D85N, a KCNE1 Polymorphism, Is a Disease-Causing Gene Variant in Long QT Syndrome

Objectives This study aims to address whether D85N, a KCNE1 polymorphism, is a gene variant that causes long QT syndrome (LQTS) phenotype. Background KCNE1 encodes the beta-subunit of cardiac voltage-gated K+ channels and causes LQTS, which is characterized by the prolongation of the QT interval and...

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Veröffentlicht in:	Journal of the American College of Cardiology 2009-08, Vol.54 (9), p.812-819
Hauptverfasser:	Nishio, Yukiko, MD, Makiyama, Takeru, MD, PhD, Itoh, Hideki, MD, PhD, Sakaguchi, Tomoko, MD, PhD, Ohno, Seiko, MD, PhD, Gong, Yin-Zhi, MD, PhD, Yamamoto, Satoshi, MD, Ozawa, Tomoya, MD, PhD, Ding, Wei-Guang, MD, PhD, Toyoda, Futoshi, PhD, Kawamura, Mihoko, MD, Akao, Masaharu, MD, PhD, Matsuura, Hiroshi, MD, PhD, Kimura, Takeshi, MD, PhD, Kita, Toru, MD, PhD, Horie, Minoru, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Animals Cardiac arrhythmia Cardiology Cardiovascular Case-Control Studies Child Cricetinae disease-causing variant Electrocardiography Female Genes Humans Internal Medicine long QT syndrome Long QT Syndrome - genetics Male Middle Aged Mutation Polymorphism, Genetic Potassium Channels, Voltage-Gated - genetics single nucleotide polymorphism
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