Histological effects of esomeprazole therapy on the squamous epithelium of the distal oesophagus
Summary Background Proton pump inhibitor therapy has been reported to reduce proliferative changes of the oesophagus significantly in gastro‐oesophageal reflux disease (GERD). Aim To assess the histological effects of esomeprazole treatment on the oesophagus. Methods Data were derived from a subg...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2006-01, Vol.23 (2), p.313-319 |
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| creator | VIETH, M. KULIG, M. LEODOLTER, A. NAUCLÉR, E. JASPERSEN, D. LABENZ, J. MEYER‐SABELLEK, W. LIND, T. WILLICH, S. MALFERTHEINER, P. STOLTE, M. |
| description | Summary
Background Proton pump inhibitor therapy has been reported to reduce proliferative changes of the oesophagus significantly in gastro‐oesophageal reflux disease (GERD).
Aim To assess the histological effects of esomeprazole treatment on the oesophagus.
Methods Data were derived from a subgroup of patients participating in the proGERD study, who had either erosive reflux disease (n = 720) or non‐erosive reflux disease (n = 35) and who had biopsy data from two sites [(i) 2 cm above the z‐line and (ii) at the z‐line], obtained at baseline and following treatment with esomeprazole. Proliferative changes of the squamous epithelium were assessed histologically by measuring thickness of the basal cell layer and elongation of the papillae as a percentage of the whole epithelial thickness.
Results In erosive reflux disease patients, the thickness of the basal cell layer and length of the papillae pretreatment were associated with the severity of oesophagitis (P |
| doi_str_mv | 10.1111/j.1365-2036.2006.02752.x |
| format | Article |
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Background Proton pump inhibitor therapy has been reported to reduce proliferative changes of the oesophagus significantly in gastro‐oesophageal reflux disease (GERD).
Aim To assess the histological effects of esomeprazole treatment on the oesophagus.
Methods Data were derived from a subgroup of patients participating in the proGERD study, who had either erosive reflux disease (n = 720) or non‐erosive reflux disease (n = 35) and who had biopsy data from two sites [(i) 2 cm above the z‐line and (ii) at the z‐line], obtained at baseline and following treatment with esomeprazole. Proliferative changes of the squamous epithelium were assessed histologically by measuring thickness of the basal cell layer and elongation of the papillae as a percentage of the whole epithelial thickness.
Results In erosive reflux disease patients, the thickness of the basal cell layer and length of the papillae pretreatment were associated with the severity of oesophagitis (P < 0.05), at both biopsy sites. After esomeprazole treatment, baseline thickness and length of papillae were significantly reduced (P < 0.05) at both biopsy sites in non‐erosive reflux disease and erosive reflux disease patients (particularly those with Los Angeles grades C and D).
Conclusion This demonstrates a strong correlation between severity of GERD and histological parameters. Esomeprazole therapy resulted in clear reversal of proliferative changes observed prior to treatment in the squamous epithelium at both biopsy locations.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/j.1365-2036.2006.02752.x</identifier><identifier>PMID: 16393312</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Biological and medical sciences ; Biopsy - methods ; Cell Division - drug effects ; Digestive system ; Enzyme Inhibitors - therapeutic use ; Epithelial Cells - drug effects ; Epithelial Cells - pathology ; Epithelium - drug effects ; Epithelium - pathology ; Esomeprazole - therapeutic use ; Esophagitis, Peptic - drug therapy ; Esophagitis, Peptic - pathology ; Esophagoscopy - methods ; Esophagus - drug effects ; Esophagus - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastroesophageal Reflux - drug therapy ; Gastroesophageal Reflux - pathology ; Humans ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Prospective Studies ; Treatment Outcome</subject><ispartof>Alimentary pharmacology & therapeutics, 2006-01, Vol.23 (2), p.313-319</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4782-e523ed5c61ccad4f485a6a11c62b58d593d6578e3c515e42ddf2add8227606603</citedby><cites>FETCH-LOGICAL-c4782-e523ed5c61ccad4f485a6a11c62b58d593d6578e3c515e42ddf2add8227606603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2036.2006.02752.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2036.2006.02752.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17478397$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16393312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VIETH, M.</creatorcontrib><creatorcontrib>KULIG, M.</creatorcontrib><creatorcontrib>LEODOLTER, A.</creatorcontrib><creatorcontrib>NAUCLÉR, E.</creatorcontrib><creatorcontrib>JASPERSEN, D.</creatorcontrib><creatorcontrib>LABENZ, J.</creatorcontrib><creatorcontrib>MEYER‐SABELLEK, W.</creatorcontrib><creatorcontrib>LIND, T.</creatorcontrib><creatorcontrib>WILLICH, S.</creatorcontrib><creatorcontrib>MALFERTHEINER, P.</creatorcontrib><creatorcontrib>STOLTE, M.</creatorcontrib><title>Histological effects of esomeprazole therapy on the squamous epithelium of the distal oesophagus</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background Proton pump inhibitor therapy has been reported to reduce proliferative changes of the oesophagus significantly in gastro‐oesophageal reflux disease (GERD).
