p16 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study

Distinguishing between keratoacanthoma (KA) and squamous cell carcinoma (SCC) is not an uncommon histologic diagnostic dilemma. To determine if p16 expression is useful in the differential diagnosis of SCC and KA. We studied the expression of p16 by immunohistochemistry in 24 KAs, 24 infiltrating SC...

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Veröffentlicht in:Archives of pathology & laboratory medicine (1976) 2006-01, Vol.130 (1), p.69-73
Hauptverfasser: Kaabipour, Emad, Haupt, Helen M, Stern, Jere B, Kanetsky, Peter A, Podolski, Victoria F, Martin, Anne-Marie
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container_issue 1
container_start_page 69
container_title Archives of pathology & laboratory medicine (1976)
container_volume 130
creator Kaabipour, Emad
Haupt, Helen M
Stern, Jere B
Kanetsky, Peter A
Podolski, Victoria F
Martin, Anne-Marie
description Distinguishing between keratoacanthoma (KA) and squamous cell carcinoma (SCC) is not an uncommon histologic diagnostic dilemma. To determine if p16 expression is useful in the differential diagnosis of SCC and KA. We studied the expression of p16 by immunohistochemistry in 24 KAs, 24 infiltrating SCCs of the skin, 4 histologically indeterminate lesions, and 8 nonmalignant keratoses. A range of immunohistochemical p16 expression was seen in KAs and SCCs in terms of the thickness of lesional staining and the percentage of cells staining. No significant difference in measures of p16 expression was identified among the KAs, the SCCs, the indeterminate lesions, or the benign keratoses. These findings suggest that p16 is not a useful marker to distinguish between KA and SCC, supporting the similarity between the 2 lesions; p16 alterations appear to play a role in the pathogenesis of both KA and SCC.
doi_str_mv 10.5858/2006-130-69-PEIKAS
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source MEDLINE; Allen Press Journals; EZB-FREE-00999 freely available EZB journals
subjects Age
Aged
Aged, 80 and over
Antigens
Biomarkers, Tumor - metabolism
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cell Count
Cell cycle
Cell division
Cyclin-Dependent Kinase Inhibitor p16 - metabolism
Diagnosis, Differential
Female
Humans
Immunoenzyme Techniques
Keratoacanthoma - diagnosis
Keratoacanthoma - metabolism
Keratoacanthoma - pathology
Keratosis - metabolism
Keratosis - pathology
Kinases
Male
Middle Aged
Proteins
Retinoblastoma
Skin Neoplasms - diagnosis
Skin Neoplasms - metabolism
Skin Neoplasms - pathology
Tumors
title p16 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study
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