Histopathology of anti-laminin 5 mucous membrane pemphigoid
Background Anti-laminin 5 mucous membrane pemphigoid (MMP) is an autoimmune blistering disease characterized by autoantibodies against the major basement membrane component laminin 5 (laminin 332, epiligrin). Objective and Methods We reviewed 17 biopsy specimens from 9 patients with anti-laminin 5 M...
Gespeichert in:
| Veröffentlicht in: | Journal of the American Academy of Dermatology 2009-09, Vol.61 (3), p.433-440 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 440 |
|---|---|
| container_issue | 3 |
| container_start_page | 433 |
| container_title | Journal of the American Academy of Dermatology |
| container_volume | 61 |
| creator | Rose, Christian, MD Schmidt, Enno, MD, PhD Kerstan, Andreas, MD Thoma-Uszynski, Sybille, MD Wesselmann, Ulrich, MD Käsbohrer, Ulrich, MD Zillikens, Detlef, MD Shimanovich, Iakov, MD |
| description | Background Anti-laminin 5 mucous membrane pemphigoid (MMP) is an autoimmune blistering disease characterized by autoantibodies against the major basement membrane component laminin 5 (laminin 332, epiligrin). Objective and Methods We reviewed 17 biopsy specimens from 9 patients with anti-laminin 5 MMP in an attempt to define typical histopathologic features of the disease. Results Fifteen specimens showed subepidermal blister formation, while two biopsy specimens revealed an epithelial ulcer. In 11 biopsies a sparse to moderate inflammatory infiltrate composed of lymphocytes and neutrophils with some eosinophils was observed. Four biopsies showed a dense infiltrate dominated by neutrophils in two cases and by eosinophils in one case. The remaining biopsy revealed a dense lymphoplasmacellular infiltrate without granulocytes. Scarring of the upper dermis was present only in 5 specimens. Immunohistochemical analysis localized type IV collagen to the dermal side of the blister, suggesting that split formation occurred within the lamina lucida of the cutaneous basement membrane. Limitations The number of patients studied was relatively small. Conclusions Histopathology of anti-laminin 5 MMP is characterized by subepidermal blistering and a sparse to moderate superficial lymphohistiocytic infiltrate with neutrophils and/or eosinophils. Both infiltrate density and composition may vary, making anti-laminin 5 MMP indistinguishable from other autoimmune subepidermal blistering diseases by histopathology alone. Scarring is present only in a minority of cases and is not a sensitive clue to the diagnosis of anti-laminin 5 MMP. |
| doi_str_mv | 10.1016/j.jaad.2009.02.012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67598541</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0190962209002400</els_id><sourcerecordid>67598541</sourcerecordid><originalsourceid>FETCH-LOGICAL-c505t-318d93c874010beb5c0422aab5071e12f70048bc45007acd836b0df32009ccb93</originalsourceid><addsrcrecordid>eNp9kc1q3TAQhUVpaW6SvkAWwZt2Z3ck_8iipVBCfgqBLpquhSyPE7m25Up24b59x9xLA11kJQTfGR19w9gFh4wDrz72WW9MmwkAlYHIgItXbMdBybSStXzNdsAVpKoS4oSdxtgDgUUu37ITriRdeL5jn-5cXPxslic_-Md94rvETItLBzO6yU1JmYyr9WtMRhybYCZMZhznJ_foXXvO3nRmiPjueJ6xnzfXD1d36f33229XX-9TW0K5pDmvW5XbWhbAocGmtFAIYUxTguTIRUddirqxRQkgjW3rvGqg7fLtX9Y2Kj9jHw5z5-B_rxgXPbpocRioDlXTlSxVXRacQHEAbfAxBuz0HNxowl5z0Jsy3etNmd5GaxCalFHo8jh9bUZsnyNHRwS8PwImWjN0ZMG6-I8TvJYV_ZG4zwcOycUfh0FH63Cy2LqAdtGtdy_3-PJf3A60AnrxF-4x9n4NE1nWXEcK6B_bcrfdggIQBUD-F5lgnRg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67598541</pqid></control><display><type>article</type><title>Histopathology of anti-laminin 5 mucous membrane pemphigoid</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Rose, Christian, MD ; Schmidt, Enno, MD, PhD ; Kerstan, Andreas, MD ; Thoma-Uszynski, Sybille, MD ; Wesselmann, Ulrich, MD ; Käsbohrer, Ulrich, MD ; Zillikens, Detlef, MD ; Shimanovich, Iakov, MD</creator><creatorcontrib>Rose, Christian, MD ; Schmidt, Enno, MD, PhD ; Kerstan, Andreas, MD ; Thoma-Uszynski, Sybille, MD ; Wesselmann, Ulrich, MD ; Käsbohrer, Ulrich, MD ; Zillikens, Detlef, MD ; Shimanovich, Iakov, MD</creatorcontrib><description>Background Anti-laminin 5 mucous membrane pemphigoid (MMP) is an autoimmune blistering disease characterized by autoantibodies against the major basement membrane component laminin 5 (laminin 