No evidence of a significant role for CTLA-4 in multiple sclerosis

Variation in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene plays a significant role in determining susceptibility to autoimmune thyroid disease and type 1 diabetes. Its role in multiple sclerosis is more controversial. In order to explore this logical candidate more thoroughly, we ge...

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Veröffentlicht in:	Journal of neuroimmunology 2006-02, Vol.171 (1), p.193-197
Hauptverfasser:	Roxburgh, Richard H., Sawcer, Stephen, Maranian, Mel, Seaman, Shaun, Hensiek, Anke, Yeo, Taiwai, Deans, Jackie, Compston, Alastair
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - physiology Adult Antigens, CD Antigens, Differentiation - genetics Chi-Square Distribution CTLA-4 CTLA-4 Antigen Cytotoxic T-lymphocyte-associated protein 4 Disease severity Female Genetic association Genetic Predisposition to Disease Genotype Humans Male Minisatellite Repeats - genetics Multiple sclerosis Multiple Sclerosis - epidemiology Multiple Sclerosis - genetics Polymorphism, Genetic - genetics
Online-Zugang:	Volltext
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