Amygdaloid GABA, not glutamate neurotransmission or mRNA transcription controls footshock-associated fear arousal in the acoustic startle paradigm

In Pavlovian conditioning the fear-evoking properties of the aversive unconditioned stimulus are represented by the conditioned stimulus. A major challenge for theories of classical fear conditioning has been to understand how associations are formed between a conditioned stimulus and unconditioned...

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Veröffentlicht in:	Neuroscience 2006, Vol.137 (2), p.707-716
Hauptverfasser:	Van Nobelen, M., Kokkinidis, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation amygdala Amygdala - drug effects Amygdala - metabolism Animals Arousal - drug effects Arousal - physiology Avoidance Learning - drug effects Avoidance Learning - physiology Biological and medical sciences conditioned fear Dose-Response Relationship, Drug Electric Stimulation Excitatory Amino Acid Antagonists - pharmacology Fear - drug effects Fear - physiology Fundamental and applied biological sciences. Psychology GABA A receptors GABA Agonists - pharmacology gamma-Aminobutyric Acid - metabolism glutamate receptors Glutamic Acid - metabolism Male mRNA transcription Neural Inhibition - drug effects Neural Inhibition - physiology Neural Pathways - drug effects Neural Pathways - metabolism Protein Synthesis Inhibitors - pharmacology Rats Rats, Wistar Receptors, GABA-A - drug effects Receptors, GABA-A - metabolism Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - metabolism Reflex, Startle - drug effects Reflex, Startle - physiology RNA, Messenger - metabolism Synaptic Transmission - drug effects Synaptic Transmission - physiology unconditioned fear Vertebrates: nervous system and sense organs
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