332, epiligrin). Objective and Methods We reviewed 17 biopsy specimens from 9 patients with anti-laminin 5 MMP in an attempt to define typical histopathologic features of the disease. Results Fifteen specimens showed subepidermal blister formation, while two biopsy specimens revealed an epithelial ulcer. In 11 biopsies a sparse to moderate inflammatory infiltrate composed of lymphocytes and neutrophils with some eosinophils was observed. Four biopsies showed a dense infiltrate dominated by neutrophils in two cases and by eosinophils in one case. The remaining biopsy revealed a dense lymphoplasmacellular infiltrate without granulocytes. Scarring of the upper dermis was present only in 5 specimens. Immunohistochemical analysis localized type IV collagen to the dermal side of the blister, suggesting that split formation occurred within the lamina lucida of the cutaneous basement membrane. Limitations The number of patients studied was relatively small. Conclusions Histopathology of anti-laminin 5 MMP is characterized by subepidermal blistering and a sparse to moderate superficial lymphohistiocytic infiltrate with neutrophils and/or eosinophils. Both infiltrate density and composition may vary, making anti-laminin 5 MMP indistinguishable from other autoimmune subepidermal blistering diseases by histopathology alone. Scarring is present only in a minority of cases and is not a sensitive clue to the diagnosis of anti-laminin 5 MMP.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/j.jaad.2009.02.012</identifier><identifier>PMID: 19700013</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Autoantibodies - blood ; Basement Membrane - immunology ; Basement Membrane - pathology ; Biological and medical sciences ; Biopsy ; Bullous diseases of the skin ; Cell Adhesion Molecules - immunology ; Child ; Dermatology ; Female ; Fluorescent Antibody Technique, Direct ; Humans ; Immunoglobulin G - blood ; Kalinin ; Larynx - immunology ; Larynx - pathology ; Male ; Medical sciences ; Mouth - immunology ; Mouth - pathology ; Pemphigoid, Benign Mucous Membrane - immunology ; Pemphigoid, Benign Mucous Membrane - pathology ; Pharynx - immunology ; Pharynx - pathology ; Skin - immunology ; Skin - pathology ; Vulva - immunology ; Vulva - pathology</subject><ispartof>Journal of the American Academy of Dermatology, 2009-09, Vol.61 (3), p.433-440</ispartof><rights>American Academy of Dermatology, Inc.</rights><rights>2009 American Academy of Dermatology, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-318d93c874010beb5c0422aab5071e12f70048bc45007acd836b0df32009ccb93</citedby><cites>FETCH-LOGICAL-c505t-318d93c874010beb5c0422aab5071e12f70048bc45007acd836b0df32009ccb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0190962209002400$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21876318$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19700013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rose, Christian, MD</creatorcontrib><creatorcontrib>Schmidt, Enno, MD, PhD</creatorcontrib><creatorcontrib>Kerstan, Andreas, MD</creatorcontrib><creatorcontrib>Thoma-Uszynski, Sybille, MD</creatorcontrib><creatorcontrib>Wesselmann, Ulrich, MD</creatorcontrib><creatorcontrib>Käsbohrer, Ulrich, MD</creatorcontrib><creatorcontrib>Zillikens, Detlef, MD</creatorcontrib><creatorcontrib>Shimanovich, Iakov, MD</creatorcontrib><title>Histopathology of anti-laminin 5 mucous membrane pemphigoid</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Background Anti-laminin 5 mucous membrane pemphigoid (MMP) is an autoimmune blistering disease characterized by autoantibodies against the major basement membrane component laminin 5 (laminin 332, epiligrin). Objective and Methods We reviewed 17 biopsy specimens from 9 patients with anti-laminin 5 MMP in an attempt to define typical histopathologic features of the disease. Results Fifteen specimens showed subepidermal blister formation, while two biopsy specimens revealed an epithelial ulcer. In 11 biopsies a sparse to moderate inflammatory infiltrate composed of lymphocytes and neutrophils with some eosinophils was observed. Four biopsies showed a dense infiltrate dominated by neutrophils in two cases and by eosinophils in one case. The remaining biopsy revealed a dense lymphoplasmacellular