Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides

Similar to mammalian species, chickens show marked immunological responses to CpG oligodeoxynucleotides (ODNs) both in vivo and in vitro. In mammals, the receptor for ODNs has been demonstrated to be TLR9; however, an orthologue to mammalian TLR9 is absent in the chicken genome. In this study, chick...

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Veröffentlicht in:	Molecular immunology 2009-09, Vol.46 (15), p.3163-3170
Hauptverfasser:	Brownlie, Robert, Zhu, Jianzhong, Allan, Brenda, Mutwiri, George K., Babiuk, Lorne A., Potter, Andrew, Griebel, Philip
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Amino Acid Sequence Animals Cell Line Chicken Chickens - immunology Chickens - microbiology CpG oligodeoxynucleotide HD11 Humans Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Molecular Sequence Data NF-kappa B - agonists NF-kappa B - immunology NF-kappa B - metabolism Oligodeoxyribonucleotides - immunology Oligodeoxyribonucleotides - pharmacology RNA Interference - immunology Sequence Alignment TLR21 TLR9 Toll-like receptor Toll-Like Receptor 9 - drug effects Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - immunology
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