Mitochondrial Permeability Transition Pore Opening as a Promising Therapeutic Target in Cardiac Diseases

In addition to their central role in ATP synthesis, mitochondria play a critical role in cell death. Oxidative stress accompanied by calcium overload, ATP depletion, and elevated phosphate levels induces mitochondrial permeability transition (MPT) with formation of nonspecific MPT pores (MPTP) in th...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2009-09, Vol.330 (3), p.670-678
Hauptverfasser:	Javadov, Sabzali, Karmazyn, Morris, Escobales, Nelson
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiovascular Agents - pharmacology Cardiovascular Agents - therapeutic use Heart Diseases - drug therapy Heart Failure - drug therapy Heart Failure - physiopathology Humans Mitochondria - chemistry Mitochondria - drug effects Mitochondrial Membrane Transport Proteins - chemistry Mitochondrial Membrane Transport Proteins - drug effects Reperfusion Injury - drug therapy Reperfusion Injury - physiopathology
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