Activation of calpains, calpastatin and spectrin cleavage in the brain during the pathology of fatal murine cerebral malaria

Neuronal calpains appear to be activated uncontrollably by sustained elevation of cytosolic calcium levels under pathological conditions as well as neurodegenerative diseases. In the present study, we have characterized calpain activation in cytosolic extract of mice cerebral cortex and cerebellum u...

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Veröffentlicht in:	Neurochemistry international 2006, Vol.48 (2), p.108-113
Hauptverfasser:	Shukla, Meena, Rajgopal, Yadavalli, Babu, Phanithi Prakash
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Brain - enzymology Brain - metabolism Calcium-Binding Proteins - metabolism Calpain - metabolism Calpains Enzyme Activation Fatal murine cerebral malaria (FMCM) Female Fundamental and applied biological sciences. Psychology Hydrolysis Immunohistochemistry Malaria, Cerebral - enzymology Malaria, Cerebral - metabolism Malaria, Cerebral - pathology Male Mice Neurodegeneration Neurological sequelae Plasmodium berghei ANKA Spectrin Spectrin - metabolism Vertebrates: nervous system and sense organs
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