Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality

By comparing mammalian genomes, we and others have identified actively transcribed Ty3/gypsy retrotransposon-derived genes with highly conserved DNA sequences and insertion sites 1 , 2 , 3 , 4 , 5 , 6 . To elucidate the functions of evolutionarily conserved retrotransposon-derived genes in mammalian...

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Veröffentlicht in:	Nature genetics 2006-01, Vol.38 (1), p.101-106
Hauptverfasser:	Ono, Ryuichi, Nakamura, Kenji, Inoue, Kimiko, Naruse, Mie, Usami, Takako, Wakisaka-Saito, Noriko, Hino, Toshiaki, Suzuki-Migishima, Rika, Ogonuki, Narumi, Miki, Hiromi, Kohda, Takashi, Ogura, Atsuo, Yokoyama, Minesuke, Kaneko-Ishino, Tomoko, Ishino, Fumitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Chromosome aberrations Complications and side effects Deoxyribonucleic acid DNA DNA Methylation Embryo Loss - genetics Female Fetal Growth Retardation - genetics Fundamental and applied biological sciences. Psychology Gene Deletion Gene Expression Regulation, Developmental Gene Function Gene mutations Genetics of eukaryotes. Biological and molecular evolution Genic rearrangement. Recombination. Transposable element Genomic Imprinting Human Genetics letter Mammals Medical genetics Medical sciences Mice Mice, Knockout Molecular and cellular biology Molecular genetics Nuclear Proteins - genetics Nuclear Proteins - metabolism Parthenogenesis - genetics Physiological aspects Placenta - pathology Placenta - physiology Pregnancy Retroelements Retrotransposons Transcription Factors - genetics Transcription Factors - metabolism
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