PDGF stimulation of Müller cell proliferation: Contributions of c-JNK and the PI3K/Akt pathway

Platelet-derived growth factor (PDGF) has a critical role in proliferative vitreoretinopathy (PVR) as a chemoattractant and mitogen for retinal pigment epithelial cells and retinal glial cells. Here, we investigated the potential effects of PDGF on the proliferation of Müller cells and the intracell...

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Veröffentlicht in:	Biochemical and biophysical research communications 2009-10, Vol.388 (1), p.167-171
Hauptverfasser:	Moon, Sang Woong, Chung, Eun Jee, Jung, Sun-Ah, Lee, Joon H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthracenes - pharmacology Cell Proliferation Chromones - pharmacology Enzyme Inhibitors - pharmacology JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - physiology Morpholines - pharmacology Müller cell Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - physiology Platelet-derived growth factor Platelet-Derived Growth Factor - pharmacology Platelet-Derived Growth Factor - physiology Proliferative vitreoretinopathy Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - physiology Rats Rats, Inbred BN Receptors, Platelet-Derived Growth Factor - agonists Receptors, Platelet-Derived Growth Factor - metabolism Retina - metabolism Retina - pathology Vitreoretinopathy, Proliferative - metabolism Vitreoretinopathy, Proliferative - pathology
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