Risk of schizophrenia in people with coeliac disease, ulcerative colitis and Crohn's disease: a general population‐based study
Summary Background Recently, interest has been revived in whether people with coeliac disease, in contrast to other inflammatory gastrointestinal diseases, have an increased risk of schizophrenia. Aim To compare the risk of schizophrenia in people diagnosed with coeliac disease, ulcerative colitis a...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2006-01, Vol.23 (1), p.71-74 |
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| creator | WEST, J. LOGAN, R. F. HUBBARD, R. B. CARD, T. R. |
| description | Summary
Background
Recently, interest has been revived in whether people with coeliac disease, in contrast to other inflammatory gastrointestinal diseases, have an increased risk of schizophrenia.
Aim
To compare the risk of schizophrenia in people diagnosed with coeliac disease, ulcerative colitis and Crohn's disease with the general population.
Methods
We used data from the UK General Practice Research Database. People with coeliac disease, Crohn's disease and ulcerative colitis were matched individually with five age‐, sex‐ and general practice‐matched controls. The prevalence of schizophrenia was calculated and compared between disease groups and their respective controls. We calculated odds ratios for schizophrenia using conditional logistic regression adjusting for smoking status.
Results
In people with coeliac disease, Crohn's disease and ulcerative colitis the prevalence of schizophrenia was 0.25%, 0.27% and 0.24%, respectively, compared with a general population prevalence of 0.37%. The adjusted odds ratios showed no association between schizophrenia and gastrointestinal disease (coeliac disease vs. controls 0.76, 95% CI: 0.41–1.4; Crohn's disease vs. controls 0.74, 95% CI: 0.44–1.3; ulcerative colitis 0.71, 95% CI: 0.44–1.1).
Conclusions Contrary to recent findings we found no evidence of an increased risk of schizophrenia in people with coeliac disease compared with the general population. |
| doi_str_mv | 10.1111/j.1365-2036.2006.02720.x |
| format | Article |
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Background
Recently, interest has been revived in whether people with coeliac disease, in contrast to other inflammatory gastrointestinal diseases, have an increased risk of schizophrenia.
Aim
To compare the risk of schizophrenia in people diagnosed with coeliac disease, ulcerative colitis and Crohn's disease with the general population.
Methods
We used data from the UK General Practice Research Database. People with coeliac disease, Crohn's disease and ulcerative colitis were matched individually with five age‐, sex‐ and general practice‐matched controls. The prevalence of schizophrenia was calculated and compared between disease groups and their respective controls. We calculated odds ratios for schizophrenia using conditional logistic regression adjusting for smoking status.
Results
In people with coeliac disease, Crohn's disease and ulcerative colitis the prevalence of schizophrenia was 0.25%, 0.27% and 0.24%, respectively, compared with a general population prevalence of 0.37%. The adjusted odds ratios showed no association between schizophrenia and gastrointestinal disease (coeliac disease vs. controls 0.76, 95% CI: 0.41–1.4; Crohn's disease vs. controls 0.74, 95% CI: 0.44–1.3; ulcerative colitis 0.71, 95% CI: 0.44–1.1).
Conclusions Contrary to recent findings we found no evidence of an increased risk of schizophrenia in people with coeliac disease compared with the general population.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/j.1365-2036.2006.02720.x</identifier><identifier>PMID: 16393282</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Biological and medical sciences ; Celiac Disease - epidemiology ; Celiac Disease - psychology ; Colitis, Ulcerative - epidemiology ; Colitis, Ulcerative - psychology ; Crohn Disease - epidemiology ; Crohn Disease - psychology ; Digestive system ; Epidemiologic Methods ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Male ; Medical sciences ; Other diseases. Semiology ; Pharmacology. Drug treatments ; Prevalence ; Schizophrenia - epidemiology ; Schizophrenia - etiology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; United Kingdom - epidemiology</subject><ispartof>Alimentary pharmacology & therapeutics, 2006-01, Vol.23 (1), p.71-74</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3620-a16b596333f284da0865713b05f83234662b2c68cf2e98e63758115957bfb1983</citedby><cites>FETCH-LOGICAL-c3620-a16b596333f284da0865713b05f83234662b2c68cf2e98e63758115957bfb1983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2036.2006.02720.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2036.2006.02720.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,4010,27900,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17478367$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16393282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WEST, J.</creatorcontrib><creatorcontrib>LOGAN, R. F.</creatorcontrib><creatorcontrib>HUBBARD, R. B.</creatorcontrib><creatorcontrib>CARD, T. R.</creatorcontrib><title>Risk of schizophrenia in people with coeliac disease, ulcerative colitis and Crohn's disease: a general population‐based study</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background
Recently, interest has been revived in whether people with coeliac disease, in contrast to other inflammatory gastrointestinal diseases, have an increased risk of schizophrenia.
Aim
To compare the risk of schizophrenia in people diagnosed with coeliac disease, ulcerative colitis and Crohn's disease with the general population.
Methods
We used data from the UK General Practice Research Database. People with coeliac disease, Crohn's disease and ulcerative colitis were matched individually with five age‐, sex‐ and general practice‐matched controls. The prevalence of schizophrenia was calculated and compared between disease groups and their respective controls. We calculated odds ratios for schizophrenia using conditional logistic regression adjusting for smoking status.
Results
In people with coeliac disease, Crohn's disease and ulcerative colitis the prevalence of schizophrenia was 0.25%, 0.27% and 0.24%, respectively, compared with a general population prevalence of 0.37%. The adjusted odds ratios showed no association between schizophrenia and gastrointestinal disease (coeliac disease vs. controls 0.76, 95% CI: 0.41–1.4; Crohn's disease vs. controls 0.74, 95% CI: 0.44–1.3; ulcerative colitis 0.71, 95% CI: 0.44–1.1).
