Disrupted fat absorption attenuates obesity induced by a high-fat diet in Clock mutant mice
The Clock gene is a core component of the circadian clock in mammals. We show here that serum levels of triglyceride and free fatty acid were significantly lower in circadian Clock mutant ICR than in wild-type control mice, whereas total cholesterol and glucose levels did not differ. Moreover, an in...
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| Veröffentlicht in: | FEBS letters 2006-01, Vol.580 (1), p.127-130 |
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| creator | Oishi, Katsutaka Atsumi, Gen-ichi Sugiyama, Shinobu Kodomari, Ikuko Kasamatsu, Manami Machida, Kazuhiko Ishida, Norio |
| description | The
Clock gene is a core component of the circadian clock in mammals. We show here that serum levels of triglyceride and free fatty acid were significantly lower in circadian
Clock mutant ICR than in wild-type control mice, whereas total cholesterol and glucose levels did not differ. Moreover, an increase in body weight induced by a high-fat diet was attenuated in homozygous
Clock mutant mice. We also found that dietary fat absorption was extremely impaired in
Clock mutant mice. Circadian expressions of cholecystokinin-A (CCK-A) receptor and lipase mRNAs were damped in the pancreas of
Clock mutant mice. We therefore showed that a
Clock mutation attenuates obesity induced by a high-fat diet in mice with an ICR background through impaired dietary fat absorption. Our results suggest that circadian clock molecules play an important role in lipid homeostasis in mammals. |
| doi_str_mv | 10.1016/j.febslet.2005.11.063 |
| format | Article |
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Clock gene is a core component of the circadian clock in mammals. We show here that serum levels of triglyceride and free fatty acid were significantly lower in circadian
Clock mutant ICR than in wild-type control mice, whereas total cholesterol and glucose levels did not differ. Moreover, an increase in body weight induced by a high-fat diet was attenuated in homozygous
Clock mutant mice. We also found that dietary fat absorption was extremely impaired in
Clock mutant mice. Circadian expressions of cholecystokinin-A (CCK-A) receptor and lipase mRNAs were damped in the pancreas of
Clock mutant mice. We therefore showed that a
Clock mutation attenuates obesity induced by a high-fat diet in mice with an ICR background through impaired dietary fat absorption. Our results suggest that circadian clock molecules play an important role in lipid homeostasis in mammals.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2005.11.063</identifier><identifier>PMID: 16343493</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Animals ; Cholecystokinin - biosynthesis ; Cholecystokinin-A receptor ; Circadian rhythm ; Circadian Rhythm - physiology ; Clock ; CLOCK Proteins ; Dietary Fats - administration & dosage ; Dietary Fats - metabolism ; Fatty Acids - blood ; Gene Expression Regulation - drug effects ; Gene Expression Regulation - genetics ; Homeostasis - genetics ; Lipid digestion ; Lipogenesis ; Mice ; Mice, Mutant Strains ; Obesity ; Obesity - blood ; Obesity - genetics ; Receptor, Cholecystokinin A - biosynthesis ; Trans-Activators - deficiency ; Trans-Activators - metabolism ; Triglycerides - blood</subject><ispartof>FEBS letters, 2006-01, Vol.580 (1), p.127-130</ispartof><rights>2005 Federation of European Biochemical Societies</rights><rights>FEBS Letters 580 (2006) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5411-795f50c2de6cb4c594baf4343f977233802ae79fcd574fa50d11817158d95a2e3</citedby><cites>FETCH-LOGICAL-c5411-795f50c2de6cb4c594baf4343f977233802ae79fcd574fa50d11817158d95a2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2005.11.063$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579305014341$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,1427,3537,27901,27902,45550,45551,46384,46808,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16343493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oishi, Katsutaka</creatorcontrib><creatorcontrib>Atsumi, Gen-ichi</creatorcontrib><creatorcontrib>Sugiyama, Shinobu</creatorcontrib><creatorcontrib>Kodomari, Ikuko</creatorcontrib><creatorcontrib>Kasamatsu, Manami</creatorcontrib><creatorcontrib>Machida, Kazuhiko</creatorcontrib><creatorcontrib>Ishida, Norio</creatorcontrib><title>Disrupted fat absorption attenuates obesity induced by a high-fat diet in Clock mutant mice</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The
Clock gene is a core component of the circadian clock in mammals. We show here that serum levels of triglyceride and free fatty acid were significantly lower in circadian
Clock mutant ICR than in wild-type control mice, whereas total cholesterol and glucose levels did not differ. Moreover, an increase in body weight induced by a high-fat diet was attenuated in homozygous
Clock mutant mice. We also found that dietary fat absorption was extremely impaired in
Clock mutant mice. Circadian expressions of cholecystokinin-A (CCK-A) receptor and lipase mRNAs were damped in the pancreas of
Clock mutant mice. We therefore showed that a
