Monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) induces apoptosis in primary renal cell carcinoma cells in vitro and inhibits tumor growth in vivo

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in a variety of tumor cells through two of its receptors: TRAIL-R1 and TRAIL-R2. We investigate the susceptibility of human renal cell carcinoma (RCC) cells to TRM-1 and HGS-ETR2, 2 human monoclonal agonistic antibodi...

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Veröffentlicht in:	International journal of oncology 2006-02, Vol.28 (2), p.421-430
Hauptverfasser:	ZENG, Y, WU, X. X, FISCELLA, M, SHIMADA, O, HUMPHREYS, R, ALBERT, V, KAKEHI, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - pharmacology Apoptosis - immunology Biological and medical sciences Carcinoma, Renal Cell - pathology Carcinoma, Renal Cell - prevention & control Caspase Inhibitors Caspases - metabolism Cell Culture Techniques Cell Line, Tumor Cell Membrane - metabolism Cell Survival Enzyme Inhibitors - pharmacology Humans Kidney Neoplasms - pathology Kidney Neoplasms - prevention & control Kidneys Male Medical sciences Mice Mice, Nude Mice, SCID Nephrology. Urinary tract diseases Receptors, TNF-Related Apoptosis-Inducing Ligand - biosynthesis Receptors, TNF-Related Apoptosis-Inducing Ligand - immunology Receptors, Tumor Necrosis Factor - immunology Receptors, Tumor Necrosis Factor - metabolism TNF-Related Apoptosis-Inducing Ligand - pharmacology Tumors Tumors of the urinary system Xenograft Model Antitumor Assays
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