Conclusions Contrary to recent findings we found no evidence of an increased risk of schizophrenia in people with coeliac disease compared with the general population.</description><subject>Biological and medical sciences</subject><subject>Celiac Disease - epidemiology</subject><subject>Celiac Disease - psychology</subject><subject>Colitis, Ulcerative - epidemiology</subject><subject>Colitis, Ulcerative - psychology</subject><subject>Crohn Disease - epidemiology</subject><subject>Crohn Disease - psychology</subject><subject>Digestive system</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prevalence</subject><subject>Schizophrenia - epidemiology</subject><subject>Schizophrenia - etiology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>United Kingdom - epidemiology</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtu1DAUhi0EokPhFZA3wIakvkxsB4lFNSoXqRIIlbXlOCeMB08c7KTtsOoj9Bn7JHWYgW7x5lj6v__Y-hDClJQ0n5NNSbmoCka4KBkhoiRMMlJeP0KLf8FjtCBM1AVTlB-hZyltSCYlYU_RERW85kyxBbr55tJPHDqc7Nr9DsM6Qu8Mdj0eIAwe8JUb19gG8M5Y3LoEJsFbPHkL0YzuEnLm3egSNn2LVzGs-zfpL_cOG_wD-kx6PIRh8rkR-rub2yaHLU7j1O6eoyed8QleHOYx-v7h7GL1qTj_8vHz6vS8sFwwUhgqmqoWnPOOqWVriBKVpLwhVac440shWMOsULZjUCsQXFaK0qquZNM1tFb8GL3e7x1i-DVBGvXWJQvemx7ClLSQgiwrMYNqD9oYUorQ6SG6rYk7TYme7euNniXrWbKe7es_9vV1rr48vDE1W2gfigfdGXh1AEyyxnfR9NalB04upeJCZu79nrtyHnb__QF9-vVivvF72uihMQ</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>WEST, J.</creator><creator>LOGAN, R. F.</creator><creator>HUBBARD, R. B.</creator><creator>CARD, T. R.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200601</creationdate><title>Risk of schizophrenia in people with coeliac disease, ulcerative colitis and Crohn's disease: a general population‐based study</title><author>WEST, J. ; LOGAN, R. F. ; HUBBARD, R. B. ; CARD, T. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3620-a16b596333f284da0865713b05f83234662b2c68cf2e98e63758115957bfb1983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biological and medical sciences</topic><topic>Celiac Disease - epidemiology</topic><topic>Celiac Disease - psychology</topic><topic>Colitis, Ulcerative - epidemiology</topic><topic>Colitis, Ulcerative - psychology</topic><topic>Crohn Disease - epidemiology</topic><topic>Crohn Disease - psychology</topic><topic>Digestive system</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Prevalence</topic><topic>Schizophrenia - epidemiology</topic><topic>Schizophrenia - etiology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WEST, J.</creatorcontrib><creatorcontrib>LOGAN, R. F.</creatorcontrib><creatorcontrib>HUBBARD, R. B.</creatorcontrib><creatorcontrib>CARD, T. R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WEST, J.</au><au>LOGAN, R. F.</au><au>HUBBARD, R. B.</au><au>CARD, T. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of schizophrenia in people with coeliac disease, ulcerative colitis and Crohn's disease: a general population‐based study</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2006-01</date><risdate>2006</risdate><volume>23</volume><issue>1</issue><spage>71</spage><epage>74</epage><pages>71-74</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background
Recently, interest has been revived in whether people with coeliac disease, in contrast to other inflammatory gastrointestinal diseases, have an increased risk of schizophrenia.
Aim
To compare the risk of schizophrenia in people diagnosed with coeliac disease, ulcerative colitis and Crohn's disease with the general population.
Methods
We used data from the UK General Practice Research Database. People with coeliac disease, Crohn's disease and ulcerative colitis were matched individually with five age‐, sex‐ and general practice‐matched controls. The prevalence of schizophrenia was calculated and compared between disease groups and their respective controls. We calculated odds ratios for schizophrenia using conditional logistic regression adjusting for smoking status.
Results
In people with coeliac disease, Crohn's disease and ulcerative colitis the prevalence of schizophrenia was 0.25%, 0.27% and 0.24%, respectively, compared with a general population prevalence of 0.37%. The adjusted odds ratios showed no association between schizophrenia and gastrointestinal disease (coeliac disease vs. controls 0.76, 95% CI: 0.41–1.4; Crohn's disease vs. controls 0.74, 95% CI: 0.44–1.3; ulcerative colitis 0.71, 95% CI: 0.44–1.1).
Conclusions Contrary to recent findings we found no evidence of an increased risk of schizophrenia in people with coeliac disease compared with the general population.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16393282</pmid><doi>10.1111/j.1365-2036.2006.02720.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; IngentaConnect Open Access Journals; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences Celiac Disease - epidemiology Celiac Disease - psychology Colitis, Ulcerative - epidemiology Colitis, Ulcerative - psychology Crohn Disease - epidemiology Crohn Disease - psychology Digestive system Epidemiologic Methods Female Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Other diseases. Semiology Pharmacology. Drug treatments Prevalence Schizophrenia - epidemiology Schizophrenia - etiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus United Kingdom - epidemiology |
| title | Risk of schizophrenia in people with coeliac disease, ulcerative colitis and Crohn's disease: a general population‐based study |
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