Nonsynonymous single nucleotide polymorphisms in human tas1r1, tas1r3, and mGluR1 and individual taste sensitivity to glutamate

Several studies indicate an essential role of the heterodimer Tas1R1-Tas1R3 for monosodium L-glutamate (MSG) detection, although others suggest alternative receptors. Human subjects show different taste sensitivities to MSG, and some are unable to detect the presence of glutamate. Our objective was...

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Veröffentlicht in:	American Journal of Clinical Nutrition 2009-09, Vol.90 (3S), p.789S-799S
Hauptverfasser:	Raliou, Mariam, Wiencis, Anna, Pillias, Anne-Marie, Planchais, Aurore, Eloit, Corinne, Boucher, Yves, Trotier, Didier, Montmayeur, Jean-Pierre, Faurion, Annick
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Base Sequence Biological and medical sciences complementary DNA DNA fingerprinting Feeding. Feeding behavior Female Food and Nutrition France Fundamental and applied biological sciences. Psychology Gene Expression genes genetic variation Genomics Genotype Genotype & phenotype human physiology Humans immunohistochemistry Ions Life Sciences literature reviews Male molecular sequence data monosodium glutamate nucleotide sequences Phenotype phenotypic variation Polymorphism, Single Nucleotide - physiology Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Glutamate - genetics Receptors, Glutamate - metabolism Receptors, Metabotropic Glutamate - genetics Receptors, Metabotropic Glutamate - metabolism Reverse Transcriptase Polymerase Chain Reaction sensory receptors single nucleotide polymorphism Sodium Sodium Glutamate Taste Taste - genetics Taste - physiology Taste Buds taste sensitivity Taste Threshold - genetics Taste Threshold - physiology Transducin - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems
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