Structure–activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors

Structure–activity relationships were determined for three series of pantothenamide-type pantothenate kinase inhibitors through their evaluation in vivo against a panel of four PanK enzymes and for antimicrobial activity. A set of novel pantothenamide-type analogues of the known Staphylococcus aureu...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2006-02, Vol.14 (4), p.1007-1020
Hauptverfasser:	Virga, Kristopher G., Zhang, Yong-Mei, Leonardi, Roberta, Ivey, Robert A., Hevener, Kirk, Park, Hee-Won, Jackowski, Suzanne, Rock, Charles O., Lee, Richard E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Aspergillus nidulans Binding Sites Biological and medical sciences Coenzyme A Escherichia coli Escherichia coli - drug effects Escherichia coli - enzymology Fatty acid synthase General aspects Medical sciences Microbial Sensitivity Tests Models, Molecular Pantothenamide Pantothenate kinase Pharmacology. Drug treatments Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors Phosphotransferases (Alcohol Group Acceptor) - chemistry Phosphotransferases (Alcohol Group Acceptor) - metabolism Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Protein Structure, Tertiary Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - enzymology Structure based drug design Structure-Activity Relationship
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