Genotypic interaction between DRD4 and DAT1 loci is a high risk factor for attention-deficit/hyperactivity disorder in Chilean families
Attention‐deficit/hyperactivity disorder, ADHD [MIM 126452], is a common, highly heritable neurobiological disorder of childhood onset, characterized by hyperactivity, impulsiveness, and/or inattentiveness. As part of an ongoing study of ADHD, we carried out a family‐based discordant sib‐pair analys...
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| Veröffentlicht in: | American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2006-01, Vol.141B (1), p.51-54 |
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| container_title | American journal of medical genetics. Part B, Neuropsychiatric genetics |
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| creator | Carrasco, Ximena Rothhammer, Paula Moraga, Mauricio Henríquez, Hugo Chakraborty, Ranajit Aboitiz, Francisco Rothhammer, Francisco |
| description | Attention‐deficit/hyperactivity disorder, ADHD [MIM 126452], is a common, highly heritable neurobiological disorder of childhood onset, characterized by hyperactivity, impulsiveness, and/or inattentiveness. As part of an ongoing study of ADHD, we carried out a family‐based discordant sib‐pair analysis to detect possible associations between dopamine receptor D4 (DRD4) and dopamine transporter 1 (DAT1) polymorphisms and ADHD in Chilean families. Both loci individually classified as homozygotes or heterozygotes for the DRD4 7‐repeat and DAT1 10‐repeat alleles, did not exhibit genotype frequency differences between affected children and their healthy siblings (Fisher's exact test P > 0.25 in both cases). However, the simultaneous presence of both DRD4 7‐repeat heterozygosity and DAT1 10 allele homozygosity were significantly higher (34.6%) in cases (26), compared with their unaffected siblings (25) (4%; Fisher's exact test P = 0.0096; odds‐ratio, OR = 12.71). Increased density of dopamine transporter in ADHD brains, along with abundance of 7‐repeat D4 receptors in prefrontal cortex, which is impaired in ADHD patients, make the observed gene–gene interaction worthy of further incisive studies. © 2005 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajmg.b.30259 |
| format | Article |
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As part of an ongoing study of ADHD, we carried out a family‐based discordant sib‐pair analysis to detect possible associations between dopamine receptor D4 (DRD4) and dopamine transporter 1 (DAT1) polymorphisms and ADHD in Chilean families. Both loci individually classified as homozygotes or heterozygotes for the DRD4 7‐repeat and DAT1 10‐repeat alleles, did not exhibit genotype frequency differences between affected children and their healthy siblings (Fisher's exact test P > 0.25 in both cases). However, the simultaneous presence of both DRD4 7‐repeat heterozygosity and DAT1 10 allele homozygosity were significantly higher (34.6%) in cases (26), compared with their unaffected siblings (25) (4%; Fisher's exact test P = 0.0096; odds‐ratio, OR = 12.71). Increased density of dopamine transporter in ADHD brains, along with abundance of 7‐repeat D4 receptors in prefrontal cortex, which is impaired in ADHD patients, make the observed gene–gene interaction worthy of further incisive studies. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 1552-4841</identifier><identifier>EISSN: 1552-485X</identifier><identifier>DOI: 10.1002/ajmg.b.30259</identifier><identifier>PMID: 16342279</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>ADHD ; Adolescent ; Alleles ; Association with (?) ; Attention Deficit Disorder with Hyperactivity - genetics ; Child ; Chile ; DAT1 ; Dopamine Plasma Membrane Transport Proteins - genetics ; DRD4 ; Family Health ; Female ; Gene Frequency ; Genotype ; genotypic interaction ; Humans ; Male ; Polymorphism, Genetic ; Receptors, Dopamine D4 - genetics ; Risk Factors</subject><ispartof>American journal of medical genetics. Part B, Neuropsychiatric genetics, 2006-01, Vol.141B (1), p.51-54</ispartof><rights>Copyright © 2005 Wiley‐Liss, Inc.</rights><rights>(c) 2005 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4029-b75a07dd637d11b625bee5519ae7796b02b465359e423cd1c611101e352f71eb3</citedby><cites>FETCH-LOGICAL-c4029-b75a07dd637d11b625bee5519ae7796b02b465359e423cd1c611101e352f71eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajmg.b.30259$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajmg.b.30259$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16342279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carrasco, Ximena</creatorcontrib><creatorcontrib>Rothhammer, Paula</creatorcontrib><creatorcontrib>Moraga, Mauricio</creatorcontrib><creatorcontrib>Henríquez, Hugo</creatorcontrib><creatorcontrib>Chakraborty, Ranajit</creatorcontrib><creatorcontrib>Aboitiz, Francisco</creatorcontrib><creatorcontrib>Rothhammer, Francisco</creatorcontrib><title>Genotypic interaction between DRD4 and DAT1 loci is a high risk factor for attention-deficit/hyperactivity disorder in Chilean families</title><title>American journal of medical genetics. Part B, Neuropsychiatric genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>Attention‐deficit/hyperactivity disorder, ADHD [MIM 126452], is a common, highly heritable neurobiological disorder of childhood onset, characterized by hyperactivity, impulsiveness, and/or