Clock mutation attenuates obesity induced by a high-fat diet in mice with an ICR background through impaired dietary fat absorption. Our results suggest that circadian clock molecules play an important role in lipid homeostasis in mammals.</description><subject>Animals</subject><subject>Cholecystokinin - biosynthesis</subject><subject>Cholecystokinin-A receptor</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - physiology</subject><subject>Clock</subject><subject>CLOCK Proteins</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fats - metabolism</subject><subject>Fatty Acids - blood</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gene Expression Regulation - genetics</subject><subject>Homeostasis - genetics</subject><subject>Lipid digestion</subject><subject>Lipogenesis</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - genetics</subject><subject>Receptor, Cholecystokinin A - biosynthesis</subject><subject>Trans-Activators - deficiency</subject><subject>Trans-Activators - metabolism</subject><subject>Triglycerides - blood</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv3CAUhVHVqJmk_QmNWHVnBwwYexWl07ykSFm0XXWBMFwaJn5MAaeafx-sGSnLZAWIc86997sIfaWkpITW55vSQRd7SGVFiCgpLUnNPqAVbSQrGK-bj2hFCOWFkC07Ricxbkh-N7T9hI5pzTjjLVuhPz98DPM2gcVOJ6y7OIVt8tOIdUowzjpBxFMH0acd9qOdTVZ2O6zxo__7WCwe6yHlL7zuJ_OEhznpMeHBG_iMjpzuI3w5nKfo9_XVr_Vtcf9wc7e-vC-M4JQWshVOEFNZqE3HjWh5p11uj7lWyoqxhlQaZOuMFZI7LYileQxJRWNboStgp-jbPncbpn8zxKQGHw30vR5hmqOqZZ0Hr3gWir3QhCnGAE5tgx902ClK1EJVbdSBqlqoKkpVppp9Z4cCczeAfXUdMGbB7V7w3_ewe1-qur76Xv1cVrRsiIh8YZzmqIt9FGRizx6CisbDmLH7ACYpO_k3un0BuC-gow</recordid><startdate>20060109</startdate><enddate>20060109</enddate><creator>Oishi, Katsutaka</creator><creator>Atsumi, Gen-ichi</creator><creator>Sugiyama, Shinobu</creator><creator>Kodomari, Ikuko</creator><creator>Kasamatsu, Manami</creator><creator>Machida, Kazuhiko</creator><creator>Ishida, Norio</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060109</creationdate><title>Disrupted fat absorption attenuates obesity induced by a high-fat diet in Clock mutant mice</title><author>Oishi, Katsutaka ; Atsumi, Gen-ichi ; Sugiyama, Shinobu ; Kodomari, Ikuko ; Kasamatsu, Manami ; Machida, Kazuhiko ; Ishida, Norio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5411-795f50c2de6cb4c594baf4343f977233802ae79fcd574fa50d11817158d95a2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Cholecystokinin - biosynthesis</topic><topic>Cholecystokinin-A receptor</topic><topic>Circadian rhythm</topic><topic>Circadian Rhythm - physiology</topic><topic>Clock</topic><topic>CLOCK Proteins</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fats - metabolism</topic><topic>Fatty Acids - blood</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Gene Expression Regulation - genetics</topic><topic>Homeostasis - genetics</topic><topic>Lipid digestion</topic><topic>Lipogenesis</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - genetics</topic><topic>Receptor, Cholecystokinin A - biosynthesis</topic><topic>Trans-Activators - deficiency</topic><topic>Trans-Activators - metabolism</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oishi, Katsutaka</creatorcontrib><creatorcontrib>Atsumi, Gen-ichi</creatorcontrib><creatorcontrib>Sugiyama, Shinobu</creatorcontrib><creatorcontrib>Kodomari, Ikuko</creatorcontrib><creatorcontrib>Kasamatsu, Manami</creatorcontrib><creatorcontrib>Machida, Kazuhiko</creatorcontrib><creatorcontrib>Ishida, Norio</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oishi, Katsutaka</au><au>Atsumi, Gen-ichi</au><au>Sugiyama, Shinobu</au><au>Kodomari, Ikuko</au><au>Kasamatsu, Manami</au><au>Machida, Kazuhiko</au><au>Ishida, Norio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disrupted fat absorption attenuates obesity induced by a high-fat diet in Clock mutant mice</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2006-01-09</date><risdate>2006</risdate><volume>580</volume><issue>1</issue><spage>127</spage><epage>130</epage><pages>127-130</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>The
Clock gene is a core component of the circadian clock in mammals. We show here that serum levels of triglyceride and free fatty acid were significantly lower in circadian
Clock mutant ICR than in wild-type control mice, whereas total cholesterol and glucose levels did not differ. Moreover, an increase in body weight induced by a high-fat diet was attenuated in homozygous
Clock mutant mice. We also found that dietary fat absorption was extremely impaired in
Clock mutant mice. Circadian expressions of cholecystokinin-A (CCK-A) receptor and lipase mRNAs were damped in the pancreas of
Clock mutant mice. We therefore showed that a
Clock mutation attenuates obesity induced by a high-fat diet in mice with an ICR background through impaired dietary fat absorption. Our results suggest that circadian clock molecules play an important role in lipid homeostasis in mammals.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>16343493</pmid><doi>10.1016/j.febslet.2005.11.063</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Animals Cholecystokinin - biosynthesis Cholecystokinin-A receptor Circadian rhythm Circadian Rhythm - physiology Clock CLOCK Proteins Dietary Fats - administration & dosage Dietary Fats - metabolism Fatty Acids - blood Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Homeostasis - genetics Lipid digestion Lipogenesis Mice Mice, Mutant Strains Obesity Obesity - blood Obesity - genetics Receptor, Cholecystokinin A - biosynthesis Trans-Activators - deficiency Trans-Activators - metabolism Triglycerides - blood |
| title | Disrupted fat absorption attenuates obesity induced by a high-fat diet in Clock mutant mice |
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