p16 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study
Distinguishing between keratoacanthoma (KA) and squamous cell carcinoma (SCC) is not an uncommon histologic diagnostic dilemma. To determine if p16 expression is useful in the differential diagnosis of SCC and KA. We studied the expression of p16 by immunohistochemistry in 24 KAs, 24 infiltrating SC...
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Veröffentlicht in: | Archives of pathology & laboratory medicine (1976) 2006-01, Vol.130 (1), p.69-73 |
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creator | Kaabipour, Emad Haupt, Helen M Stern, Jere B Kanetsky, Peter A Podolski, Victoria F Martin, Anne-Marie |
description | Distinguishing between keratoacanthoma (KA) and squamous cell carcinoma (SCC) is not an uncommon histologic diagnostic dilemma.
To determine if p16 expression is useful in the differential diagnosis of SCC and KA.
We studied the expression of p16 by immunohistochemistry in 24 KAs, 24 infiltrating SCCs of the skin, 4 histologically indeterminate lesions, and 8 nonmalignant keratoses.
A range of immunohistochemical p16 expression was seen in KAs and SCCs in terms of the thickness of lesional staining and the percentage of cells staining. No significant difference in measures of p16 expression was identified among the KAs, the SCCs, the indeterminate lesions, or the benign keratoses.
These findings suggest that p16 is not a useful marker to distinguish between KA and SCC, supporting the similarity between the 2 lesions; p16 alterations appear to play a role in the pathogenesis of both KA and SCC. |
doi_str_mv | 10.5858/2006-130-69-PEIKAS |
format | Article |
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To determine if p16 expression is useful in the differential diagnosis of SCC and KA.
We studied the expression of p16 by immunohistochemistry in 24 KAs, 24 infiltrating SCCs of the skin, 4 histologically indeterminate lesions, and 8 nonmalignant keratoses.
A range of immunohistochemical p16 expression was seen in KAs and SCCs in terms of the thickness of lesional staining and the percentage of cells staining. No significant difference in measures of p16 expression was identified among the KAs, the SCCs, the indeterminate lesions, or the benign keratoses.
These findings suggest that p16 is not a useful marker to distinguish between KA and SCC, supporting the similarity between the 2 lesions; p16 alterations appear to play a role in the pathogenesis of both KA and SCC.</description><identifier>ISSN: 0003-9985</identifier><identifier>EISSN: 1543-2165</identifier><identifier>DOI: 10.5858/2006-130-69-PEIKAS</identifier><identifier>PMID: 16390241</identifier><identifier>CODEN: APLMAS</identifier><language>eng</language><publisher>United States: College of American Pathologists</publisher><subject>Age ; Aged ; Aged, 80 and over ; Antigens ; Biomarkers, Tumor - metabolism ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Cell Count ; Cell cycle ; Cell division ; Cyclin-Dependent Kinase Inhibitor p16 - metabolism ; Diagnosis, Differential ; Female ; Humans ; Immunoenzyme Techniques ; Keratoacanthoma - diagnosis ; Keratoacanthoma - metabolism ; Keratoacanthoma - pathology ; Keratosis - metabolism ; Keratosis - pathology ; Kinases ; Male ; Middle Aged ; Proteins ; Retinoblastoma ; Skin Neoplasms - diagnosis ; Skin Neoplasms - metabolism ; Skin Neoplasms - pathology ; Tumors</subject><ispartof>Archives of pathology & laboratory medicine (1976), 2006-01, Vol.130 (1), p.69-73</ispartof><rights>Copyright College of American Pathologists Jan 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c243t-a9400590fc15af07a412f4252998988f9bf6bda5fa5b288e916817d6730bd4083</citedby><cites>FETCH-LOGICAL-c243t-a9400590fc15af07a412f4252998988f9bf6bda5fa5b288e916817d6730bd4083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16390241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaabipour, Emad</creatorcontrib><creatorcontrib>Haupt, Helen M</creatorcontrib><creatorcontrib>Stern, Jere B</creatorcontrib><creatorcontrib>Kanetsky, Peter A</creatorcontrib><creatorcontrib>Podolski, Victoria F</creatorcontrib><creatorcontrib>Martin, Anne-Marie</creatorcontrib><title>p16 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study</title><title>Archives of pathology & laboratory medicine (1976)</title><addtitle>Arch Pathol Lab Med</addtitle><description>Distinguishing between keratoacanthoma (KA) and squamous cell carcinoma (SCC) is not an uncommon histologic diagnostic dilemma.
To determine if p16 expression is useful in the differential diagnosis of SCC and KA.
We studied the expression of p16 by immunohistochemistry in 24 KAs, 24 infiltrating SCCs of the skin, 4 histologically indeterminate lesions, and 8 nonmalignant keratoses.
A range of immunohistochemical p16 expression was seen in KAs and SCCs in terms of the thickness of lesional staining and the percentage of cells staining. No significant difference in measures of p16 expression was identified among the KAs, the SCCs, the indeterminate lesions, or the benign keratoses.
