No evidence of a significant role for CTLA-4 in multiple sclerosis
Variation in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene plays a significant role in determining susceptibility to autoimmune thyroid disease and type 1 diabetes. Its role in multiple sclerosis is more controversial. In order to explore this logical candidate more thoroughly, we ge...
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| Veröffentlicht in: | Journal of neuroimmunology 2006-02, Vol.171 (1), p.193-197 |
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| container_title | Journal of neuroimmunology |
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| creator | Roxburgh, Richard H. Sawcer, Stephen Maranian, Mel Seaman, Shaun Hensiek, Anke Yeo, Taiwai Deans, Jackie Compston, Alastair |
| description | Variation in the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) gene plays a significant role in determining susceptibility to autoimmune thyroid disease and type 1 diabetes. Its role in multiple sclerosis is more controversial. In order to explore this logical candidate more thoroughly, we genotyped 771 multiple sclerosis trio families from the United Kingdom for the 3′ untranslated region variable number tandem repeat, the CT60 single nucleotide polymorphism (SNP) and five haplotype-tagging SNPs. No individual marker or common haplotype showed evidence of association with disease. These data suggest that any effect of CTLA-4 on multiple sclerosis susceptibility is likely to be very small. |
| doi_str_mv | 10.1016/j.jneuroim.2005.10.006 |
| format | Article |
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Its role in multiple sclerosis is more controversial. In order to explore this logical candidate more thoroughly, we genotyped 771 multiple sclerosis trio families from the United Kingdom for the 3′ untranslated region variable number tandem repeat, the CT60 single nucleotide polymorphism (SNP) and five haplotype-tagging SNPs. No individual marker or common haplotype showed evidence of association with disease. These data suggest that any effect of CTLA-4 on multiple sclerosis susceptibility is likely to be very small.</description><subject>3' Untranslated Regions - physiology</subject><subject>Adult</subject><subject>Antigens, CD</subject><subject>Antigens, Differentiation - genetics</subject><subject>Chi-Square Distribution</subject><subject>CTLA-4</subject><subject>CTLA-4 Antigen</subject><subject>Cytotoxic T-lymphocyte-associated protein 4</subject><subject>Disease severity</subject><subject>Female</subject><subject>Genetic association</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Minisatellite Repeats - genetics</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - epidemiology</subject><subject>Multiple Sclerosis - genetics</subject><subject>Polymorphism, Genetic - genetics</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMGK2zAQhkXp0mTTvkLQqTdnNbIkS7emod0thO4ld2HL40XBtrKSHejbVyEpPeY08PP9M8xHyBrYBhiop-PmOOIcgx82nDGZww1j6gNZgq54oQWHj2SZQVnIiusFeUzpyBjIUphPZAGq5JJX5ZJ8_x0onn2Lo0MaOlrT5N9G33lXjxONoUfahUh3h_22ENSPdJj7yZ9ynFyPMSSfPpOHru4TfrnNFTn8_HHYvRT71-dfu-2-cELIqaiY0twY1IJxaBqQdVPWjWiNbgUTjQOlOIjOCa2ZQ2FcI7UxpTKc1RLKckW-XteeYnifMU128Mlh39cjhjlZVUmjGFR3QaiY5sAhg-oKuvxHitjZU_RDHf9YYPZi2R7tP8v2YvmSZ8u5uL5dmJsB2_-1m9YMfLsCmH2cPUabnL8obn1EN9k2-Hs3_gKcRo8I</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Roxburgh, Richard H.</creator><creator>Sawcer, Stephen</creator><creator>Maranian, Mel</creator><creator>Seaman, Shaun</creator><creator>Hensiek, Anke</creator><creator>Yeo, Taiwai</creator><creator>Deans, Jackie</creator><creator>Compston, Alastair</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>No evidence of a significant role for CTLA-4 in multiple sclerosis</title><author>Roxburgh, Richard H. ; 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| identifier | ISSN: 0165-5728 |
| ispartof | Journal of neuroimmunology, 2006-02, Vol.171 (1), p.193-197 |
| issn | 0165-5728 1872-8421 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 3' Untranslated Regions - physiology Adult Antigens, CD Antigens, Differentiation - genetics Chi-Square Distribution CTLA-4 CTLA-4 Antigen Cytotoxic T-lymphocyte-associated protein 4 Disease severity Female Genetic association Genetic Predisposition to Disease Genotype Humans Male Minisatellite Repeats - genetics Multiple sclerosis Multiple Sclerosis - epidemiology Multiple Sclerosis - genetics Polymorphism, Genetic - genetics |
| title | No evidence of a significant role for CTLA-4 in multiple sclerosis |
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