Hypothermia during reperfusion does not reduce myocardial infarct size in pigs
We previously described a method for regional myocardial cooling that reaches the target temperature within 4 min. The present study evaluated whether this method for regional myocardial cooling during reperfusion reduces myocardial infarct size (IS) in 75-kg pigs. Myocardial infarction was induced...
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| Veröffentlicht in: | Basic research in cardiology 2006-01, Vol.101 (1), p.61-68 |
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| creator | Maeng, Michael Mortensen, Ulrik M Kristensen, Jens Kristiansen, Steen B Andersen, Henning R |
| description | We previously described a method for regional myocardial cooling that reaches the target temperature within 4 min. The present study evaluated whether this method for regional myocardial cooling during reperfusion reduces myocardial infarct size (IS) in 75-kg pigs. Myocardial infarction was induced by inflation of an angioplasty balloon in the left anterior descendent artery for 45 min followed by 3 h reperfusion. First, 15 pigs were randomized to regional myocardial cooling during reperfusion (n = 8) or control (n = 7). As further control experiments, systemic hypothermia was induced prior to ischemia (n = 3) and during reperfusion (n = 3). IS and area at risk (AAR) were evaluated in vivo by single photon emission cardiac tomography (SPECT) and by standard histochemical staining. Regional cooling during reperfusion did not reduce IS/AAR as assessed by histochemistry (cooling: 0.71 +/- 0.8; control: 0.68 +/- 0.10; p = ns) and SPECT (cooling: 0.90 +/- 0.20; control: 0.88 +/- 0.32; p = ns). Systemic hypothermia during ischemia reduced IS/AAR (histochemistry: 0.09 +/- 0.11; SPECT: 0.25 +/- 0.22; p < 0.001 and p = 0.01 vs control, respectively). Induction of systemic hypothermia during reperfusion had no significant effect on IS/AAR (histochemistry: 0.63 +/- 0.07; SPECT: 0.74 +/- 0.09; p = ns vs control for both comparisons). In conclusion, hypothermia during ischemia is strongly myocardioprotective while hypothermia during reperfusion does not reduce myocardial infarct size in human-sized pigs. |
| doi_str_mv | 10.1007/s00395-005-0550-7 |
| format | Article |
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The present study evaluated whether this method for regional myocardial cooling during reperfusion reduces myocardial infarct size (IS) in 75-kg pigs. Myocardial infarction was induced by inflation of an angioplasty balloon in the left anterior descendent artery for 45 min followed by 3 h reperfusion. First, 15 pigs were randomized to regional myocardial cooling during reperfusion (n = 8) or control (n = 7). As further control experiments, systemic hypothermia was induced prior to ischemia (n = 3) and during reperfusion (n = 3). IS and area at risk (AAR) were evaluated in vivo by single photon emission cardiac tomography (SPECT) and by standard histochemical staining. Regional cooling during reperfusion did not reduce IS/AAR as assessed by histochemistry (cooling: 0.71 +/- 0.8; control: 0.68 +/- 0.10; p = ns) and SPECT (cooling: 0.90 +/- 0.20; control: 0.88 +/- 0.32; p = ns). Systemic hypothermia during ischemia reduced IS/AAR (histochemistry: 0.09 +/- 0.11; SPECT: 0.25 +/- 0.22; p < 0.001 and p = 0.01 vs control, respectively). Induction of systemic hypothermia during reperfusion had no significant effect on IS/AAR (histochemistry: 0.63 +/- 0.07; SPECT: 0.74 +/- 0.09; p = ns vs control for both comparisons). In conclusion, hypothermia during ischemia is strongly myocardioprotective while hypothermia during reperfusion does not reduce myocardial infarct size in human-sized pigs.