Aim To assess the histological effects of esomeprazole treatment on the oesophagus.
Methods Data were derived from a subgroup of patients participating in the proGERD study, who had either erosive reflux disease (n = 720) or non‐erosive reflux disease (n = 35) and who had biopsy data from two sites [(i) 2 cm above the z‐line and (ii) at the z‐line], obtained at baseline and following treatment with esomeprazole. Proliferative changes of the squamous epithelium were assessed histologically by measuring thickness of the basal cell layer and elongation of the papillae as a percentage of the whole epithelial thickness.
Results In erosive reflux disease patients, the thickness of the basal cell layer and length of the papillae pretreatment were associated with the severity of oesophagitis (P < 0.05), at both biopsy sites. After esomeprazole treatment, baseline thickness and length of papillae were significantly reduced (P < 0.05) at both biopsy sites in non‐erosive reflux disease and erosive reflux disease patients (particularly those with Los Angeles grades C and D).
Conclusion This demonstrates a strong correlation between severity of GERD and histological parameters. Esomeprazole therapy resulted in clear reversal of proliferative changes observed prior to treatment in the squamous epithelium at both biopsy locations.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy - methods</subject><subject>Cell Division - drug effects</subject><subject>Digestive system</subject><subject>Enzyme Inhibitors - therapeutic use</subject><subject>Epithelial Cells - drug effects</subject><subject>Epithelial Cells - pathology</subject><subject>Epithelium - drug effects</subject><subject>Epithelium - pathology</subject><subject>Esomeprazole - therapeutic use</subject><subject>Esophagitis, Peptic - drug therapy</subject><subject>Esophagitis, Peptic - pathology</subject><subject>Esophagoscopy - methods</subject><subject>Esophagus - drug effects</subject><subject>Esophagus - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastroesophageal Reflux - drug therapy</subject><subject>Gastroesophageal Reflux - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Treatment Outcome</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctOwzAQRS0EglL4BZQN7BL8iB9dsKgqXlIlWJS1ce1JSZXUadwIytfj0AqW4I3HmnOvR3cQSgjOSDzXy4wwwVOKmcgoxiLDVHKafRygwU_jEA0wFaOUKsJO0GkISxxJiekxOiGCjRgjdIBeH8qw8ZVflNZUCRQF2E1IfJFA8DU0rfn0FSSbN2hNs038qi-TsO5M7buQQFPGd1V2dS_pWy7aRSMf5c2bWXThDB0Vpgpwvr-H6OXudjZ5SKdP94-T8TS1uVQ0BU4ZOG4Fsda4vMgVN8IQYgWdc-X4iDnBpQJmOeGQU-cKapxTlEqBhcBsiK52vk3r1x2Eja7LYKGqzAriqFpELs-V-BOkWAnJJY-g2oG29SG0UOimLWvTbjXBul-DXuo-bd2nrfs16O816I8ovdj_0c1rcL_Cfe4RuNwDJsTgi9asbBl-ORlDYSMZuZsd915WsP33AHr8POsr9gXKdaQf</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>VIETH, M.</creator><creator>KULIG, M.</creator><creator>LEODOLTER, A.</creator><creator>NAUCLÉR, E.</creator><creator>JASPERSEN, D.</creator><creator>LABENZ, J.</creator><creator>MEYER‐SABELLEK, W.</creator><creator>LIND, T.</creator><creator>WILLICH, S.</creator><creator>MALFERTHEINER, P.</creator><creator>STOLTE, M.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200601</creationdate><title>Histological effects of esomeprazole therapy on the squamous epithelium of the distal oesophagus</title><author>VIETH, M. ; KULIG, M. ; LEODOLTER, A. ; NAUCLÉR, E. ; JASPERSEN, D. ; LABENZ, J. ; MEYER‐SABELLEK, W. ; LIND, T. ; WILLICH, S. ; MALFERTHEINER, P. ; STOLTE, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4782-e523ed5c61ccad4f485a6a11c62b58d593d6578e3c515e42ddf2add8227606603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biopsy - methods</topic><topic>Cell Division - drug effects</topic><topic>Digestive system</topic><topic>Enzyme Inhibitors - therapeutic use</topic><topic>Epithelial Cells - drug effects</topic><topic>Epithelial Cells - pathology</topic><topic>Epithelium - drug effects</topic><topic>Epithelium - pathology</topic><topic>Esomeprazole - therapeutic use</topic><topic>Esophagitis, Peptic - drug therapy</topic><topic>Esophagitis, Peptic - pathology</topic><topic>Esophagoscopy - methods</topic><topic>Esophagus - drug effects</topic><topic>Esophagus - pathology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastroesophageal Reflux - drug therapy</topic><topic>Gastroesophageal Reflux - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VIETH, M.