Seroepidemiology of Klebsiella pneumoniae in an Australian Tertiary Hospital and Its Implications for Vaccine Development
The aim of this study was to determine the diversity of Klebsiella pneumoniae capsular serotypes in an Australian setting. Consecutive (n = 293) nonrepetitive isolates of K. pneumoniae from a large teaching hospital laboratory were analyzed. The majority of isolates were from urinary specimens (60.8...
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| Veröffentlicht in: | Journal of Clinical Microbiology 2006, Vol.44 (1), p.102-107 |
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| creator | Jenney, Adam W Clements, Abigail Farn, Jacinta L Wijburg, Odilia L McGlinchey, Andrew Spelman, Denis W Pitt, Tyrone L Kaufmann, Mary E Liolios, Lisa Moloney, Margaret B Wesselingh, Steven L Strugnell, Richard A |
| description | The aim of this study was to determine the diversity of Klebsiella pneumoniae capsular serotypes in an Australian setting. Consecutive (n = 293) nonrepetitive isolates of K. pneumoniae from a large teaching hospital laboratory were analyzed. The majority of isolates were from urinary specimens (60.8%); the next most common source was sputum (14.3%), followed by blood (14%). Serotyping revealed a wide range of capsule types. K54 (17.1%), K28 (4.1%), and K17 (3.1%) were the most common, and K54 isolates displayed a high degree of clonality, suggesting a common, nosocomial source. In vitro, one K54 isolate was more adherent to urinary catheters and HEp-2 cells than four other tested isolates; it was slightly more resistant to chlorhexidine but was more susceptible to drying than heavily encapsulated strains. This is the first seroprevalence survey of K. pneumoniae to be performed on Australian isolates, and the high level of diversity of serotypes suggests that capsule-based immunoprophylaxis might not be useful for Australia. In addition there are significant differences in the predominance of specific serotypes compared to the results of surveys performed overseas, which has important implications for capsule-based immunoprophylaxis aimed at a global market. |
| doi_str_mv | 10.1128/JCM.44.1.102-107.2006 |
| format | Article |
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Consecutive (n = 293) nonrepetitive isolates of K. pneumoniae from a large teaching hospital laboratory were analyzed. The majority of isolates were from urinary specimens (60.8%); the next most common source was sputum (14.3%), followed by blood (14%). Serotyping revealed a wide range of capsule types. K54 (17.1%), K28 (4.1%), and K17 (3.1%) were the most common, and K54 isolates displayed a high degree of clonality, suggesting a common, nosocomial source. In vitro, one K54 isolate was more adherent to urinary catheters and HEp-2 cells than four other tested isolates; it was slightly more resistant to chlorhexidine but was more susceptible to drying than heavily encapsulated strains. This is the first seroprevalence survey of K. pneumoniae to be performed on Australian isolates, and the high level of diversity of serotypes suggests that capsule-based immunoprophylaxis might not be useful for Australia. In addition there are significant differences in the predominance of specific serotypes compared to the results of surveys performed overseas, which has important implications for capsule-based immunoprophylaxis aimed at a global market.</description><identifier>ISSN: 0095-1137</identifier><identifier>EISSN: 1098-660X</identifier><identifier>EISSN: 1098-5530</identifier><identifier>DOI: 10.1128/JCM.44.1.102-107.2006</identifier><identifier>PMID: 16390956</identifier><identifier>CODEN: JCMIDW</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Antibodies, Bacterial - blood ; Applied microbiology ; Australia - epidemiology ; Bacterial Vaccines - administration & dosage ; Bacterial Vaccines - immunology ; Bacteriology ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Hospitals ; Humans ; Infectious diseases ; Klebsiella Infections - epidemiology ; Klebsiella Infections - mortality ; Klebsiella Infections - prevention & control ; Klebsiella pneumoniae ; Klebsiella pneumoniae - classification ; Klebsiella pneumoniae - immunology ; Medical sciences ; Microbiology ; Miscellaneous ; Seroepidemiologic Studies ; Sputum - microbiology ; Terminal Care ; Urine - microbiology ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Journal of Clinical Microbiology, 2006, Vol.44 (1), p.102-107</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright © 2006, American Society for Microbiology 