Auto-Redox Reaction: Tin(II) Chloride-Mediated One-Step Reductive Cyclization Leading to the Synthesis of Novel Biheterocyclic 5,6-Dihydro-quinazolino[4,3-b]quinazolin-8-ones with Three-Point Diversity

A tin(II) chloride-mediated short, efficient, and practical regioselective synthesis of biheterocyclic 5,6-dihydro-quinazolino[4,3-b]quinazolin-8-ones with three-point diversity is reported. A one-step reductive transformation of 2-(2-nitrophenyl)-3H-quinazolin-4-one in various alcohols furnished th...

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Veröffentlicht in:	Journal of organic chemistry 2006-01, Vol.71 (1), p.382-385
Hauptverfasser:	Roy, Abhijeet Deb, Subramanian, Arunachalam, Roy, Raja
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Chlorides - chemistry Cyclization Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Magnetic Resonance Spectroscopy Molecular Structure Organic chemistry Oxidation-Reduction Preparations and properties Quinazolines - chemical synthesis Quinazolines - chemistry Tin - chemistry
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Zusammenfassung:	A tin(II) chloride-mediated short, efficient, and practical regioselective synthesis of biheterocyclic 5,6-dihydro-quinazolino[4,3-b]quinazolin-8-ones with three-point diversity is reported. A one-step reductive transformation of 2-(2-nitrophenyl)-3H-quinazolin-4-one in various alcohols furnished the desired tetracyclic product in good yields with high purity.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo0518912