Evaluation of the Role of Hexokinase Type II in Cellular Proliferation and Apoptosis Using Human Hepatocellular Carcinoma Cell Lines

The (18)F-FDG uptake pattern on PET could be an indicator of the prognosis and aggressiveness of various tumors, including hepatocellular carcinoma (HCC). Hexokinase, especially hexokinase type II (HKII), plays a critical role in (18)F-FDG uptake in rapidly growing tumors. We established a stable ce...

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Veröffentlicht in:	Journal of Nuclear Medicine 2009-09, Vol.50 (9), p.1525-1532
Hauptverfasser:	Ahn, Keun Jae, Hwang, Hee Sung, Park, Jeon Han, Bang, Seong Hye, Kang, Won Jun, Yun, Mijin, Lee, Jong Doo
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - enzymology Cell Line, Tumor Cell Proliferation Fluorodeoxyglucose F18 - pharmacokinetics Hexokinase - metabolism Humans Liver Neoplasms - diagnostic imaging Liver Neoplasms - enzymology Radionuclide Imaging Radiopharmaceuticals - pharmacokinetics
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