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-ab9855d9ca4f46a5c3739a6030072a613a2e114b82282e52e735ab9af9274d433</citedby><cites>FETCH-LOGICAL-c519t-ab9855d9ca4f46a5c3739a6030072a613a2e114b82282e52e735ab9af9274d433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1351949/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1351949/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,3175,3176,4010,27902,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17474612$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16390956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jenney, Adam W</creatorcontrib><creatorcontrib>Clements, Abigail</creatorcontrib><creatorcontrib>Farn, Jacinta L</creatorcontrib><creatorcontrib>Wijburg, Odilia L</creatorcontrib><creatorcontrib>McGlinchey, Andrew</creatorcontrib><creatorcontrib>Spelman, Denis W</creatorcontrib><creatorcontrib>Pitt, Tyrone L</creatorcontrib><creatorcontrib>Kaufmann, Mary E</creatorcontrib><creatorcontrib>Liolios, Lisa</creatorcontrib><creatorcontrib>Moloney, Margaret B</creatorcontrib><creatorcontrib>Wesselingh, Steven L</creatorcontrib><creatorcontrib>Strugnell, Richard A</creatorcontrib><title>Seroepidemiology of Klebsiella pneumoniae in an Australian Tertiary Hospital and Its Implications for Vaccine Development</title><title>Journal of Clinical Microbiology</title><addtitle>J Clin Microbiol</addtitle><description>The aim of this study was to determine the diversity of Klebsiella pneumoniae capsular serotypes in an Australian setting. Consecutive (n = 293) nonrepetitive isolates of K. pneumoniae from a large teaching hospital laboratory were analyzed. The majority of isolates were from urinary specimens (60.8%); the next most common source was sputum (14.3%), followed by blood (14%). Serotyping revealed a wide range of capsule types. K54 (17.1%), K28 (4.1%), and K17 (3.1%) were the most common, and K54 isolates displayed a high degree of clonality, suggesting a common, nosocomial source. In vitro, one K54 isolate was more adherent to urinary catheters and HEp-2 cells than four other tested isolates; it was slightly more resistant to chlorhexidine but was more susceptible to drying than heavily encapsulated strains. This is the first seroprevalence survey of K. pneumoniae to be performed on Australian isolates, and the high level of diversity of serotypes suggests that capsule-based immunoprophylaxis might not be useful for Australia. In addition there are significant differences in the predominance of specific serotypes compared to the results of surveys performed overseas, which has important implications for capsule-based immunoprophylaxis aimed at a global market.</description><subject>Antibodies, Bacterial - blood</subject><subject>Applied microbiology</subject><subject>Australia - epidemiology</subject><subject>Bacterial Vaccines - administration & dosage</subject><subject>Bacterial Vaccines - immunology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Klebsiella Infections - epidemiology</subject><subject>Klebsiella Infections - mortality</subject><subject>Klebsiella Infections - prevention & control</subject><subject>Klebsiella pneumoniae</subject><subject>Klebsiella pneumoniae - classification</subject><subject>Klebsiella pneumoniae - immunology</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Seroepidemiologic Studies</subject><subject>Sputum - microbiology</subject><subject>Terminal Care</subject><subject>Urine - microbiology</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0095-1137</issn><issn>1098-660X</issn><issn>1098-5530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEUhUcIRNPCTwC8obsZfP2c2SBV4dFAEYu2iJ1143gSVzPjwZ4U5d_jKFELKxaWLd_vnnvsUxSvgFYArH73Zf6tEqKCCigrgeqKUaqeFDOgTV0qRX8-LWaUNrIE4PqkOE3pjlIQQsrnxQko3uSamhW7axeDG_3K9T50Yb0joSVfO7dM3nUdknFw2z4MHh3xA8GBXGzTFLHz-Xjj4uQx7shlSKOfsMv1FVlMiSz6sfMWJx-GRNoQyQ-01g-OfHD3rgtj74bpRfGsxS65l8f9rLj99PFmflleff-8mF9clVZCM5W4bGopV41F0QqF0nLNG1SUU6oZKuDIHIBY1ozVzEnmNJe5B9uGabESnJ8V7w-643bZu5XNo7N_M0bfZ-8moDf_Vga_Metwb4BnA6LJAudHgRh-bV2aTO-T3f_O4MI2GaUVFTQ7-R8IWkidfWdQHkAbQ0rRtQ9ugJp9uiana4QwkC9YXtrs0819r_9-ymPXMc4MvD0CmCx2bcTB-vTIaaGFApY5cuA2fr357aMzmHpzZ_uHoRl5c0BaDAbXMcvcXjMKnAIVutGS_wE2CMPf</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Jenney, Adam W</creator><creator>Clements, Abigail</creator><creator>Farn, Jacinta L</creator><creator>Wijburg, Odilia L</creator><creator>McGlinchey, Andrew</creator><creator>Spelman, Denis W</creator><creator>Pitt, Tyrone L</creator><creator>Kaufmann, Mary E</creator><creator>Liolios, Lisa</creator><creator>Moloney, Margaret B</creator><creator>Wesselingh, Steven L</creator><creator>Strugnell, Richard A</creator><general>American Society for Microbiology</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2006</creationdate><title>Seroepidemiology of Klebsiella pneumoniae in an Australian Tertiary Hospital and Its Implications for Vaccine Development</title><author>Jenney, Adam W ; Clements, Abigail ; Farn, Jacinta L ; Wijburg, Odilia L ; McGlinchey, Andrew ; Spelman, Denis W ; Pitt, Tyrone L ; Kaufmann, Mary E ; Liolios, Lisa ; Moloney, Margaret B ; Wesselingh, Steven L ; Strugnell, Richard A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-ab9855d9ca4f46a5c3739a6030072a613a2e114b82282e52e735ab9af9274d433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Antibodies, Bacterial - blood</topic><topic>Applied microbiology</topic><topic>Australia - epidemiology</topic><topic>Bacterial Vaccines - administration & dosage</topic><topic>Bacterial Vaccines - immunology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Klebsiella Infections - epidemiology</topic><topic>Klebsiella Infections - mortality</topic><topic>Klebsiella Infections - prevention & control</topic><topic>Klebsiella pneumoniae</topic><topic>Klebsiella pneumoniae - classification</topic><topic>Klebsiella pneumoniae - immunology</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Seroepidemiologic Studies</topic><topic>Sputum - microbiology</topic><topic>Terminal Care</topic><topic>Urine - microbiology</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jenney, Adam W</creatorcontrib><creatorcontrib>Clements, Abigail</creatorcontrib><creatorcontrib>Farn, Jacinta L</creatorcontrib><creatorcontrib>Wijburg, Odilia L</creatorcontrib><creatorcontrib>McGlinchey, Andrew</creatorcontrib><creatorcontrib>Spelman, Denis W</creatorcontrib><creatorcontrib>Pitt, Tyrone L</creatorcontrib><creatorcontrib>Kaufmann, Mary E</creatorcontrib><creatorcontrib>Liolios, Lisa</creatorcontrib><creatorcontrib>Moloney, Margaret B</creatorcontrib><creatorcontrib>Wesselingh, Steven L</creatorcontrib><creatorcontrib>Strugnell, Richard A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jenney, Adam W</au><au>Clements, Abigail</au><au>Farn, Jacinta L</au><au>Wijburg, Odilia L</au><au>McGlinchey, Andrew</au><au>Spelman, Denis W</au><au>Pitt, Tyrone L</au><au>Kaufmann, Mary E</au><au>Liolios, Lisa</au><au>Moloney, Margaret B</au><au>Wesselingh, Steven L</au><au>Strugnell, Richard A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seroepidemiology of Klebsiella pneumoniae in an Australian Tertiary Hospital and Its Implications for Vaccine Development</atitle><jtitle>Journal of Clinical Microbiology</jtitle><addtitle>J Clin Microbiol</addtitle><date>2006</date><risdate>2006</risdate><volume>44</volume><issue>1</issue><spage>102</spage><epage>107</epage><pages>102-107</pages><issn>0095-1137</issn><eissn>1098-660X</eissn><eissn>1098-5530</eissn><coden>JCMIDW</coden><abstract>The aim of this study was to determine the diversity of Klebsiella pneumoniae capsular serotypes in an Australian setting. Consecutive (n = 293) nonrepetitive isolates of K. pneumoniae from a large teaching hospital laboratory were analyzed. The majority of isolates were from urinary specimens (60.8%); the next most common source was sputum (14.3%), followed by blood (14%). Serotyping revealed a wide range of capsule types. K54 (17.1%), K28 (4.1%), and K17 (3.1%) were the most common, and K54 isolates displayed a high degree of clonality, suggesting a common, nosocomial source. In vitro, one K54 isolate was more adherent to urinary catheters and HEp-2 cells than four other tested isolates; it was slightly more resistant to chlorhexidine but was more susceptible to drying than heavily encapsulated strains. This is the first seroprevalence survey of K. pneumoniae to be performed on Australian isolates, and the high level of diversity of serotypes suggests that capsule-based immunoprophylaxis might not be useful for Australia. In addition there are significant differences in the predominance of specific serotypes compared to the results of surveys performed overseas, which has important implications for capsule-based immunoprophylaxis aimed at a global market.</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>16390956</pmid><doi>10.1128/JCM.44.1.102-107.2006</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antibodies, Bacterial - blood Applied microbiology Australia - epidemiology Bacterial Vaccines - administration & dosage Bacterial Vaccines - immunology Bacteriology Biological and medical sciences Fundamental and applied biological sciences. Psychology Hospitals Humans Infectious diseases Klebsiella Infections - epidemiology Klebsiella Infections - mortality Klebsiella Infections - prevention & control Klebsiella pneumoniae Klebsiella pneumoniae - classification Klebsiella pneumoniae - immunology Medical sciences Microbiology Miscellaneous Seroepidemiologic Studies Sputum - microbiology Terminal Care Urine - microbiology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Seroepidemiology of Klebsiella pneumoniae in an Australian Tertiary Hospital and Its Implications for Vaccine Development |
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