryonic de...

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Veröffentlicht in:	RNA biology 2005-07, Vol.2 (3), p.e27-e35
Hauptverfasser:	Dormoy-Raclet, Virginie, Markovits, Judith, Jacquemin-Sablon, Alain, Jacquemin-Sablon, Hélène
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - physiology 5' Untranslated Regions - physiology Amino Acid Sequence Animals Base Sequence Binding Sites - physiology Cell Line Gene Expression Regulation - physiology Mice Molecular Sequence Data Poly(A)-Binding Proteins - biosynthesis Poly(A)-Binding Proteins - genetics RNA Stability - physiology RNA, Messenger - physiology
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