Theophylline attenuates hippocampal blood flow responses induced by tooth pulp stimulation in rats

In this study, we performed tests to determine whether tooth pulp stimulation (TPS) increases hippocampal blood flow (HBF), and if so, to investigate whether the increase in HBF is mediated via the activation of adenosine receptors. We measured HBF in urethane-anesthetized rats using laser Doppler f...

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Veröffentlicht in:	Neuroscience research 2009-10, Vol.65 (2), p.156-159
Hauptverfasser:	Hasegawa, Makoto, Hada, Junichi, Abe, Tetsuya, Honda, Kousuke, Shimizu, Akihiko, Urade, Masahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine - metabolism Afferent Pathways - drug effects Afferent Pathways - physiology Animals Cerebral Arteries - metabolism Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Dental Pulp Cavity - innervation Dental Pulp Cavity - physiopathology Disease Models, Animal Electric Stimulation - adverse effects Hippocampal blood flow Hippocampus - blood supply Hippocampus - drug effects Hippocampus - metabolism Injections, Intraperitoneal Laser-Doppler Flowmetry Male Nociceptors - drug effects Nociceptors - physiology Purinergic P1 Receptor Antagonists Rats Rats, Wistar Receptors, Purinergic P1 - metabolism Theophylline Theophylline - pharmacology Tooth pulp stimulation Toothache - metabolism Toothache - physiopathology Vasodilator Agents - pharmacology
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