Correlation Between Angiotensin-converting Enzyme, Vascular Endothelial Growth Factor, and Matrix Metalloproteinase-9 in the Vitreous of Eyes With Diabetic Retinopathy
To investigate the involvement of angiotensin-converting enzyme (ACE) with angiogenic factors, vascular endothelial growth factor (VEGF), and matrix metalloproteinase (MMP)-9 in the vitreous of eyes with proliferative diabetic retinopathy (PDR). Observational case series. Angiotensin-conerting enzym...
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| Veröffentlicht in: | American journal of ophthalmology 2006, Vol.141 (1), p.129-134.e1 |
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| container_end_page | 134.e1 |
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| container_title | American journal of ophthalmology |
| container_volume | 141 |
| creator | Ishizaki, Eisuke Takai, Shinji Ueki, Mari Maeno, Takatoshi Maruichi, Midori Sugiyama, Tetsuya Oku, Hidehiro Ikeda, Tsunehiko Miyazaki, Mizuo |
| description | To investigate the involvement of angiotensin-converting enzyme (ACE) with angiogenic factors, vascular endothelial growth factor (VEGF), and matrix metalloproteinase (MMP)-9 in the vitreous of eyes with proliferative diabetic retinopathy (PDR).
Observational case series.
Angiotensin-conerting enzyme activity in the vitreous was measured by using a synthetic substrate for ACE. VEGF and MMP-9 concentrations were determined by enzyme-linked immunosorbent assay.
Vitreous ACE activity was significantly higher in eyes with PDR (1.4 ± 1.3 mU/ml) than in eyes with macular holes (0.22 ± 0.11 mU/ml). Vitreous VEGF concentration in the eyes with PDR (1067 ± 1076 pg/ml) was significantly higher than in eyes with macular holes (34 ± 5.5 pg/ml). Vitreous MMP-9 concentration was also significantly higher in eyes with PDR (7.5 ± 3.8 ng/ml) than in eyes with macular holes (4.2 ± 1.4 ng/ml). Significant correlations between ACE and VEGF (
P < .01) and between ACE and MMP-9 (
P < .01) were observed in the vitreous of eyes with PDR.
Angiotensin-converting enzyme was significantly correlated with angiogenic factors, VEGF and MMP-9, in the vitreous of eyes with PDR. |
| doi_str_mv | 10.1016/j.ajo.2005.08.066 |
| format | Article |
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Observational case series.
Angiotensin-conerting enzyme activity in the vitreous was measured by using a synthetic substrate for ACE. VEGF and MMP-9 concentrations were determined by enzyme-linked immunosorbent assay.
Vitreous ACE activity was significantly higher in eyes with PDR (1.4 ± 1.3 mU/ml) than in eyes with macular holes (0.22 ± 0.11 mU/ml). Vitreous VEGF concentration in the eyes with PDR (1067 ± 1076 pg/ml) was significantly higher than in eyes with macular holes (34 ± 5.5 pg/ml). Vitreous MMP-9 concentration was also significantly higher in eyes with PDR (7.5 ± 3.8 ng/ml) than in eyes with macular holes (4.2 ± 1.4 ng/ml). Significant correlations between ACE and VEGF (
P < .01) and between ACE and MMP-9 (
P < .01) were observed in the vitreous of eyes with PDR.
Angiotensin-converting enzyme was significantly correlated with angiogenic factors, VEGF and MMP-9, in the vitreous of eyes with PDR.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2005.08.066</identifier><identifier>PMID: 16386986</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>ACE inhibitors ; Aged ; Binding sites ; Biological and medical sciences ; Diabetes ; Diabetes. Impaired glucose tolerance ; Diabetic retinopathy ; Diabetic Retinopathy - enzymology ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Enzyme-Linked Immunosorbent Assay ; Enzymes ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Eyes & eyesight ; Female ; Humans ; Male ; Matrix Metalloproteinase 9 - blood ; Medical sciences ; Middle Aged ; Miscellaneous ; Ophthalmology ; Pathogenesis ; Patients ; Peptidyl-Dipeptidase A - blood ; Physiology ; Retinal Perforations - enzymology ; Retinopathies ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - blood ; Vitreous Body - enzymology</subject><ispartof>American journal of ophthalmology, 2006, Vol.141 (1), p.129-134.e1</ispartof><rights>2006 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jan 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c324t-6c55f28e13506903fe45baef2201f5b60fa36c05381306b19e891bae457eb86a3</citedby><cites>FETCH-LOGICAL-c324t-6c55f28e13506903fe45baef2201f5b60fa36c05381306b19e891bae457eb86a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajo.2005.08.066$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,4012,27910,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17440820$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16386986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishizaki, Eisuke</creatorcontrib><creatorcontrib>Takai, Shinji</creatorcontrib><creatorcontrib>Ueki, Mari</creatorcontrib><creatorcontrib>Maeno, Takatoshi</creatorcontrib><creatorcontrib>Maruichi, Midori</creatorcontrib><creatorcontrib>Sugiyama, Tetsuya</creatorcontrib><creatorcontrib>Oku, Hidehiro</creatorcontrib><creatorcontrib>Ikeda, Tsunehiko</creatorcontrib><creatorcontrib>Miyazaki, Mizuo</creatorcontrib><title>Correlation Between Angiotensin-converting Enzyme, Vascular Endothelial Growth Factor, and Matrix Metalloproteinase-9 in the Vitreous of Eyes With Diabetic Retinopathy</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>To investigate the involvement of angiotensin-converting enzyme (ACE) with angiogenic factors, vascular endothelial growth factor (VEGF), and matrix metalloproteinase (MMP)-9 in the vitreous of eyes with proliferative diabetic retinopathy (PDR).
