Regulation of matrix metalloproteinase-9 (MMP-9) in TNF-stimulated neutrophils: novel pathways for tertiary granule release

Matrix metalloproteinase‐9 (MMP‐9) is present in the tertiary granules of neutrophils and is rapidly released following stimulation. We examined the pathways that regulate tumor necrosis factor (TNF)‐mediated MMP‐9 release and found this to be dependent on the TNF receptor I. TNF rapidly activated e...

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Veröffentlicht in:	Journal of leukocyte biology 2006-01, Vol.79 (1), p.214-222
Hauptverfasser:	Chakrabarti, Subhadeep, Zee, Jennifer M., Patel, Kamala D.
Format:	Artikel
Sprache:	eng
Schlagworte:	CD18 Antigens - immunology Cell Degranulation - drug effects Cell Degranulation - immunology Cells, Cultured degranulation Enzyme Inhibitors - pharmacology Humans inflammation integrins MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - immunology Matrix Metalloproteinase 9 - secretion Neutrophil Activation - drug effects Neutrophil Activation - immunology Neutrophils - cytology Neutrophils - enzymology Neutrophils - immunology p38 Mitogen-Activated Protein Kinases - immunology protein kinase C Protein Kinase C - antagonists & inhibitors Protein Kinase C - immunology Protein Kinase C beta Protein Kinase C-alpha - antagonists & inhibitors Protein Kinase C-alpha - immunology Secretory Vesicles - enzymology signal transduction src-Family Kinases - immunology Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - pharmacology
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