A Randomized Study of Lung Cancer Screening with Spiral Computed Tomography: Three-year Results from the DANTE Trial
Screening for lung cancer with modern imaging technology may decrease lung cancer mortality, but encouraging results have only been obtained in uncontrolled studies. To explore the effect of screening with low-dose spiral computed tomography (LDCT) on lung cancer mortality. Secondary endpoints are i...
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| Veröffentlicht in: | American journal of respiratory and critical care medicine 2009-09, Vol.180 (5), p.445-453 |
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| creator | Infante, Maurizio Cavuto, Silvio Lutman, Fabio Romano Brambilla, Giorgio Chiesa, Giuseppe Ceresoli, Giovanni Passera, Eliseo Angeli, Enzo Chiarenza, Maurizio Aranzulla, Giuseppe Cariboni, Umberto Errico, Valentina Inzirillo, Francesco Bottoni, Edoardo Voulaz, Emanuele Alloisio, Marco Destro, Anna Roncalli, Massimo Santoro, Armando Ravasi, Gianluigi DANTE Study Group |
| description | Screening for lung cancer with modern imaging technology may decrease lung cancer mortality, but encouraging results have only been obtained in uncontrolled studies.
To explore the effect of screening with low-dose spiral computed tomography (LDCT) on lung cancer mortality. Secondary endpoints are incidence, stage at diagnosis, and resectability.
Male subjects, aged 60 to 75 years, smokers of 20 or more pack-years, were randomized to screening with LDCT or control groups. All participants underwent a baseline, once-only chest X-ray and sputum cytology examination. Screening-arm subjects had LDCT upon accrual to be repeated every year for 4 years, whereas controls had a yearly medical examination only.
A total of 2,811 subjects were randomized and 2,472 were enrolled (LDCT, 1,276; control, 1,196). After a median follow-up of 33 months, lung cancer was detected in 60 (4.7%) patients receiving LDCT and 34 (2.8%) control subjects (P = 0.016). Resectability rates were similar in both groups. More patients with stage I disease were detected by LDCT (54 vs. 34%; P = 0.06) and fewer cases were detected in the screening arm due to intercurrent symptoms. However, the number of advanced lung cancer cases was the same as in the control arm. Twenty patients in the LDCT group (1.6%) and 20 controls (1.7%) died of lung cancer, whereas 26 and 25 died of other causes, respectively.
The mortality benefit from lung cancer screening by LDCT might be far smaller than anticipated. |
| doi_str_mv | 10.1164/rccm.200901-0076OC |
| format | Article |
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To explore the effect of screening with low-dose spiral computed tomography (LDCT) on lung cancer mortality. Secondary endpoints are incidence, stage at diagnosis, and resectability.
Male subjects, aged 60 to 75 years, smokers of 20 or more pack-years, were randomized to screening with LDCT or control groups. All participants underwent a baseline, once-only chest X-ray and sputum cytology examination. Screening-arm subjects had LDCT upon accrual to be repeated every year for 4 years, whereas controls had a yearly medical examination only.
A total of 2,811 subjects were randomized and 2,472 were enrolled (LDCT, 1,276; control, 1,196). After a median follow-up of 33 months, lung cancer was detected in 60 (4.7%) patients receiving LDCT and 34 (2.8%) control subjects (P = 0.016). Resectability rates were similar in both groups. More patients with stage I disease were detected by LDCT (54 vs. 34%; P = 0.06) and fewer cases were detected in the screening arm due to intercurrent symptoms. However, the number of advanced lung cancer cases was the same as in the control arm. Twenty patients in the LDCT group (1.6%) and 20 controls (1.7%) died of lung cancer, whereas 26 and 25 died of other causes, respectively.
