Accelerating Effect of Human Leukocyte Antigen-Bw6 Homozygosity on Disease Progression in Chinese HIV-1-Infected Patients
Most HIV-1-infected individuals progress to AIDS within 8 to 10 years after seroconversion. Less than 5% of them, however, remain asymptomatic, although their CD4 T-cell counts stay normal. In this study, our polymerase chain reaction sequence-specified primer (PCR-SSP) based human leukocyte antigen...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2006-02, Vol.41 (2), p.137-139 |
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| container_title | Journal of acquired immune deficiency syndromes (1999) |
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| creator | Qing, Manli Li, Taisheng Han, Yang Qiu, Zhifeng Jiao, Yang |
| description | Most HIV-1-infected individuals progress to AIDS within 8 to 10 years after seroconversion. Less than 5% of them, however, remain asymptomatic, although their CD4 T-cell counts stay normal. In this study, our polymerase chain reaction sequence-specified primer (PCR-SSP) based human leukocyte antigen (HLA)-B genotyping of 28 typical progressors (TPs) and 15 long-term nonprogressors (LTNPs) revealed some evidence that an HLA-B locus polymorphism can influence the rate of disease progression in Chinese HIV-1-infected individuals12 of 28 TPs (43%) were HLA-Bw6 homozygotes. Only 1 of 15 LTNPs (6.7%) was homozygous for the polymorphism (P = 0.013), suggesting that HLA-Bw6 homozygosity is associated with accelerated disease progression. In contrast, 3 of 15 LTNPs (20%) were HLA-Bw4 homozygotes, whereas none of the 28 TPs were homozygotes (P = 0.037), supporting the conclusion that HLA-Bw4 homozygosity may have a protective role. Interestingly, the frequency of the HLA-B*15 allele was extremely high in the TP group (23.2%), which may be associated with faster disease progression in Chinese patients. |
| doi_str_mv | 10.1097/01.qai.0000195607.25262.92 |
| format | Article |
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Less than 5% of them, however, remain asymptomatic, although their CD4 T-cell counts stay normal. In this study, our polymerase chain reaction sequence-specified primer (PCR-SSP) based human leukocyte antigen (HLA)-B genotyping of 28 typical progressors (TPs) and 15 long-term nonprogressors (LTNPs) revealed some evidence that an HLA-B locus polymorphism can influence the rate of disease progression in Chinese HIV-1-infected individuals12 of 28 TPs (43%) were HLA-Bw6 homozygotes. Only 1 of 15 LTNPs (6.7%) was homozygous for the polymorphism (P = 0.013), suggesting that HLA-Bw6 homozygosity is associated with accelerated disease progression. In contrast, 3 of 15 LTNPs (20%) were HLA-Bw4 homozygotes, whereas none of the 28 TPs were homozygotes (P = 0.037), supporting the conclusion that HLA-Bw4 homozygosity may have a protective role. Interestingly, the frequency of the HLA-B*15 allele was extremely high in the TP group (23.2%), which may be associated with faster disease progression in Chinese patients.</description><identifier>ISSN: 1525-4135</identifier><identifier>EISSN: 1944-7884</identifier><identifier>DOI: 10.1097/01.qai.0000195607.25262.92</identifier><identifier>PMID: 16394843</identifier><identifier>CODEN: JDSRET</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; AIDS/HIV ; Biological and medical sciences ; China ; Disease Progression ; Female ; Fundamental and applied biological sciences. Psychology ; HIV ; HIV Infections - diagnosis ; HIV Infections - genetics ; HIV-1 ; HLA-B Antigens - genetics ; Homozygote ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Leukocytes ; Male ; Medical sciences ; Microbiology ; Miscellaneous ; Polymorphism ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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Less than 5% of them, however, remain asymptomatic, although their CD4 T-cell counts stay normal. In this study, our polymerase chain reaction sequence-specified primer (PCR-SSP) based human leukocyte antigen (HLA)-B genotyping of 28 typical progressors (TPs) and 15 long-term nonprogressors (LTNPs) revealed some evidence that an HLA-B locus polymorphism can influence the rate of disease progression in Chinese HIV-1-infected individuals12 of 28 TPs (43%) were HLA-Bw6 homozygotes. Only 1 of 15 LTNPs (6.7%) was homozygous for the polymorphism (P = 0.013), suggesting that HLA-Bw6 homozygosity is associated with accelerated disease progression. In contrast, 3 of 15 LTNPs (20%) were HLA-Bw4 homozygotes, whereas none of the 28 TPs were homozygotes (P = 0.037), supporting the conclusion that HLA-Bw4 homozygosity may have a protective role. Interestingly, the frequency of the HLA-B*15 allele was extremely high in the TP group (23.2%), which may be associated with faster disease progression in Chinese patients.