Type I Collagen Limits VEGFR-2 Signaling by a SHP2 Protein-Tyrosine Phosphatase–Dependent Mechanism 1

During angiogenesis, a combined action between newly secreted extracellular matrix proteins and the repertoire of integrins expressed by endothelial cells contributes in the regulation of their biological functions. Extracellular matrix-engaged integrins influence tyrosine kinase receptors, thus pro...

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Veröffentlicht in:	Circulation research 2006-01, Vol.98 (1), p.45-54
Hauptverfasser:	Mitola, Stefania, Brenchio, Barbara, Piccinini, Marco, Tertoolen, Leon, Zammataro, Luca, Breier, Georg, Rinaudo, Maria Teresa, den Hertog, Jeroen, Arese, Marco, Bussolino, Federico
Format:	Artikel
Sprache:	eng
Schlagworte:	Collagen Type I - pharmacology Endothelial Cells - physiology Humans Intracellular Signaling Peptides and Proteins - physiology Neovascularization, Physiologic Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 11 Protein Tyrosine Phosphatases - physiology Signal Transduction Tyrosine - metabolism Vascular Endothelial Growth Factor A - pharmacology Vascular Endothelial Growth Factor Receptor-2 - metabolism Vitronectin - pharmacology
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