The mortality benefit from lung cancer screening by LDCT might be far smaller than anticipated.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/rccm.200901-0076OC</identifier><identifier>PMID: 19520905</identifier><language>eng</language><publisher>New York, NY: Am Thoracic Soc</publisher><subject>Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Cause of Death ; Clinical death. Palliative care. Organ gift and preservation ; Follow-Up Studies ; Humans ; Intensive care medicine ; Italy - epidemiology ; Lung cancer ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - mortality ; Male ; Mass Screening - methods ; Medical sciences ; Middle Aged ; Prospective Studies ; Radiography, Thoracic ; Survival Rate ; Tomography, Spiral Computed</subject><ispartof>American journal of respiratory and critical care medicine, 2009-09, Vol.180 (5), p.445-453</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright American Thoracic Society Sep 1, 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c343t-87cf68c726c86b87789132c0f8f634364ef5b7b5d87159e8fe021af88a1e640f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4011,4012,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21888461$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19520905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Infante, Maurizio</creatorcontrib><creatorcontrib>Cavuto, Silvio</creatorcontrib><creatorcontrib>Lutman, Fabio Romano</creatorcontrib><creatorcontrib>Brambilla, Giorgio</creatorcontrib><creatorcontrib>Chiesa, Giuseppe</creatorcontrib><creatorcontrib>Ceresoli, Giovanni</creatorcontrib><creatorcontrib>Passera, Eliseo</creatorcontrib><creatorcontrib>Angeli, Enzo</creatorcontrib><creatorcontrib>Chiarenza, Maurizio</creatorcontrib><creatorcontrib>Aranzulla, Giuseppe</creatorcontrib><creatorcontrib>Cariboni, Umberto</creatorcontrib><creatorcontrib>Errico, Valentina</creatorcontrib><creatorcontrib>Inzirillo, Francesco</creatorcontrib><creatorcontrib>Bottoni, Edoardo</creatorcontrib><creatorcontrib>Voulaz, Emanuele</creatorcontrib><creatorcontrib>Alloisio, Marco</creatorcontrib><creatorcontrib>Destro, Anna</creatorcontrib><creatorcontrib>Roncalli, Massimo</creatorcontrib><creatorcontrib>Santoro, Armando</creatorcontrib><creatorcontrib>Ravasi, Gianluigi</creatorcontrib><creatorcontrib>DANTE Study Group</creatorcontrib><creatorcontrib>DANTE Study Group</creatorcontrib><title>A Randomized Study of Lung Cancer Screening with Spiral Computed Tomography: Three-year Results from the DANTE Trial</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>Screening for lung cancer with modern imaging technology may decrease lung cancer mortality, but encouraging results have only been obtained in uncontrolled studies.
To explore the effect of screening with low-dose spiral computed tomography (LDCT) on lung cancer mortality. Secondary endpoints are incidence, stage at diagnosis, and resectability.
Male subjects, aged 60 to 75 years, smokers of 20 or more pack-years, were randomized to screening with LDCT or control groups. All participants underwent a baseline, once-only chest X-ray and sputum cytology examination. Screening-arm subjects had LDCT upon accrual to be repeated every year for 4 years, whereas controls had a yearly medical examination only.
A total of 2,811 subjects were randomized and 2,472 were enrolled (LDCT, 1,276; control, 1,196). After a median follow-up of 33 months, lung cancer was detected in 60 (4.7%) patients receiving LDCT and 34 (2.8%) control subjects (P = 0.016). Resectability rates were similar in both groups. More patients with stage I disease were detected by LDCT (54 vs. 34%; P = 0.06) and fewer cases were detected in the screening arm due to intercurrent symptoms. However, the number of advanced lung cancer cases was the same as in the control arm. Twenty patients in the LDCT group (1.6%) and 20 controls (1.7%) died of lung cancer, whereas 26 and 25 died of other causes, respectively.
