Activation of Stat3 in Primary Tumors from High-Risk Breast Cancer Patients Is Associated with Elevated Levels of Activated Src and Survivin Expression

Purpose: Constitutive activation of signal transducer and activator of transcription 3 (Stat3) protein has been observed in a wide variety of tumors, including breast cancer, and contributes to oncogenesis at least in part by prevention of apoptosis. In a study of 45 patients with high-risk breast c...

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Veröffentlicht in:	Clinical cancer research 2006-01, Vol.12 (1), p.20-28
Hauptverfasser:	DIAZ, Nills, MINTON, Susan, CANTOR, Alan, LEE, Ji-Hyun, BEAM, Craig A, SULLIVAN, Daniel, JOVE, Richard, MURO-CACHO, Carlos A, COX, Charles, BOWMAN, Tammy, GRITSKO, Tanya, GARCIA, Roy, EWEIS, Ibrahim, WLOCH, Marek, LIVINGSTON, Sandy, SEIJO, Ed
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - therapeutic use Apoptosis - physiology bcl-X Protein - biosynthesis Biological and medical sciences Biomarkers, Tumor - analysis Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Clinical Trials, Phase II as Topic Doxorubicin - therapeutic use Electrophoretic Mobility Shift Assay Enzyme Activation - physiology Female Gynecology. Andrology. Obstetrics Humans Image Processing, Computer-Assisted Immunohistochemistry In Situ Nick-End Labeling Inhibitor of Apoptosis Proteins Ki-67 Antigen - biosynthesis Mammary gland diseases Medical sciences Microtubule-Associated Proteins - biosynthesis molecular biomarkers neoadjuvant chemotherapy Neoadjuvant Therapy Neoplasm Proteins - biosynthesis Pharmacology. Drug treatments Proto-Oncogene Proteins c-bcl-2 - biosynthesis Receptor, Epidermal Growth Factor - biosynthesis Receptor, ErbB-2 - biosynthesis Receptors, Estrogen - biosynthesis Risk Factors Signal transduction src-Family Kinases - biosynthesis STAT3 Transcription Factor - metabolism Taxoids - therapeutic use Tumors
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