Theophylline attenuates hippocampal blood flow responses induced by tooth pulp stimulation in rats
In this study, we performed tests to determine whether tooth pulp stimulation (TPS) increases hippocampal blood flow (HBF), and if so, to investigate whether the increase in HBF is mediated via the activation of adenosine receptors. We measured HBF in urethane-anesthetized rats using laser Doppler f...
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| Veröffentlicht in: | Neuroscience research 2009-10, Vol.65 (2), p.156-159 |
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| creator | Hasegawa, Makoto Hada, Junichi Abe, Tetsuya Honda, Kousuke Shimizu, Akihiko Urade, Masahiro |
| description | In this study, we performed tests to determine whether tooth pulp stimulation (TPS) increases hippocampal blood flow (HBF), and if so, to investigate whether the increase in HBF is mediated via the activation of adenosine receptors. We measured HBF in urethane-anesthetized rats using laser Doppler flowmetry (LDF) and examined the effect of theophylline, a nonselective adenosine receptor antagonist, on TPS-induced HBF responses. TPS increased HBF, and its response was significantly attenuated by the intraperitoneal administration of theophylline (20
mg/kg). These results suggest that the HBF response induced by TPS may be, at least in part, produced through adenosine receptors. |
| doi_str_mv | 10.1016/j.neures.2009.06.009 |
| format | Article |
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mg/kg). These results suggest that the HBF response induced by TPS may be, at least in part, produced through adenosine receptors.</description><subject>Adenosine</subject><subject>Adenosine - metabolism</subject><subject>Afferent Pathways - drug effects</subject><subject>Afferent Pathways - physiology</subject><subject>Animals</subject><subject>Cerebral Arteries - metabolism</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Dental Pulp Cavity - innervation</subject><subject>Dental Pulp Cavity - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Electric Stimulation - adverse effects</subject><subject>Hippocampal blood flow</subject><subject>Hippocampus - blood supply</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Injections, Intraperitoneal</subject><subject>Laser-Doppler Flowmetry</subject><subject>Male</subject><subject>Nociceptors - drug effects</subject><subject>Nociceptors - physiology</subject><subject>Purinergic P1 Receptor Antagonists</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Purinergic P1 - metabolism</subject><subject>Theophylline</subject><subject>Theophylline - pharmacology</subject><subject>Tooth pulp stimulation</subject><subject>Toothache - metabolism</subject><subject>Toothache - physiopathology</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0168-0102</issn><issn>1872-8111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFr3DAQhUVpaTZp_0EpOvVmRyPbsnwplJA2gUAu6VlI1pjVIluuJLfsv6-WXeitucyD4Xsz8B4hn4DVwEDcHuoFt4ip5owNNRN1kTdkB7LnlQSAt2RXMFkxYPyKXKd0YIw1Q9u8J1cwdN3AOrkj5mWPYd0fvXcLUp0zLpvOmOjerWsY9bxqT40PwdLJhz-0PFzDkgrgFruNaKk50hxC3tN18ytN2c2b19mFpRA06pw-kHeT9gk_XvSG_Px-_3L3UD09_3i8-_ZUja2EXLXQG6vBsg4ZSI1tL42QzHactzCZAbgEIcrEzsjTEifWDb2eOJrGStvckC_nu2sMvzZMWc0ujei9XjBsSYleMMkb_irIARoYQBSwPYNjDClFnNQa3azjUQFTpxLUQZ1LUKcSFBOqSLF9vtzfzIz2n-mSegG-ngEscfx2GFUaHS4lTRdxzMoG9_8PfwEFjpu6</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Hasegawa, Makoto</creator><creator>Hada, Junichi</creator><creator>Abe, Tetsuya</creator><creator>Honda, Kousuke</creator><creator>Shimizu, Akihiko</creator><creator>Urade, Masahiro</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20091001</creationdate><title>Theophylline attenuates hippocampal blood flow responses induced by tooth pulp stimulation in rats</title><author>Hasegawa, Makoto ; Hada, Junichi ; Abe, Tetsuya ; Honda, Kousuke ; Shimizu, Akihiko ; Urade, Masahiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-417bda1d05e018ae478b680d52241fb9128166128e5b85224ef0597af2eb3d8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adenosine</topic><topic>Adenosine - metabolism</topic><topic>Afferent Pathways - drug effects</topic><topic>Afferent Pathways - physiology</topic><topic>Animals</topic><topic>Cerebral Arteries - metabolism</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Dental Pulp Cavity - innervation</topic><topic>Dental Pulp Cavity - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Electric Stimulation - adverse effects</topic><topic>Hippocampal blood flow</topic><topic>Hippocampus - blood supply</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Injections, Intraperitoneal</topic><topic>Laser-Doppler Flowmetry</topic><topic>Male</topic><topic>Nociceptors - drug effects</topic><topic>Nociceptors - physiology</topic><topic>Purinergic P1 Receptor Antagonists</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Purinergic P1 - metabolism</topic><topic>Theophylline</topic><topic>Theophylline - pharmacology</topic><topic>Tooth pulp stimulation</topic><topic>Toothache - metabolism</topic><topic>Toothache - physiopathology</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasegawa, Makoto</creatorcontrib><creatorcontrib>Hada, Junichi</creatorcontrib><creatorcontrib>Abe, Tetsuya</creatorcontrib><creatorcontrib>Honda, Kousuke</creatorcontrib><creatorcontrib>Shimizu, Akihiko</creatorcontrib><creatorcontrib>Urade, Masahiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasegawa, Makoto</au><au>Hada, Junichi</au><au>Abe, Tetsuya</au><au>Honda, Kousuke</au><au>Shimizu, Akihiko</au><au>Urade, Masahiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Theophylline attenuates hippocampal blood flow responses induced by tooth pulp stimulation in rats</atitle><jtitle>Neuroscience research</jtitle><addtitle>Neurosci Res</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>65</volume><issue>2</issue><spage>156</spage><epage>159</epage><pages>156-159</pages><issn>0168-0102</issn><eissn>1872-8111</eissn><abstract>In this study, we performed tests to determine whether tooth pulp stimulation (TPS) increases hippocampal blood flow (HBF), and if so, to investigate whether the increase in HBF is mediated via the activation of adenosine receptors. We measured HBF in urethane-anesthetized rats using laser Doppler flowmetry (LDF) and examined the effect of theophylline, a nonselective adenosine receptor antagonist, on TPS-induced HBF responses. TPS increased HBF, and its response was significantly attenuated by the intraperitoneal administration of theophylline (20
mg/kg). These results suggest that the HBF response induced by TPS may be, at least in part, produced through adenosine receptors.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>19559058</pmid><doi>10.1016/j.neures.2009.06.009</doi><tpages>4</tpages></addata></record> |
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| subjects | Adenosine Adenosine - metabolism Afferent Pathways - drug effects Afferent Pathways - physiology Animals Cerebral Arteries - metabolism Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Dental Pulp Cavity - innervation Dental Pulp Cavity - physiopathology Disease Models, Animal Electric Stimulation - adverse effects Hippocampal blood flow Hippocampus - blood supply Hippocampus - drug effects Hippocampus - metabolism Injections, Intraperitoneal Laser-Doppler Flowmetry Male Nociceptors - drug effects Nociceptors - physiology Purinergic P1 Receptor Antagonists Rats Rats, Wistar Receptors, Purinergic P1 - metabolism Theophylline Theophylline - pharmacology Tooth pulp stimulation Toothache - metabolism Toothache - physiopathology Vasodilator Agents - pharmacology |
| title | Theophylline attenuates hippocampal blood flow responses induced by tooth pulp stimulation in rats |
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