These findings suggest that p16 is not a useful marker to distinguish between KA and SCC, supporting the similarity between the 2 lesions; p16 alterations appear to play a role in the pathogenesis of both KA and SCC.</description><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Count</subject><subject>Cell cycle</subject><subject>Cell division</subject><subject>Cyclin-Dependent Kinase Inhibitor p16 - metabolism</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Keratoacanthoma - diagnosis</subject><subject>Keratoacanthoma - metabolism</subject><subject>Keratoacanthoma - pathology</subject><subject>Keratosis - metabolism</subject><subject>Keratosis - pathology</subject><subject>Kinases</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Proteins</subject><subject>Retinoblastoma</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - pathology</subject><subject>Tumors</subject><issn>0003-9985</issn><issn>1543-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdUV1LXDEUDMVSt1v_gA8SfOjbbU8-N-mbiLZSQcH6HHJzEza6N1mTe6H-e7PuQqFPh8OZGWbOIHRK4JtQQn2nALIjDDqpu_urm98XDx_QggjOOkqkOEILAGCd1koco8-1PrVVU0o-oWMimQbKyQLFLZHY_90WX2vMCceEn32xU7bOpmmdR1uxTQOuL7Md81yx85sNdra4mN6POeBp7XF9julHQ-I4jnPK61in7NZ-jM5ucJ3m4fUL-hjspvqTw1yix-urP5e_utu7nzeXF7edo5xNndUcQGgIjggbYGU5oYFTQVsOrVTQfZD9YEWwoqdKeU2kIqtBrhj0AwfFlujrXndb8svs62TGWHeubfItgJErCYIDacDz_4BPeS6peTOUEM0kb6JLRPcgV3KtxQezLXG05dUQMLsWzK4F01owUpt9C410dlCe-9EP_yiHt7M3KqKDZg</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Kaabipour, Emad</creator><creator>Haupt, Helen M</creator><creator>Stern, Jere B</creator><creator>Kanetsky, Peter A</creator><creator>Podolski, Victoria F</creator><creator>Martin, Anne-Marie</creator><general>College of American Pathologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>200601</creationdate><title>p16 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study</title><author>Kaabipour, Emad ; Haupt, Helen M ; Stern, Jere B ; Kanetsky, Peter A ; Podolski, Victoria F ; Martin, Anne-Marie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c243t-a9400590fc15af07a412f4252998988f9bf6bda5fa5b288e916817d6730bd4083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Count</topic><topic>Cell cycle</topic><topic>Cell division</topic><topic>Cyclin-Dependent Kinase Inhibitor p16 - metabolism</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Keratoacanthoma - diagnosis</topic><topic>Keratoacanthoma - metabolism</topic><topic>Keratoacanthoma - pathology</topic><topic>Keratosis - metabolism</topic><topic>Keratosis - pathology</topic><topic>Kinases</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Proteins</topic><topic>Retinoblastoma</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - metabolism</topic><topic>Skin Neoplasms - pathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaabipour, Emad</creatorcontrib><creatorcontrib>Haupt, Helen M</creatorcontrib><creatorcontrib>Stern, Jere B</creatorcontrib><creatorcontrib>Kanetsky, Peter A</creatorcontrib><creatorcontrib>Podolski, Victoria F</creatorcontrib><creatorcontrib>Martin, Anne-Marie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of pathology & laboratory medicine (1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaabipour, Emad</au><au>Haupt, Helen M</au><au>Stern, Jere B</au><au>Kanetsky, Peter A</au><au>Podolski, Victoria F</au><au>Martin, Anne-Marie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>p16 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study</atitle><jtitle>Archives of pathology & laboratory medicine (1976)</jtitle><addtitle>Arch Pathol Lab Med</addtitle><date>2006-01</date><risdate>2006</risdate><volume>130</volume><issue>1</issue><spage>69</spage><epage>73</epage><pages>69-73</pages><issn>0003-9985</issn><eissn>1543-2165</eissn><coden>APLMAS</coden><abstract>Distinguishing between keratoacanthoma (KA) and squamous cell carcinoma (SCC) is not an uncommon histologic diagnostic dilemma.
To determine if p16 expression is useful in the differential diagnosis of SCC and KA.
We studied the expression of p16 by immunohistochemistry in 24 KAs, 24 infiltrating SCCs of the skin, 4 histologically indeterminate lesions, and 8 nonmalignant keratoses.
A range of immunohistochemical p16 expression was seen in KAs and SCCs in terms of the thickness of lesional staining and the percentage of cells staining. No significant difference in measures of p16 expression was identified among the KAs, the SCCs, the indeterminate lesions, or the benign keratoses.
These findings suggest that p16 is not a useful marker to distinguish between KA and SCC, supporting the similarity between the 2 lesions; p16 alterations appear to play a role in the pathogenesis of both KA and SCC.</abstract><cop>United States</cop><pub>College of American Pathologists</pub><pmid>16390241</pmid><doi>10.5858/2006-130-69-PEIKAS</doi><tpages>5</tpages></addata></record> |
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source | MEDLINE; Allen Press Journals; EZB-FREE-00999 freely available EZB journals |
subjects | Age Aged Aged, 80 and over Antigens Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Count Cell cycle Cell division Cyclin-Dependent Kinase Inhibitor p16 - metabolism Diagnosis, Differential Female Humans Immunoenzyme Techniques Keratoacanthoma - diagnosis Keratoacanthoma - metabolism Keratoacanthoma - pathology Keratosis - metabolism Keratosis - pathology Kinases Male Middle Aged Proteins Retinoblastoma Skin Neoplasms - diagnosis Skin Neoplasms - metabolism Skin Neoplasms - pathology Tumors |
title | p16 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study |
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