Biological determinants of endocrine resistance in breast cancer

Key Points Endocrine therapies that target oestrogen action (anti-oestrogens and aromatase inhibitors) are widely used and successful breast cancer therapies, but many women treated with these therapies will relapse with endocrine-resistant disease. Mechanisms of endocrine resistance in oestrogen re...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature reviews. Cancer 2009-09, Vol.9 (9), p.631-643
Hauptverfasser:	Musgrove, Elizabeth A., Sutherland, Robert L.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Antiestrogens Apoptosis Aromatase Biomedicine Breast cancer Breast Neoplasms - drug therapy Cancer Research Cell cycle Cell death Disease resistance Drug resistance Drug Resistance, Neoplasm Drug therapy E2F protein Endocrine therapy Estrogen receptors Extracellular signal-regulated kinase Female Gene expression Genetic aspects Genetic screening Health aspects Hormone Antagonists - therapeutic use Humans Isoforms Kinases Metastases Myc protein Neoplasms, Hormone-Dependent - drug therapy Post-translation Protein-tyrosine kinase receptors review-article Signal transduction Signal Transduction - drug effects Tamoxifen Therapeutic targets Transcription factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!