The mortality benefit from lung cancer screening by LDCT might be far smaller than anticipated.</description><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Cause of Death</subject><subject>Clinical death. Palliative care. Organ gift and preservation</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Italy - epidemiology</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - mortality</subject><subject>Male</subject><subject>Mass Screening - methods</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Radiography, Thoracic</subject><subject>Survival Rate</subject><subject>Tomography, Spiral Computed</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0VuL1DAYBuAiinvQP-CFBEHBi65f2pzq3VDXAwwu7FTwLmQyyTRD23STlmX89Zuhg4JXCeF5v4S8WfYGww3GjHwKWvc3BUAFOAfg7K5-ll1iWtKcVByepz3wMiek-n2RXcV4AMCFwPAyu8AVLVKMXmbTCt2rYed798fs0Gaad0fkLVrPwx7VatAmoI0OxgwuHTy6qUWb0QXVodr34zylTON7vw9qbI-fUdMmmh-NCujexLmbIrLB92hqDfqy-tncoiY41b3KXljVRfP6vF5nv77eNvX3fH337Ue9Wue6JOWUC64tE5oXTAu2FZyLCpeFBissS4ARY-mWb-lOcEwrI6yBAisrhMKGEbDldfZhmTsG_zCbOMneRW26Tg3Gz1EyzgCYEAm--w8e_ByG9DaJq4oBqShLqFiQDj7GYKwcg-tVOEoM8lSIPBUil0LkUkgKvT1Pnre92f2LnBtI4P0ZqKhVZ0P6dBf_ugILIQjDyX1cXOv27aMLRsZedV0ai6U6nG7GAiSVhNDyCVRAoZ4</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Infante, Maurizio</creator><creator>Cavuto, Silvio</creator><creator>Lutman, Fabio Romano</creator><creator>Brambilla, Giorgio</creator><creator>Chiesa, Giuseppe</creator><creator>Ceresoli, Giovanni</creator><creator>Passera, Eliseo</creator><creator>Angeli, Enzo</creator><creator>Chiarenza, Maurizio</creator><creator>Aranzulla, Giuseppe</creator><creator>Cariboni, Umberto</creator><creator>Errico, Valentina</creator><creator>Inzirillo, Francesco</creator><creator>Bottoni, Edoardo</creator><creator>Voulaz, Emanuele</creator><creator>Alloisio, Marco</creator><creator>Destro, Anna</creator><creator>Roncalli, Massimo</creator><creator>Santoro, Armando</creator><creator>Ravasi, Gianluigi</creator><creator>DANTE Study Group</creator><general>Am Thoracic Soc</general><general>American Thoracic Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>A Randomized Study of Lung Cancer Screening with Spiral Computed Tomography: Three-year Results from the DANTE Trial</title><author>Infante, Maurizio ; Cavuto, Silvio ; Lutman, Fabio Romano ; Brambilla, Giorgio ; Chiesa, Giuseppe ; Ceresoli, Giovanni ; Passera, Eliseo ; Angeli, Enzo ; Chiarenza, Maurizio ; Aranzulla, Giuseppe ; Cariboni, Umberto ; Errico, Valentina ; Inzirillo, Francesco ; Bottoni, Edoardo ; Voulaz, Emanuele ; Alloisio, Marco ; Destro, Anna ; Roncalli, Massimo ; Santoro, Armando ; Ravasi, Gianluigi ; DANTE Study Group</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-87cf68c726c86b87789132c0f8f634364ef5b7b5d87159e8fe021af88a1e640f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Anesthesia. 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To explore the effect of screening with low-dose spiral computed tomography (LDCT) on lung cancer mortality. Secondary endpoints are incidence, stage at diagnosis, and resectability.
Male subjects, aged 60 to 75 years, smokers of 20 or more pack-years, were randomized to screening with LDCT or control groups. All participants underwent a baseline, once-only chest X-ray and sputum cytology examination. Screening-arm subjects had LDCT upon accrual to be repeated every year for 4 years, whereas controls had a yearly medical examination only.
A total of 2,811 subjects were randomized and 2,472 were enrolled (LDCT, 1,276; control, 1,196). After a median follow-up of 33 months, lung cancer was detected in 60 (4.7%) patients receiving LDCT and 34 (2.8%) control subjects (P = 0.016). Resectability rates were similar in both groups. More patients with stage I disease were detected by LDCT (54 vs. 34%; P = 0.06) and fewer cases were detected in the screening arm due to intercurrent symptoms. However, the number of advanced lung cancer cases was the same as in the control arm. Twenty patients in the LDCT group (1.6%) and 20 controls (1.7%) died of lung cancer, whereas 26 and 25 died of other causes, respectively.
The mortality benefit from lung cancer screening by LDCT might be far smaller than anticipated.</abstract><cop>New York, NY</cop><pub>Am Thoracic Soc</pub><pmid>19520905</pmid><doi>10.1164/rccm.200901-0076OC</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 1073-449X |
| ispartof | American journal of respiratory and critical care medicine, 2009-09, Vol.180 (5), p.445-453 |
| issn | 1073-449X 1535-4970 |
| language | eng |
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| source | MEDLINE; American Thoracic Society (ATS) Journals Online; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Cause of Death Clinical death. Palliative care. Organ gift and preservation Follow-Up Studies Humans Intensive care medicine Italy - epidemiology Lung cancer Lung Neoplasms - diagnostic imaging Lung Neoplasms - mortality Male Mass Screening - methods Medical sciences Middle Aged Prospective Studies Radiography, Thoracic Survival Rate Tomography, Spiral Computed |
| title | A Randomized Study of Lung Cancer Screening with Spiral Computed Tomography: Three-year Results from the DANTE Trial |
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