Detection of EGFR Gene Mutation in Lung Cancer by Mutant-Enriched Polymerase Chain Reaction Assay

Purpose: Mutations in the epidermal growth factor receptor ( EGFR ) gene have been reported to be present in non–small cell lung cancer (NSCLC) and related to the responsiveness of tumors to EGFR tyrosine kinase inhibitors, suggesting its usefulness as a biomarker. Because clinical samples contain t...

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Veröffentlicht in:	Clinical cancer research 2006-01, Vol.12 (1), p.43-48
Hauptverfasser:	ASANO, Hiroaki, TOYOOKA, Shinichi, HIRAKI, Akio, SUGI, Kazuro, KIURA, Katsuyuki, DATE, Hiroshi, SHIMIZU, Nobuyoshi, TOKUMO, Masaki, ICHIMURA, Kouichi, AOE, Keisuke, ITO, Sachio, TSUKUDA, Kazunori, OUCHIDA, Mamoru, AOE, Motoi, KATAYAMA, Hideki
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Biopsy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology CT-guided needle lung biopsy DNA Mutational Analysis DNA Primers EGFR Female Genes, erbB-1 - genetics Humans Lung Neoplasms - genetics Lung Neoplasms - pathology Medical sciences mutant-enriched PCR Mutation NSCLC Pharmacology. Drug treatments Pleural Effusion pleural fluid Pneumology Polymerase Chain Reaction - methods Sensitivity and Specificity Tumors of the respiratory system and mediastinum
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