inattentiveness. As part of an ongoing study of ADHD, we carried out a family‐based discordant sib‐pair analysis to detect possible associations between dopamine receptor D4 (DRD4) and dopamine transporter 1 (DAT1) polymorphisms and ADHD in Chilean families. Both loci individually classified as homozygotes or heterozygotes for the DRD4 7‐repeat and DAT1 10‐repeat alleles, did not exhibit genotype frequency differences between affected children and their healthy siblings (Fisher's exact test P > 0.25 in both cases). However, the simultaneous presence of both DRD4 7‐repeat heterozygosity and DAT1 10 allele homozygosity were significantly higher (34.6%) in cases (26), compared with their unaffected siblings (25) (4%; Fisher's exact test P = 0.0096; odds‐ratio, OR = 12.71). Increased density of dopamine transporter in ADHD brains, along with abundance of 7‐repeat D4 receptors in prefrontal cortex, which is impaired in ADHD patients, make the observed gene–gene interaction worthy of further incisive studies. © 2005 Wiley‐Liss, Inc.</description><subject>ADHD</subject><subject>Adolescent</subject><subject>Alleles</subject><subject>Association with (?)</subject><subject>Attention Deficit Disorder with Hyperactivity - genetics</subject><subject>Child</subject><subject>Chile</subject><subject>DAT1</subject><subject>Dopamine Plasma Membrane Transport Proteins - genetics</subject><subject>DRD4</subject><subject>Family Health</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>genotypic interaction</subject><subject>Humans</subject><subject>Male</subject><subject>Polymorphism, Genetic</subject><subject>Receptors, Dopamine D4 - genetics</subject><subject>Risk Factors</subject><issn>1552-4841</issn><issn>1552-485X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhSNERUthxxp5xYpMff0Tk-VoBgK0UyQ0CHaWndx03OZnansoeQJemwyZll1ZWNeL73xX9kmSV0BnQCk7M9ft1czOOGUyf5KcgJQsFe_kj6cPdwHHyfMQrinlVCr1LDmGjAvGVH6S_C6w6-OwdSVxXURvyuj6jliMd4gdWX5dCmK6iiznayBNXzriAjFk4642xLtwQ-ox0XtSj8fEiN0-nlZYu9LFs82wnZQ_XRxI5ULvK_TjJrLYuAZNN8Zb1zgML5Kj2jQBXx7mafLtw_v14mN68aX4tJhfpKWgLE-tkoaqqsq4qgBsxqRFlBJyg0rlmaXMikxymaNgvKygzACAAnLJagVo-WnyZvJufX-7wxB160KJTWM67HdBZyqjDDL6XxByxUFIGMG3E1j6PgSPtd561xo_aKB635DeN6St_tvQiL8-eHe2xeoffKhkBPgE3I0_NDwq0_PPq-Jem04pFyL-ekgZfzM-iSupv18WulgJsYLztb7kfwCjLqx8</recordid><startdate>20060105</startdate><enddate>20060105</enddate><creator>Carrasco, Ximena</creator><creator>Rothhammer, Paula</creator><creator>Moraga, Mauricio</creator><creator>Henríquez, Hugo</creator><creator>Chakraborty, Ranajit</creator><creator>Aboitiz, Francisco</creator><creator>Rothhammer, Francisco</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060105</creationdate><title>Genotypic interaction between DRD4 and DAT1 loci is a high risk factor for attention-deficit/hyperactivity disorder in Chilean families</title><author>Carrasco, Ximena ; Rothhammer, Paula ; Moraga, Mauricio ; Henríquez, Hugo ; Chakraborty, Ranajit ; Aboitiz, Francisco ; Rothhammer, Francisco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4029-b75a07dd637d11b625bee5519ae7796b02b465359e423cd1c611101e352f71eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>ADHD</topic><topic>Adolescent</topic><topic>Alleles</topic><topic>Association with (?)</topic><topic>Attention Deficit Disorder with Hyperactivity - genetics</topic><topic>Child</topic><topic>Chile</topic><topic>DAT1</topic><topic>Dopamine Plasma Membrane Transport Proteins - genetics</topic><topic>DRD4</topic><topic>Family Health</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>genotypic interaction</topic><topic>Humans</topic><topic>Male</topic><topic>Polymorphism, Genetic</topic><topic>Receptors, Dopamine D4 - genetics</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carrasco, Ximena</creatorcontrib><creatorcontrib>Rothhammer, Paula</creatorcontrib><creatorcontrib>Moraga, Mauricio</creatorcontrib><creatorcontrib>Henríquez, Hugo</creatorcontrib><creatorcontrib>Chakraborty, Ranajit</creatorcontrib><creatorcontrib>Aboitiz, Francisco</creatorcontrib><creatorcontrib>Rothhammer, Francisco</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of medical genetics. 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However, the simultaneous presence of both DRD4 7‐repeat heterozygosity and DAT1 10 allele homozygosity were significantly higher (34.6%) in cases (26), compared with their unaffected siblings (25) (4%; Fisher's exact test P = 0.0096; odds‐ratio, OR = 12.71). Increased density of dopamine transporter in ADHD brains, along with abundance of 7‐repeat D4 receptors in prefrontal cortex, which is impaired in ADHD patients, make the observed gene–gene interaction worthy of further incisive studies. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16342279</pmid><doi>10.1002/ajmg.b.30259</doi><tpages>4</tpages></addata></record> |
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| subjects | ADHD Adolescent Alleles Association with (?) Attention Deficit Disorder with Hyperactivity - genetics Child Chile DAT1 Dopamine Plasma Membrane Transport Proteins - genetics DRD4 Family Health Female Gene Frequency Genotype genotypic interaction Humans Male Polymorphism, Genetic Receptors, Dopamine D4 - genetics Risk Factors |
| title | Genotypic interaction between DRD4 and DAT1 loci is a high risk factor for attention-deficit/hyperactivity disorder in Chilean families |
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