Production of lipid peroxidation products in osteoarthritic tissues: New evidence linking 4‐hydroxynonenal to cartilage degradation

Objective The lipid peroxidation product 4‐hydroxynonenal (HNE) is prominently produced in osteoarthritic (OA) synovial cells, but its specific contribution to cartilage destruction is not understood. This study was designed to test whether HNE signaling and binding are involved in OA cartilage degr...

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Veröffentlicht in:	Arthritis and rheumatism 2006-01, Vol.54 (1), p.271-281
Hauptverfasser:	Morquette, Barbara, Shi, Qin, Lavigne, Patrick, Ranger, Pierre, Fernandes, Julio C., Benderdour, Mohamed
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aldehydes - metabolism Biological and medical sciences Cartilage, Articular - metabolism Collagen Type II - metabolism Collagenases - biosynthesis Diseases of the osteoarticular system Humans Lipid Peroxidation Matrix Metalloproteinase 13 Medical sciences Middle Aged Miscellaneous. Osteoarticular involvement in other diseases Osteoarthritis Osteoarthritis - metabolism
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