Observational case series.
Angiotensin-conerting enzyme activity in the vitreous was measured by using a synthetic substrate for ACE. VEGF and MMP-9 concentrations were determined by enzyme-linked immunosorbent assay.
Vitreous ACE activity was significantly higher in eyes with PDR (1.4 ± 1.3 mU/ml) than in eyes with macular holes (0.22 ± 0.11 mU/ml). Vitreous VEGF concentration in the eyes with PDR (1067 ± 1076 pg/ml) was significantly higher than in eyes with macular holes (34 ± 5.5 pg/ml). Vitreous MMP-9 concentration was also significantly higher in eyes with PDR (7.5 ± 3.8 ng/ml) than in eyes with macular holes (4.2 ± 1.4 ng/ml). Significant correlations between ACE and VEGF (
P < .01) and between ACE and MMP-9 (
P < .01) were observed in the vitreous of eyes with PDR.
Angiotensin-converting enzyme was significantly correlated with angiogenic factors, VEGF and MMP-9, in the vitreous of eyes with PDR.</description><subject>ACE inhibitors</subject><subject>Aged</subject><subject>Binding sites</subject><subject>Biological and medical sciences</subject><subject>Diabetes</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic retinopathy</subject><subject>Diabetic Retinopathy - enzymology</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Enzymes</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Eyes & eyesight</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Matrix Metalloproteinase 9 - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Ophthalmology</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Peptidyl-Dipeptidase A - blood</subject><subject>Physiology</subject><subject>Retinal Perforations - enzymology</subject><subject>Retinopathies</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><subject>Vitreous Body - enzymology</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1rFDEUhgdR7Fr9Ad5IQPSqM57MRyaDV3XdVqFFEK2XIZM5082QTdYk07r-If-mWXah4IU3CQnPeXk5T5a9pFBQoOzdVMjJFSVAUwAvgLFH2YLytssp7-jjbAEAZd5VXX2SPQthSk_W1u3T7ISyirOOs0X2Z-m8RyOjdpZ8wHiPaMm5vdUuog3a5srZO_RR21uysr93GzwjNzKo2UifPgYX12i0NOTSu_u4JhdSRefPiLQDuZbR61_kGqM0xm19itRWBsw7oi1Jg-RGR49uDsSNZLXDQH7olPFRyx6jVuRrOq3byrjePc-ejNIEfHG8T7PvF6tvy0_51ZfLz8vzq1xVZR1zpppmLDnSqgHWQTVi3fQSx7IEOjY9g1FWTEFTcVoB62mHaVMJqJsWe85kdZq9PeSmuj9nDFFsdFBojLT7ooK1DIB3LIGv_wEnN3ubugnK6rorS1bViaIHSnkXgsdRbL3eSL8TFMTeoZhEcij2DgVwkRymmVfH5Lnf4PAwcZSWgDdHIImQZvTSKh0euLaugZeQuPcHDtPC7jR6EZRGq3DQHlUUg9P_qfEXzfa7kw</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Ishizaki, Eisuke</creator><creator>Takai, Shinji</creator><creator>Ueki, Mari</creator><creator>Maeno, Takatoshi</creator><creator>Maruichi, Midori</creator><creator>Sugiyama, Tetsuya</creator><creator>Oku, Hidehiro</creator><creator>Ikeda, Tsunehiko</creator><creator>Miyazaki, Mizuo</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Correlation Between Angiotensin-converting Enzyme, Vascular Endothelial Growth Factor, and Matrix Metalloproteinase-9 in the Vitreous of Eyes With Diabetic Retinopathy</title><author>Ishizaki, Eisuke ; Takai, Shinji ; Ueki, Mari ; Maeno, Takatoshi ; Maruichi, Midori ; Sugiyama, Tetsuya ; Oku, Hidehiro ; Ikeda, Tsunehiko ; Miyazaki, Mizuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-6c55f28e13506903fe45baef2201f5b60fa36c05381306b19e891bae457eb86a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>ACE inhibitors</topic><topic>Aged</topic><topic>Binding sites</topic><topic>Biological and medical sciences</topic><topic>Diabetes</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic retinopathy</topic><topic>Diabetic Retinopathy - enzymology</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Enzymes</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Eyes & eyesight</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Matrix Metalloproteinase 9 - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Ophthalmology</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Peptidyl-Dipeptidase A - blood</topic><topic>Physiology</topic><topic>Retinal Perforations - enzymology</topic><topic>Retinopathies</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><topic>Vitreous Body - enzymology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishizaki, Eisuke</creatorcontrib><creatorcontrib>Takai, Shinji</creatorcontrib><creatorcontrib>Ueki, Mari</creatorcontrib><creatorcontrib>Maeno, Takatoshi</creatorcontrib><creatorcontrib>Maruichi, Midori</creatorcontrib><creatorcontrib>Sugiyama, Tetsuya</creatorcontrib><creatorcontrib>Oku, Hidehiro</creatorcontrib><creatorcontrib>Ikeda, Tsunehiko</creatorcontrib><creatorcontrib>Miyazaki, Mizuo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishizaki, Eisuke</au><au>Takai, Shinji</au><au>Ueki, Mari</au><au>Maeno, Takatoshi</au><au>Maruichi, Midori</au><au>Sugiyama, Tetsuya</au><au>Oku, Hidehiro</au><au>Ikeda, Tsunehiko</au><au>Miyazaki, Mizuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation Between Angiotensin-converting Enzyme, Vascular Endothelial Growth Factor, and Matrix Metalloproteinase-9 in the Vitreous of Eyes With Diabetic Retinopathy</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2006</date><risdate>2006</risdate><volume>141</volume><issue>1</issue><spage>129</spage><epage>134.e1</epage><pages>129-134.e1</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>To investigate the involvement of angiotensin-converting enzyme (ACE) with angiogenic factors, vascular endothelial growth factor (VEGF), and matrix metalloproteinase (MMP)-9 in the vitreous of eyes with proliferative diabetic retinopathy (PDR).
Observational case series.
Angiotensin-conerting enzyme activity in the vitreous was measured by using a synthetic substrate for ACE. VEGF and MMP-9 concentrations were determined by enzyme-linked immunosorbent assay.
Vitreous ACE activity was significantly higher in eyes with PDR (1.4 ± 1.3 mU/ml) than in eyes with macular holes (0.22 ± 0.11 mU/ml). Vitreous VEGF concentration in the eyes with PDR (1067 ± 1076 pg/ml) was significantly higher than in eyes with macular holes (34 ± 5.5 pg/ml). Vitreous MMP-9 concentration was also significantly higher in eyes with PDR (7.5 ± 3.8 ng/ml) than in eyes with macular holes (4.2 ± 1.4 ng/ml). Significant correlations between ACE and VEGF (
P < .01) and between ACE and MMP-9 (
P < .01) were observed in the vitreous of eyes with PDR.
Angiotensin-converting enzyme was significantly correlated with angiogenic factors, VEGF and MMP-9, in the vitreous of eyes with PDR.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16386986</pmid><doi>10.1016/j.ajo.2005.08.066</doi><tpages>6</tpages></addata></record> |
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| ispartof | American journal of ophthalmology, 2006, Vol.141 (1), p.129-134.e1 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | ACE inhibitors Aged Binding sites Biological and medical sciences Diabetes Diabetes. Impaired glucose tolerance Diabetic retinopathy Diabetic Retinopathy - enzymology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme-Linked Immunosorbent Assay Enzymes Etiopathogenesis. Screening. Investigations. Target tissue resistance Eyes & eyesight Female Humans Male Matrix Metalloproteinase 9 - blood Medical sciences Middle Aged Miscellaneous Ophthalmology Pathogenesis Patients Peptidyl-Dipeptidase A - blood Physiology Retinal Perforations - enzymology Retinopathies Vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood Vitreous Body - enzymology |
| title | Correlation Between Angiotensin-converting Enzyme, Vascular Endothelial Growth Factor, and Matrix Metalloproteinase-9 in the Vitreous of Eyes With Diabetic Retinopathy |
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