infiltrate without granulocytes. Scarring of the upper dermis was present only in 5 specimens. Immunohistochemical analysis localized type IV collagen to the dermal side of the blister, suggesting that split formation occurred within the lamina lucida of the cutaneous basement membrane. Limitations The number of patients studied was relatively small. Conclusions Histopathology of anti-laminin 5 MMP is characterized by subepidermal blistering and a sparse to moderate superficial lymphohistiocytic infiltrate with neutrophils and/or eosinophils. Both infiltrate density and composition may vary, making anti-laminin 5 MMP indistinguishable from other autoimmune subepidermal blistering diseases by histopathology alone. Scarring is present only in a minority of cases and is not a sensitive clue to the diagnosis of anti-laminin 5 MMP.</description><subject>Adult</subject><subject>Aged</subject><subject>Autoantibodies - blood</subject><subject>Basement Membrane - immunology</subject><subject>Basement Membrane - pathology</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Bullous diseases of the skin</subject><subject>Cell Adhesion Molecules - immunology</subject><subject>Child</subject><subject>Dermatology</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Direct</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Kalinin</subject><subject>Larynx - immunology</subject><subject>Larynx - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mouth - immunology</subject><subject>Mouth - pathology</subject><subject>Pemphigoid, Benign Mucous Membrane - immunology</subject><subject>Pemphigoid, Benign Mucous Membrane - pathology</subject><subject>Pharynx - immunology</subject><subject>Pharynx - pathology</subject><subject>Skin - immunology</subject><subject>Skin - pathology</subject><subject>Vulva - immunology</subject><subject>Vulva - pathology</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1q3TAQhUVpaW6SvkAWwZt2Z3ck_8iipVBCfgqBLpquhSyPE7m25Up24b59x9xLA11kJQTfGR19w9gFh4wDrz72WW9MmwkAlYHIgItXbMdBybSStXzNdsAVpKoS4oSdxtgDgUUu37ITriRdeL5jn-5cXPxslic_-Md94rvETItLBzO6yU1JmYyr9WtMRhybYCZMZhznJ_foXXvO3nRmiPjueJ6xnzfXD1d36f33229XX-9TW0K5pDmvW5XbWhbAocGmtFAIYUxTguTIRUddirqxRQkgjW3rvGqg7fLtX9Y2Kj9jHw5z5-B_rxgXPbpocRioDlXTlSxVXRacQHEAbfAxBuz0HNxowl5z0Jsy3etNmd5GaxCalFHo8jh9bUZsnyNHRwS8PwImWjN0ZMG6-I8TvJYV_ZG4zwcOycUfh0FH63Cy2LqAdtGtdy_3-PJf3A60AnrxF-4x9n4NE1nWXEcK6B_bcrfdggIQBUD-F5lgnRg</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Rose, Christian, MD</creator><creator>Schmidt, Enno, MD, PhD</creator><creator>Kerstan, Andreas, MD</creator><creator>Thoma-Uszynski, Sybille, MD</creator><creator>Wesselmann, Ulrich, MD</creator><creator>Käsbohrer, Ulrich, MD</creator><creator>Zillikens, Detlef, MD</creator><creator>Shimanovich, Iakov, MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>Histopathology of anti-laminin 5 mucous membrane pemphigoid</title><author>Rose, Christian, MD ; Schmidt, Enno, MD, PhD ; Kerstan, Andreas, MD ; Thoma-Uszynski, Sybille, MD ; Wesselmann, Ulrich, MD ; Käsbohrer, Ulrich, MD ; Zillikens, Detlef, MD ; Shimanovich, Iakov, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-318d93c874010beb5c0422aab5071e12f70048bc45007acd836b0df32009ccb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Autoantibodies - blood</topic><topic>Basement Membrane - immunology</topic><topic>Basement Membrane - pathology</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Bullous diseases of the skin</topic><topic>Cell Adhesion Molecules - immunology</topic><topic>Child</topic><topic>Dermatology</topic><topic>Female</topic><topic>Fluorescent Antibody Technique, Direct</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Kalinin</topic><topic>Larynx - immunology</topic><topic>Larynx - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mouth - immunology</topic><topic>Mouth - pathology</topic><topic>Pemphigoid, Benign Mucous Membrane - immunology</topic><topic>Pemphigoid, Benign Mucous Membrane - pathology</topic><topic>Pharynx - immunology</topic><topic>Pharynx - pathology</topic><topic>Skin - immunology</topic><topic>Skin - pathology</topic><topic>Vulva - immunology</topic><topic>Vulva - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rose, Christian, MD</creatorcontrib><creatorcontrib>Schmidt, Enno, MD, PhD</creatorcontrib><creatorcontrib>Kerstan, Andreas, MD</creatorcontrib><creatorcontrib>Thoma-Uszynski, Sybille, MD</creatorcontrib><creatorcontrib>Wesselmann, Ulrich, MD</creatorcontrib><creatorcontrib>Käsbohrer, Ulrich, MD</creatorcontrib><creatorcontrib>Zillikens, Detlef, MD</creatorcontrib><creatorcontrib>Shimanovich, Iakov, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rose, Christian, MD</au><au>Schmidt, Enno, MD, PhD</au><au>Kerstan, Andreas, MD</au><au>Thoma-Uszynski, Sybille, MD</au><au>Wesselmann, Ulrich, MD</au><au>Käsbohrer, Ulrich, MD</au><au>Zillikens, Detlef, MD</au><au>Shimanovich, Iakov, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histopathology of anti-laminin 5 mucous membrane pemphigoid</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>61</volume><issue>3</issue><spage>433</spage><epage>440</epage><pages>433-440</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>Background Anti-laminin 5 mucous membrane pemphigoid (MMP) is an autoimmune blistering disease characterized by autoantibodies against the major basement membrane component laminin 5 (laminin 332, epiligrin). Objective and Methods We reviewed 17 biopsy specimens from 9 patients with anti-laminin 5 MMP in an attempt to define typical histopathologic features of the disease. Results Fifteen specimens showed subepidermal blister formation, while two biopsy specimens revealed an epithelial ulcer. In 11 biopsies a sparse to moderate inflammatory infiltrate composed of lymphocytes and neutrophils with some eosinophils was observed. Four biopsies showed a dense infiltrate dominated by neutrophils in two cases and by eosinophils in one case. The remaining biopsy revealed a dense lymphoplasmacellular infiltrate without granulocytes. Scarring of the upper dermis was present only in 5 specimens. Immunohistochemical analysis localized type IV collagen to the dermal side of the blister, suggesting that split formation occurred within the lamina lucida of the cutaneous basement membrane. Limitations The number of patients studied was relatively small. Conclusions Histopathology of anti-laminin 5 MMP is characterized by subepidermal blistering and a sparse to moderate superficial lymphohistiocytic infiltrate with neutrophils and/or eosinophils. Both infiltrate density and composition may vary, making anti-laminin 5 MMP indistinguishable from other autoimmune subepidermal blistering diseases by histopathology alone. Scarring is present only in a minority of cases and is not a sensitive clue to the diagnosis of anti-laminin 5 MMP.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>19700013</pmid><doi>10.1016/j.jaad.2009.02.012</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0190-9622 |
| ispartof | Journal of the American Academy of Dermatology, 2009-09, Vol.61 (3), p.433-440 |
| issn | 0190-9622 1097-6787 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67598541 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Autoantibodies - blood Basement Membrane - immunology Basement Membrane - pathology Biological and medical sciences Biopsy Bullous diseases of the skin Cell Adhesion Molecules - immunology Child Dermatology Female Fluorescent Antibody Technique, Direct Humans Immunoglobulin G - blood Kalinin Larynx - immunology Larynx - pathology Male Medical sciences Mouth - immunology Mouth - pathology Pemphigoid, Benign Mucous Membrane - immunology Pemphigoid, Benign Mucous Membrane - pathology Pharynx - immunology Pharynx - pathology Skin - immunology Skin - pathology Vulva - immunology Vulva - pathology |
| title | Histopathology of anti-laminin 5 mucous membrane pemphigoid |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T13%3A18%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Histopathology%20of%20anti-laminin%205%20mucous%20membrane%20pemphigoid&rft.jtitle=Journal%20of%20the%20American%20Academy%20of%20Dermatology&rft.au=Rose,%20Christian,%20MD&rft.date=2009-09-01&rft.volume=61&rft.issue=3&rft.spage=433&rft.epage=440&rft.pages=433-440&rft.issn=0190-9622&rft.eissn=1097-6787&rft.coden=JAADDB&rft_id=info:doi/10.1016/j.jaad.2009.02.012&rft_dat=%3Cproquest_cross%3E67598541%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67598541&rft_id=info:pmid/19700013&rft_els_id=1_s2_0_S0190962209002400&rfr_iscdi=true |