</creatorcontrib><creatorcontrib>KULIG, M.</creatorcontrib><creatorcontrib>LEODOLTER, A.</creatorcontrib><creatorcontrib>NAUCLÉR, E.</creatorcontrib><creatorcontrib>JASPERSEN, D.</creatorcontrib><creatorcontrib>LABENZ, J.</creatorcontrib><creatorcontrib>MEYER‐SABELLEK, W.</creatorcontrib><creatorcontrib>LIND, T.</creatorcontrib><creatorcontrib>WILLICH, S.</creatorcontrib><creatorcontrib>MALFERTHEINER, P.</creatorcontrib><creatorcontrib>STOLTE, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VIETH, M.</au><au>KULIG, M.</au><au>LEODOLTER, A.</au><au>NAUCLÉR, E.</au><au>JASPERSEN, D.</au><au>LABENZ, J.</au><au>MEYER‐SABELLEK, W.</au><au>LIND, T.</au><au>WILLICH, S.</au><au>MALFERTHEINER, P.</au><au>STOLTE, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histological effects of esomeprazole therapy on the squamous epithelium of the distal oesophagus</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2006-01</date><risdate>2006</risdate><volume>23</volume><issue>2</issue><spage>313</spage><epage>319</epage><pages>313-319</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background Proton pump inhibitor therapy has been reported to reduce proliferative changes of the oesophagus significantly in gastro‐oesophageal reflux disease (GERD).
Aim To assess the histological effects of esomeprazole treatment on the oesophagus.
Methods Data were derived from a subgroup of patients participating in the proGERD study, who had either erosive reflux disease (n = 720) or non‐erosive reflux disease (n = 35) and who had biopsy data from two sites [(i) 2 cm above the z‐line and (ii) at the z‐line], obtained at baseline and following treatment with esomeprazole. Proliferative changes of the squamous epithelium were assessed histologically by measuring thickness of the basal cell layer and elongation of the papillae as a percentage of the whole epithelial thickness.
Results In erosive reflux disease patients, the thickness of the basal cell layer and length of the papillae pretreatment were associated with the severity of oesophagitis (P < 0.05), at both biopsy sites. After esomeprazole treatment, baseline thickness and length of papillae were significantly reduced (P < 0.05) at both biopsy sites in non‐erosive reflux disease and erosive reflux disease patients (particularly those with Los Angeles grades C and D).
Conclusion This demonstrates a strong correlation between severity of GERD and histological parameters. Esomeprazole therapy resulted in clear reversal of proliferative changes observed prior to treatment in the squamous epithelium at both biopsy locations.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16393312</pmid><doi>10.1111/j.1365-2036.2006.02752.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection) |
| subjects | Adult Biological and medical sciences Biopsy - methods Cell Division - drug effects Digestive system Enzyme Inhibitors - therapeutic use Epithelial Cells - drug effects Epithelial Cells - pathology Epithelium - drug effects Epithelium - pathology Esomeprazole - therapeutic use Esophagitis, Peptic - drug therapy Esophagitis, Peptic - pathology Esophagoscopy - methods Esophagus - drug effects Esophagus - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Gastroesophageal Reflux - drug therapy Gastroesophageal Reflux - pathology Humans Male Medical sciences Pharmacology. Drug treatments Prospective Studies Treatment Outcome |
| title | Histological effects of esomeprazole therapy on the squamous epithelium of the distal oesophagus |
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