Near-Field Scanning Optical Microscopy Measurements of Fluorescent Molecular Probes Binding to Insulin Amyloid Fibrils

The binding of two amyloid fibril stain dyes, thioflavin T (ThT) and its neutral analog 2-[4′-(dimethylamino)phenyl]-benzothiazole (BTA-2), are measured using near-field scanning optical microscopy (NSOM), which is able to image individual amyloid fibrils. Polarized NSOM images reveal that both dyes...

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Veröffentlicht in:	The journal of physical chemistry. B 2009-09, Vol.113 (35), p.12090-12095
Hauptverfasser:	Kitts, Catherine C, Bout, David A. Vanden
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - chemistry Aniline Compounds - chemistry Animals B: Biophysical Chemistry Benzothiazoles - chemistry Biophysics - methods Cattle Fluorescent Dyes - chemistry Fluorescent Dyes - pharmacology Hydrogen-Ion Concentration Insulin - chemistry Magnetic Resonance Spectroscopy Micelles Microscopy, Atomic Force - methods Microscopy, Fluorescence - instrumentation Microscopy, Fluorescence - methods Protein Binding Thiazoles - chemistry
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