Xhairy2 functions in Xenopus lens development by regulating p27(xic1) expression

Lens of vertebrate eyes is derived from competent pre-placodal ectoderm in response to signal(s) from retinal lineage. We herein report that the Xenopus Hes gene Xhairy2, which is expressed in pre-placodal ectoderm, is required for lens development from the initial stage. We show that Xhairy2 knockd...

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Veröffentlicht in:	Developmental dynamics 2009-09, Vol.238 (9), p.2179-2192
Hauptverfasser:	Murato, Yasuhito, Hashimoto, Chikara
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - physiology Cyclin-Dependent Kinase Inhibitor p27 - genetics Cyclin-Dependent Kinase Inhibitor p27 - physiology Ectoderm - metabolism Embryo, Nonmammalian - metabolism Gene Expression Regulation, Developmental - genetics Gene Expression Regulation, Developmental - physiology Immunohistochemistry In Situ Hybridization Lens, Crystalline - embryology Lens, Crystalline - metabolism Xenopus laevis - embryology Xenopus laevis - metabolism Xenopus Proteins - genetics Xenopus Proteins - physiology
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