</description><identifier>ISSN: 0300-8428</identifier><identifier>EISSN: 1435-1803</identifier><identifier>DOI: 10.1007/s00395-005-0550-7</identifier><identifier>PMID: 16177842</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Animals ; Blood Pressure ; Body Temperature ; Heart Rate ; Hypothermia, Induced ; Myocardial Infarction - pathology ; Myocardial Infarction - therapy ; Myocardial Reperfusion - methods ; Myocardium - pathology ; Swine ; Time Factors ; Ventricular Fibrillation</subject><ispartof>Basic research in cardiology, 2006-01, Vol.101 (1), p.61-68</ispartof><rights>Steinkopff-Verlag 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-b97685bf99398f73074d2515bef3788a4189bb3a01186b43686923fd6d8d874f3</citedby><cites>FETCH-LOGICAL-c326t-b97685bf99398f73074d2515bef3788a4189bb3a01186b43686923fd6d8d874f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16177842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maeng, Michael</creatorcontrib><creatorcontrib>Mortensen, Ulrik M</creatorcontrib><creatorcontrib>Kristensen, Jens</creatorcontrib><creatorcontrib>Kristiansen, Steen B</creatorcontrib><creatorcontrib>Andersen, Henning R</creatorcontrib><title>Hypothermia during reperfusion does not reduce myocardial infarct size in pigs</title><title>Basic research in cardiology</title><addtitle>Basic Res Cardiol</addtitle><description>We previously described a method for regional myocardial cooling that reaches the target temperature within 4 min. The present study evaluated whether this method for regional myocardial cooling during reperfusion reduces myocardial infarct size (IS) in 75-kg pigs. Myocardial infarction was induced by inflation of an angioplasty balloon in the left anterior descendent artery for 45 min followed by 3 h reperfusion. First, 15 pigs were randomized to regional myocardial cooling during reperfusion (n = 8) or control (n = 7). As further control experiments, systemic hypothermia was induced prior to ischemia (n = 3) and during reperfusion (n = 3). IS and area at risk (AAR) were evaluated in vivo by single photon emission cardiac tomography (SPECT) and by standard histochemical staining. Regional cooling during reperfusion did not reduce IS/AAR as assessed by histochemistry (cooling: 0.71 +/- 0.8; control: 0.68 +/- 0.10; p = ns) and SPECT (cooling: 0.90 +/- 0.20; control: 0.88 +/- 0.32; p = ns). Systemic hypothermia during ischemia reduced IS/AAR (histochemistry: 0.09 +/- 0.11; SPECT: 0.25 +/- 0.22; p < 0.001 and p = 0.01 vs control, respectively). Induction of systemic hypothermia during reperfusion had no significant effect on IS/AAR (histochemistry: 0.63 +/- 0.07; SPECT: 0.74 +/- 0.09; p = ns vs control for both comparisons). In conclusion, hypothermia during ischemia is strongly myocardioprotective while hypothermia during reperfusion does not reduce myocardial infarct size in human-sized pigs.</description><subject>Animals</subject><subject>Blood Pressure</subject><subject>Body Temperature</subject><subject>Heart Rate</subject><subject>Hypothermia, Induced</subject><subject>Myocardial Infarction - pathology</subject><subject>Myocardial Infarction - therapy</subject><subject>Myocardial Reperfusion - methods</subject><subject>Myocardium - pathology</subject><subject>Swine</subject><subject>Time Factors</subject><subject>Ventricular Fibrillation</subject><issn>0300-8428</issn><issn>1435-1803</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkE9r3DAQxUVpaDbbfoBeiumhNyczlvXvWJa2G1iSS3oWsiVtFdaWK9mHzaePll0I5DAMM_PeY_gR8hXhFgHEXQagitUApRiDWnwgK2wpq1EC_UhWQAFq2Tbymtzk_AyALef4iVwjRyHKYUUetscpzv9cGoKp7JLCuK-Sm1zySw5xrGx0uRrjXJZ26V01HGNvkg3mUIXRm9TPVQ4vrgzVFPb5M7ny5pDdl0tfk7-_fz1ttvXu8c_95ueu7mnD57pTgkvWeaWokl5QEK1tGLLOeSqkNC1K1XXUAKLkXUu55Kqh3nIrrRStp2vy45w7pfh_cXnWQ8i9OxzM6OKSNRdMcYVNEX5_J3yOSxrLb7pBCkiRqSLCs6hPMefkvJ5SGEw6agR9Iq3PpHUhrU-ktSieb5fgpRucfXNc0NJXFU54Dw</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Maeng, Michael</creator><creator>Mortensen, Ulrik