Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis

Clinical and epidemiological studies have found that type 2 diabetes, and hyperinsulinaemia, increased the risk of developing Alzheimer's disease (AD) in the elderly. The link between hyperinsulinaemia and AD may be insulin-degrading enzyme (IDE). This enzyme degrades both insulin and amylin, p...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurobiology of aging 2006-02, Vol.27 (2), p.190-198
Hauptverfasser:	Qiu, Wei Qiao, Folstein, Marshal F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - complications Alzheimer Disease - metabolism Amyloid beta-Peptides - metabolism Amyloid β-peptide Animals Apolipoprotein E4 Apolipoproteins E - metabolism Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Humans Hyperinsulinism - metabolism Insulin Insulin - metabolism Insulin-degrading enzyme Insulysin - genetics Insulysin - metabolism Medical sciences Models, Biological Neurology Risk Type 2 diabetes and Alzheimer's disease
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!