TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes

Using an expression cloning strategy, we have identified TFE3, a basic helix-loop-helix protein, as a transactivator of metabolic genes that are regulated through an E-box in their promoters. Adenovirus-mediated expression of TFE3 in hepatocytes in culture and in vivo strongly activated expression o...

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Veröffentlicht in:	Nature medicine 2006-01, Vol.12 (1), p.107-113
Hauptverfasser:	Shimano, Hitoshi, Nakagawa, Yoshimi, Yoshikawa, Tomohiro, Ide, Tomohiro, Tamura, Mariko, Furusawa, Mika, Yamamoto, Takashi, Inoue, Noriyuki, Matsuzaka, Takashi, Takahashi, Akimitsu, Hasty, Alyssa H, Suzuki, Hiroaki, Sone, Hirohito, Toyoshima, Hideo, Yahagi, Naoya, Yamada, Nobuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - metabolism Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - physiology Biomedical and Life Sciences Biomedicine Blood Glucose - metabolism Blotting, Northern Body fat Boxes Cancer Research Carbohydrates Cells, Cultured Chromatin Immunoprecipitation Cloning Cloning, Molecular Diabetes Diabetes Mellitus - therapy Diabetes Mellitus, Experimental Dose-Response Relationship, Drug Drug dosages Genes Glucose Glycogen - metabolism Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Green Fluorescent Proteins - metabolism Hepatocytes - metabolism Hexokinase - metabolism Humans Immunoblotting Immunoprecipitation Infectious Diseases Insulin Insulin - metabolism Insulin Receptor Substrate Proteins Insulin resistance Intracellular Signaling Peptides and Proteins Kinases Lipids Male Membrane Proteins - metabolism Metabolic Diseases Metabolism Mice Mice, Inbred C57BL Mice, Knockout Models, Biological Molecular Medicine Neurosciences Phosphoproteins - metabolism Phosphorylation Plasmids - metabolism Promoter Regions, Genetic Protein Structure, Tertiary Protein synthesis Proteins Proto-Oncogene Proteins c-akt - metabolism Rats Ribosomal Protein S6 Kinases, 70-kDa - metabolism Signal Transduction Sterols Streptozocin - pharmacology Time Factors Transcription factors Transcriptional Activation
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