Two-Photon Imaging Reveals Somatodendritic Chloride Gradient in Retinal ON-Type Bipolar Cells Expressing the Biosensor Clomeleon

A somatodendritic gradient of Cl − concentration ([Cl −] i) has been postulated to generate GABA-evoked responses of different polarity in retinal bipolar cells, hyperpolarizing in OFF cells with low dendritic [Cl −] i, and depolarizing in ON cells with high dendritic [Cl −] i. As glutamate released...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2006-01, Vol.49 (1), p.81-94
Hauptverfasser:	Duebel, Jens, Haverkamp, Silke, Schleich, Wolfram, Feng, Guoping, Augustine, George J., Kuner, Thomas, Euler, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biosensing Techniques Calibration Chlorides - metabolism Dendrites - metabolism Diagnostic Imaging Fish Frogs GABA Agents - pharmacology gamma-Aminobutyric Acid - pharmacology Homeostasis Intracellular Membranes - metabolism Mice Mice, Transgenic - genetics MOLNEURO Osmolar Concentration Photons Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Retina Retinal Bipolar Cells - drug effects Retinal Bipolar Cells - metabolism SIGNALING Zinc
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