A Role for Lipid Bodies in the Cross-presentation of Phagocytosed Antigens by MHC Class I in Dendritic Cells

Dendritic cells (DCs) have the striking ability to cross-present exogenous antigens in association with major histocompatibility complex (MHC) class I to CD8+ T cells. However, the intracellular pathways underlying cross-presentation remain ill defined. Current models involve cytosolic proteolysis o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2009-08, Vol.31 (2), p.232-244
Hauptverfasser:	Bougnères, Laurence, Helft, Julie, Tiwari, Sangeeta, Vargas, Pablo, Chang, Benny Hung-Junn, Chan, Lawrence, Campisi, Laura, Lauvau, Gregoire, Hugues, Stephanie, Kumar, Pradeep, Kamphorst, Alice O., Dumenil, Ana-Maria Lennon, Nussenzweig, Michel, MacMicking, John D., Amigorena, Sebastian, Guermonprez, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation - immunology CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology CELLIMMUNO Cross-Priming Dendritic Cells - immunology Endoplasmic Reticulum - immunology Experiments GTP Phosphohydrolases - genetics GTP Phosphohydrolases - immunology GTP Phosphohydrolases - metabolism Histocompatibility Antigens Class I - immunology Lipids Lipids - immunology Membrane Proteins - genetics Membrane Proteins - immunology Membrane Proteins - metabolism Mice Mice, Knockout Mice, Transgenic MOLIMMUNO Peptides Perilipin-2 Phagocytosis Proteins
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!