Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase

A significant impediment to the success of cancer chemotherapy is multidrug resistance (MDR). A typical form of MDR is attributable to the overexpression of membrane transport proteins, such as P-glycoprotein, resulting in an increased drug efflux. In this study, we show that adenovirus-mediated enh...

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Veröffentlicht in:Cancer research (Chicago, Ill.) Ill.), 2006, Vol.66 (1), p.445-452
Hauptverfasser: JUN ZHOU, MIN LIU, ANEJA, Ritu, CHANDRA, Ramesh, LAGE, Hermann, JOSHI, Harish C
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Sprache:eng
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