</description><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>China</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - genetics</subject><subject>HIV-1</subject><subject>HLA-B Antigens - genetics</subject><subject>Homozygote</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Leukocytes</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Polymorphism</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Virology</subject><issn>1525-4135</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEUhUcIRB_wF5BVCXYTrh9jj9mloSWRItEFsLWcmTuJ24nd2jOKwq_HIZEiscEbW1ffPcdHpyhuKEwoaPUZ6OTFugnkQ3UlQU1YxSSbaPaquKRaiFLVtXid3xWrSkF5dVFcpfSYcSmEfltcUMm1qAW_LPbTpsEeox2cX5O7rsNmIKEj83FrPVni-BSa_YBk6ge3Rl_e7iSZh234vV-H5IY9CZ58dQltQvIQwzpiSi7PnCezjfOYx_PFr5KWC3-QxpY8ZCv0Q3pXvOlsn_D96b4uft7f_ZjNy-X3b4vZdFk2FTBWalAosAJE2bQrwXUtc8KWdbylq1owakG3WK2kraWwSmVWCS50Z22GKsmvi09H3ecYXkZMg9m6lDP31mMYk5FKgoZa_xekikmq5UHx5h_wMYzR5xCGcS6ZBsEz9OUINTGkFLEzz9FtbdwbCuZQowFqco3mXKP5W6PRLC9_ODmMqy2259VTbxn4eAJsamzfResbl86cEorWAJkTR24X-gFjeurHHUazQdsPm2xNmeRclAxAAgMK5eE3jP8BKfe1Mw</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Qing, Manli</creator><creator>Li, Taisheng</creator><creator>Han, Yang</creator><creator>Qiu, Zhifeng</creator><creator>Jiao, Yang</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7T5</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>Accelerating Effect of Human Leukocyte Antigen-Bw6 Homozygosity on Disease Progression in Chinese HIV-1-Infected Patients</title><author>Qing, Manli ; Li, Taisheng ; Han, Yang ; Qiu, Zhifeng ; Jiao, Yang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5022-907e4e50ee6cdb43986944d2f3d1b8421a09de5b6a864a774e574349faad2f563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>China</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIV</topic><topic>HIV Infections - diagnosis</topic><topic>HIV Infections - genetics</topic><topic>HIV-1</topic><topic>HLA-B Antigens - genetics</topic><topic>Homozygote</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Leukocytes</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Polymorphism</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qing, Manli</creatorcontrib><creatorcontrib>Li, Taisheng</creatorcontrib><creatorcontrib>Han, Yang</creatorcontrib><creatorcontrib>Qiu, Zhifeng</creatorcontrib><creatorcontrib>Jiao, Yang</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qing, Manli</au><au>Li, Taisheng</au><au>Han, Yang</au><au>Qiu, Zhifeng</au><au>Jiao, Yang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accelerating Effect of Human Leukocyte Antigen-Bw6 Homozygosity on Disease Progression in Chinese HIV-1-Infected Patients</atitle><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle><addtitle>J Acquir Immune Defic Syndr</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>41</volume><issue>2</issue><spage>137</spage><epage>139</epage><pages>137-139</pages><issn>1525-4135</issn><eissn>1944-7884</eissn><coden>JDSRET</coden><abstract>Most HIV-1-infected individuals progress to AIDS within 8 to 10 years after seroconversion. 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| ispartof | Journal of acquired immune deficiency syndromes (1999), 2006-02, Vol.41 (2), p.137-139 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Ovid Autoload; Free E- Journals |
| subjects | Adult AIDS/HIV Biological and medical sciences China Disease Progression Female Fundamental and applied biological sciences. Psychology HIV HIV Infections - diagnosis HIV Infections - genetics HIV-1 HLA-B Antigens - genetics Homozygote Human immunodeficiency virus Human viral diseases Humans Infectious diseases Leukocytes Male Medical sciences Microbiology Miscellaneous Polymorphism Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology |
| title | Accelerating Effect of Human Leukocyte Antigen-Bw6 Homozygosity on Disease Progression in Chinese HIV-1-Infected Patients |
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