Neonatal screening for congenital cytomegalovirus infection and hearing loss
Congenital cytomegalovirus infection causes 20–30% of congenital sensorineural hearing loss (SNHL) cases. Early identification of CMV attributable cases and their successful treatment are often hampered by the late appearance of the damage in a high proportion of children both symptomatic and asympt...
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Veröffentlicht in: | Journal of clinical virology 2006-02, Vol.35 (2), p.206-209 |
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description | Congenital cytomegalovirus infection causes 20–30% of congenital sensorineural hearing loss (SNHL) cases. Early identification of CMV attributable cases and their successful treatment are often hampered by the late appearance of the damage in a high proportion of children both symptomatic and asymptomatic at birth.
To discuss the feasibility of a screening program aimed at finding congenitally infected babies followed by their audiological monitoring.
Opinion—review article.
Frequency and severity of hearing loss due to congenital CMV suggest it maybe worthwhile setting up neonatal screening campaigns. Structures where SNHL can be diagnosed and treated exist already in many countries as part of universal neonatal audiological screening schemes. A test based on viral DNA extraction from neonatal dried blood spots on Guthrie cards and its amplification by means of a nested PCR (DBS test) seems to offer the best characteristics for use in screening. Clearly it will be necessary to calculate whether the costs of screening, diagnosis and follow-up, and the financial and emotional burden on the families of infected children, are up to the potential gain. |
doi_str_mv | 10.1016/j.jcv.2005.08.010 |
format | Article |
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To discuss the feasibility of a screening program aimed at finding congenitally infected babies followed by their audiological monitoring.
Opinion—review article.
Frequency and severity of hearing loss due to congenital CMV suggest it maybe worthwhile setting up neonatal screening campaigns. Structures where SNHL can be diagnosed and treated exist already in many countries as part of universal neonatal audiological screening schemes. A test based on viral DNA extraction from neonatal dried blood spots on Guthrie cards and its amplification by means of a nested PCR (DBS test) seems to offer the best characteristics for use in screening. Clearly it will be necessary to calculate whether the costs of screening, diagnosis and follow-up, and the financial and emotional burden on the families of infected children, are up to the potential gain.</description><identifier>ISSN: 1386-6532</identifier><identifier>EISSN: 1873-5967</identifier><identifier>DOI: 10.1016/j.jcv.2005.08.010</identifier><identifier>PMID: 16384745</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Congenital infection ; Cytomegalovirus ; Cytomegalovirus - genetics ; Cytomegalovirus - isolation & purification ; Cytomegalovirus Infections - complications ; Cytomegalovirus Infections - congenital ; Cytomegalovirus Infections - diagnosis ; DNA, Viral - analysis ; DNA, Viral - blood ; Hearing Loss, Sensorineural - etiology ; Hearing Loss, Sensorineural - virology ; Humans ; Infant ; Infant, Newborn ; Neonatal Screening ; Screening ; Sensorineural hearing loss</subject><ispartof>Journal of clinical virology, 2006-02, Vol.35 (2), p.206-209</ispartof><rights>2005 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-611f4f9c6ce2e28a5ae56a64e68fbbcbbf5d3b77d9375c2e5ad7c8e1ecbece643</citedby><cites>FETCH-LOGICAL-c382t-611f4f9c6ce2e28a5ae56a64e68fbbcbbf5d3b77d9375c2e5ad7c8e1ecbece643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcv.2005.08.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16384745$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barbi, Maria</creatorcontrib><creatorcontrib>Binda, Sandro</creatorcontrib><creatorcontrib>Caroppo, Simona</creatorcontrib><creatorcontrib>Primache, Valeria</creatorcontrib><title>Neonatal screening for congenital cytomegalovirus infection and hearing loss</title><title>Journal of clinical virology</title><addtitle>J Clin Virol</addtitle><description>Congenital cytomegalovirus infection causes 20–30% of congenital sensorineural hearing loss (SNHL) cases. Early identification of CMV attributable cases and their successful treatment are often hampered by the late appearance of the damage in a high proportion of children both symptomatic and asymptomatic at birth.
To discuss the feasibility of a screening program aimed at finding congenitally infected babies followed by their audiological monitoring.
Opinion—review article.
