The Gli3 Transcription Factor Expressed in the Thymus Stroma Controls Thymocyte Negative Selection Via Hedgehog-Dependent and -Independent Mechanisms

The Hedgehog (Hh) responsive transcription factor Gli3 is required for efficient thymocyte development in the fetus. In this study we show that Gli3, not detected in adult thymocytes, is expressed in the murine fetal and adult thymus stroma. PCR array analysis revealed Cxcl9, Rbp1, and Nos2 as novel...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-09, Vol.183 (5), p.3023-3032
Hauptverfasser:	Hager-Theodorides, Ariadne L, Furmanski, Anna L, Ross, Susan E, Outram, Susan V, Rowbotham, Nicola J, Crompton, Tessa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Cell Differentiation - genetics Cell Differentiation - immunology Female Gene Expression Regulation, Developmental - immunology Growth Inhibitors - biosynthesis Growth Inhibitors - genetics Growth Inhibitors - physiology Hedgehog Proteins - physiology Kruppel-Like Transcription Factors - biosynthesis Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - physiology Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Organ Culture Techniques Receptors, Antigen, T-Cell - biosynthesis Receptors, Antigen, T-Cell - physiology Stromal Cells - immunology Stromal Cells - metabolism Thymus Gland - cytology Thymus Gland - immunology Thymus Gland - metabolism Zinc Finger Protein Gli3
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