Methods for structural characterization of prefibrillar intermediates and amyloid fibrils

Protein fibrillation is first and foremost a structural phenomenon. Adequate structural investigation of the central conformational individuals of the fibrillation process is however exceedingly difficult. This is due to the nature of the process, which may be described as a dynamically evolving equ...

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Veröffentlicht in:	FEBS letters 2009-08, Vol.583 (16), p.2600-2609
Hauptverfasser:	Langkilde, Annette Eva, Vestergaard, Bente
Format:	Artikel
Sprache:	eng
Schlagworte:	3-D AFM Amyloid Amyloid - chemistry amyloid β Animals atomic force microscopy circular dichroism electron microscopy ensemble optimization method EOM Fibril fourier-transform infrared spectroscopy FTIR Humans Models, Chemical Models, Molecular NMR nuclear magnetic resonance (spectroscopy) Protein Conformation Protein Structure, Secondary SANS SAS SAXS scaning tunneling electron microscopy Scattering, Small Angle Small angle X-ray scattering small-angle neutron scattering small-angle scattering solid-state NMR ss-NMR STEM Structure thioflavin T three dimensional ThT transthyretin TTR WAXS wide-angle X-ray scattering X-Ray Diffraction - methods
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