Frequency and severity of hearing loss due to congenital CMV suggest it maybe worthwhile setting up neonatal screening campaigns. Structures where SNHL can be diagnosed and treated exist already in many countries as part of universal neonatal audiological screening schemes. A test based on viral DNA extraction from neonatal dried blood spots on Guthrie cards and its amplification by means of a nested PCR (DBS test) seems to offer the best characteristics for use in screening. Clearly it will be necessary to calculate whether the costs of screening, diagnosis and follow-up, and the financial and emotional burden on the families of infected children, are up to the potential gain.</description><subject>Congenital infection</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus - genetics</subject><subject>Cytomegalovirus - isolation & purification</subject><subject>Cytomegalovirus Infections - complications</subject><subject>Cytomegalovirus Infections - congenital</subject><subject>Cytomegalovirus Infections - diagnosis</subject><subject>DNA, Viral - analysis</subject><subject>DNA, Viral - blood</subject><subject>Hearing Loss, Sensorineural - etiology</subject><subject>Hearing Loss, Sensorineural - virology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Neonatal Screening</subject><subject>Screening</subject><subject>Sensorineural hearing loss</subject><issn>1386-6532</issn><issn>1873-5967</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMo3h_AjXTlrjVpmktxJeINBt3oOqSnp2OGTqJJZ8C3N8MMuNPVySHf_8P5CLlgtGKUyetFtYB1VVMqKqoryugeOWZa8VK0Uu3nN9eylILXR-QkpQWlTPBGHZIjJrluVCOOyewFg7eTHYsEEdE7Py-GEAsIfp63zQd8T2GJczuGtYurVDg_IEwu-ML6vvhAGzehMaR0Rg4GOyY8381T8v5w_3b3VM5eH5_vbmclcF1PpWRsaIYWJGCNtbbCopBWNij10HXQdYPoeadU33IloEZhewUaGUKHgLLhp-Rq2_sZw9cK02SWLgGOo_UYVslIJfOlLf0XZIqqVjcsg2wLQsx3RBzMZ3RLG78No2bj2ixMdm02rg3VJrvOmctd-apbYv-b2MnNwM0WwOxi7TCaBA49YO9iNmj64P6o_wG2EpGO</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Barbi, Maria</creator><creator>Binda, Sandro</creator><creator>Caroppo, Simona</creator><creator>Primache, Valeria</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>Neonatal screening for congenital cytomegalovirus infection and hearing loss</title><author>Barbi, Maria ; Binda, Sandro ; Caroppo, Simona ; Primache, Valeria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-611f4f9c6ce2e28a5ae56a64e68fbbcbbf5d3b77d9375c2e5ad7c8e1ecbece643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Congenital infection</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus - genetics</topic><topic>Cytomegalovirus - isolation & purification</topic><topic>Cytomegalovirus Infections - complications</topic><topic>Cytomegalovirus Infections - congenital</topic><topic>Cytomegalovirus Infections - diagnosis</topic><topic>DNA, Viral - analysis</topic><topic>DNA, Viral - blood</topic><topic>Hearing Loss, Sensorineural - etiology</topic><topic>Hearing Loss, Sensorineural - virology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Neonatal Screening</topic><topic>Screening</topic><topic>Sensorineural hearing loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barbi, Maria</creatorcontrib><creatorcontrib>Binda, Sandro</creatorcontrib><creatorcontrib>Caroppo, Simona</creatorcontrib><creatorcontrib>Primache, Valeria</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barbi, Maria</au><au>Binda, Sandro</au><au>Caroppo, Simona</au><au>Primache, Valeria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal screening for congenital cytomegalovirus infection and hearing loss</atitle><jtitle>Journal of clinical virology</jtitle><addtitle>J Clin Virol</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>35</volume><issue>2</issue><spage>206</spage><epage>209</epage><pages>206-209</pages><issn>1386-6532</issn><eissn>1873-5967</eissn><abstract>Congenital cytomegalovirus infection causes 20–30% of congenital sensorineural hearing loss (SNHL) cases. Early identification of CMV attributable cases and their successful treatment are often hampered by the late appearance of the damage in a high proportion of children both symptomatic and asymptomatic at birth.
To discuss the feasibility of a screening program aimed at finding congenitally infected babies followed by their audiological monitoring.
Opinion—review article.
Frequency and severity of hearing loss due to congenital CMV suggest it maybe worthwhile setting up neonatal screening campaigns. Structures where SNHL can be diagnosed and treated exist already in many countries as part of universal neonatal audiological screening schemes. A test based on viral DNA extraction from neonatal dried blood spots on Guthrie cards and its amplification by means of a nested PCR (DBS test) seems to offer the best characteristics for use in screening. Clearly it will be necessary to calculate whether the costs of screening, diagnosis and follow-up, and the financial and emotional burden on the families of infected children, are up to the potential gain.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>16384745</pmid><doi>10.1016/j.jcv.2005.08.010</doi><tpages>4</tpages></addata></record> |
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subjects | Congenital infection Cytomegalovirus Cytomegalovirus - genetics Cytomegalovirus - isolation & purification Cytomegalovirus Infections - complications Cytomegalovirus Infections - congenital Cytomegalovirus Infections - diagnosis DNA, Viral - analysis DNA, Viral - blood Hearing Loss, Sensorineural - etiology Hearing Loss, Sensorineural - virology Humans Infant Infant, Newborn Neonatal Screening Screening Sensorineural hearing loss |
title | Neonatal screening for congenital cytomegalovirus infection and hearing loss |
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