Synthesis and Biological Evaluation of 6-(Alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one Base and Nucleoside Derivatives

Derivatives of the 2‘-deoxynucleoside of furo[2,3-d]pyrimidin-2(3H)-one with long-chain alkyl (or 4-alkylphenyl) substituents at C6 exhibit remarkable anti-VZV (varicella-zoster virus) potency and selectivity, and analogous 2‘,3‘-dideoxynucleoside derivatives show anti-HCMV (human cytomegalovirus) a...

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Veröffentlicht in:	Journal of medicinal chemistry 2006-01, Vol.49 (1), p.391-398
Hauptverfasser:	Robins, Morris J, Miranda, Karl, Rajwanshi, Vivek K, Peterson, Matt A, Andrei, Graciela, Snoeck, Robert, De Clercq, Erik, Balzarini, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Cell Line Cell Proliferation - drug effects Cytomegalovirus - drug effects Herpesvirus 3, Human - drug effects Humans Medical sciences Microbial Sensitivity Tests Molecular Structure Pharmacology. Drug treatments Pyrimidine Nucleosides - chemical synthesis Pyrimidine Nucleosides - chemistry Pyrimidine Nucleosides - pharmacology Stereoisomerism Structure-Activity Relationship
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