M</creator><creator>Kristensen, Jens</creator><creator>Kristiansen, Steen B</creator><creator>Andersen, Henning R</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200601</creationdate><title>Hypothermia during reperfusion does not reduce myocardial infarct size in pigs</title><author>Maeng, Michael ; Mortensen, Ulrik M ; Kristensen, Jens ; Kristiansen, Steen B ; Andersen, Henning R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-b97685bf99398f73074d2515bef3788a4189bb3a01186b43686923fd6d8d874f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Blood Pressure</topic><topic>Body Temperature</topic><topic>Heart Rate</topic><topic>Hypothermia, Induced</topic><topic>Myocardial Infarction - pathology</topic><topic>Myocardial Infarction - therapy</topic><topic>Myocardial Reperfusion - methods</topic><topic>Myocardium - pathology</topic><topic>Swine</topic><topic>Time Factors</topic><topic>Ventricular Fibrillation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maeng, Michael</creatorcontrib><creatorcontrib>Mortensen, Ulrik M</creatorcontrib><creatorcontrib>Kristensen, Jens</creatorcontrib><creatorcontrib>Kristiansen, Steen B</creatorcontrib><creatorcontrib>Andersen, Henning R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Basic research in cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maeng, Michael</au><au>Mortensen, Ulrik M</au><au>Kristensen, Jens</au><au>Kristiansen, Steen B</au><au>Andersen, Henning R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypothermia during reperfusion does not reduce myocardial infarct size in pigs</atitle><jtitle>Basic research in cardiology</jtitle><addtitle>Basic Res Cardiol</addtitle><date>2006-01</date><risdate>2006</risdate><volume>101</volume><issue>1</issue><spage>61</spage><epage>68</epage><pages>61-68</pages><issn>0300-8428</issn><eissn>1435-1803</eissn><abstract>We previously described a method for regional myocardial cooling that reaches the target temperature within 4 min. The present study evaluated whether this method for regional myocardial cooling during reperfusion reduces myocardial infarct size (IS) in 75-kg pigs. Myocardial infarction was induced by inflation of an angioplasty balloon in the left anterior descendent artery for 45 min followed by 3 h reperfusion. First, 15 pigs were randomized to regional myocardial cooling during reperfusion (n = 8) or control (n = 7). As further control experiments, systemic hypothermia was induced prior to ischemia (n = 3) and during reperfusion (n = 3). IS and area at risk (AAR) were evaluated in vivo by single photon emission cardiac tomography (SPECT) and by standard histochemical staining. Regional cooling during reperfusion did not reduce IS/AAR as assessed by histochemistry (cooling: 0.71 +/- 0.8; control: 0.68 +/- 0.10; p = ns) and SPECT (cooling: 0.90 +/- 0.20; control: 0.88 +/- 0.32; p = ns). Systemic hypothermia during ischemia reduced IS/AAR (histochemistry: 0.09 +/- 0.11; SPECT: 0.25 +/- 0.22; p < 0.001 and p = 0.01 vs control, respectively). Induction of systemic hypothermia during reperfusion had no significant effect on IS/AAR (histochemistry: 0.63 +/- 0.07; SPECT: 0.74 +/- 0.09; p = ns vs control for both comparisons). In conclusion, hypothermia during ischemia is strongly myocardioprotective while hypothermia during reperfusion does not reduce myocardial infarct size in human-sized pigs.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>16177842</pmid><doi>10.1007/s00395-005-0550-7</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Blood Pressure Body Temperature Heart Rate Hypothermia, Induced Myocardial Infarction - pathology Myocardial Infarction - therapy Myocardial Reperfusion - methods Myocardium - pathology Swine Time Factors Ventricular Fibrillation |
| title | Hypothermia during reperfusion does not reduce myocardial infarct size in pigs |
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