Effect of Glycemic Control on Left Ventricular Diastolic Function in Type 1 Diabetes Mellitus
Left ventricular (LV) diastolic dysfunction is a main feature of diabetic heart disease. The aim of this prospective study was to evaluate the influence of glycemic control on diastolic function in type 1 diabetes mellitus. Thirty-six normotensive (24-hour blood pressure 7%) type 1 diabetes, without...
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| Veröffentlicht in: | The American journal of cardiology 2006, Vol.97 (1), p.71-76 |
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| creator | Grandi, Anna M. Piantanida, Eliana Franzetti, Ivano Bernasconi, Matteo Maresca, Andrea Marnini, Patrizio Guasti, Luigina Venco, Achille |
| description | Left ventricular (LV) diastolic dysfunction is a main feature of diabetic heart disease. The aim of this prospective study was to evaluate the influence of glycemic control on diastolic function in type 1 diabetes mellitus. Thirty-six normotensive (24-hour blood pressure 7%) type 1 diabetes, without clinically detectable heart disease, were enrolled. After the basal evaluation, insulin therapy was modified to improve glycemic control. Glycated hemoglobin, LV echocardiography, 24-hour blood pressure monitoring, and laboratory tests were repeated after 6 months in all patients and after 12 months in 27 patients. At the basal evaluation, LV anatomy and systolic function were normal in all, and diastolic function was impaired in 14 patients. After 6 months, the mean values of body mass index, 24-hour blood pressure, and LV anatomy and systolic function were unchanged; mean glycated hemoglobin was decreased (p |
| doi_str_mv | 10.1016/j.amjcard.2005.07.110 |
| format | Article |
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The aim of this prospective study was to evaluate the influence of glycemic control on diastolic function in type 1 diabetes mellitus. Thirty-six normotensive (24-hour blood pressure <130/80 mm Hg) subjects with inadequately controlled (glycated hemoglobin >7%) type 1 diabetes, without clinically detectable heart disease, were enrolled. After the basal evaluation, insulin therapy was modified to improve glycemic control. Glycated hemoglobin, LV echocardiography, 24-hour blood pressure monitoring, and laboratory tests were repeated after 6 months in all patients and after 12 months in 27 patients. At the basal evaluation, LV anatomy and systolic function were normal in all, and diastolic function was impaired in 14 patients. After 6 months, the mean values of body mass index, 24-hour blood pressure, and LV anatomy and systolic function were unchanged; mean glycated hemoglobin was decreased (p <0.001), and mean values of diastolic parameters were significantly improved. After 12 months, the mean values of all blood pressure, metabolic, and LV parameters were unchanged. Percent changes of diastolic parameters were inversely correlated with percent changes of glycated hemoglobin, considering changes from the basal to the 6-month evaluation, as well as changes from the 6- to the 12-month evaluation. In conclusion, in normotensive patients with type 1 diabetes, a close relation was found between glycemic control and LV diastolic function, which improves when glycemic control improves. Therefore, diastolic dysfunction can be prevented or reversed, at least partly, by tight glycemic control.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2005.07.110</identifier><identifier>PMID: 16377287</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Blood Glucose - analysis ; Blood Pressure Monitoring, Ambulatory ; Body Mass Index ; Cardiology. Vascular system ; Cardiovascular disease ; Diabetes ; Diabetes Mellitus, Type 1 - drug therapy ; Diabetes Mellitus, Type 1 - physiopathology ; Diabetes. Impaired glucose tolerance ; Diastole - physiology ; Echocardiography ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Follow-Up Studies ; Glycated Hemoglobin A - analysis ; Glycemic index ; Hemoglobin ; Humans ; Hypoglycemic Agents - therapeutic use ; Image Processing, Computer-Assisted ; Insulin - therapeutic use ; Male ; Medical sciences ; Prospective Studies ; Systole - physiology ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Dysfunction, Left - therapy</subject><ispartof>The American journal of cardiology, 2006, Vol.97 (1), p.71-76</ispartof><rights>2006 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. 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The aim of this prospective study was to evaluate the influence of glycemic control on diastolic function in type 1 diabetes mellitus. Thirty-six normotensive (24-hour blood pressure <130/80 mm Hg) subjects with inadequately controlled (glycated hemoglobin >7%) type 1 diabetes, without clinically detectable heart disease, were enrolled. After the basal evaluation, insulin therapy was modified to improve glycemic control. Glycated hemoglobin, LV echocardiography, 24-hour blood pressure monitoring, and laboratory tests were repeated after 6 months in all patients and after 12 months in 27 patients. At the basal evaluation, LV anatomy and systolic function were normal in all, and diastolic function was impaired in 14 patients. After 6 months, the mean values of body mass index, 24-hour blood pressure, and LV anatomy and systolic function were unchanged; mean glycated hemoglobin was decreased (p <0.001), and mean values of diastolic parameters were significantly improved. After 12 months, the mean values of all blood pressure, metabolic, and LV parameters were unchanged. Percent changes of diastolic parameters were inversely correlated with percent changes of glycated hemoglobin, considering changes from the basal to the 6-month evaluation, as well as changes from the 6- to the 12-month evaluation. In conclusion, in normotensive patients with type 1 diabetes, a close relation was found between glycemic control and LV diastolic function, which improves when glycemic control improves. Therefore, diastolic dysfunction can be prevented or reversed, at least partly, by tight glycemic control.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Blood Pressure Monitoring, Ambulatory</subject><subject>Body Mass Index</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diastole - physiology</subject><subject>Echocardiography</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Glycemic index</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Image Processing, Computer-Assisted</subject><subject>Insulin - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Prospective Studies</subject><subject>Systole - physiology</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><subject>Ventricular Dysfunction, Left - therapy</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpaLZpf0KLKLQ3OxpZH_aphG2SFjb0kvZWhFYeg4xtbSW7sP8-2q4h0EtPwzDPDA_vEPIOWAkM1HVf2rF3NrYlZ0yWTJcA7AXZQK2bAhqoXpINY4wXDYjmkrxOqc8tgFSvyCWoSmte6w35ddt16GYaOno_HB2O3tFtmOYYBhomusNupj8x994tg430i7dpDkOm7pbJzT4zfqKPxwNSOA33OGOiDzgMfl7SG3LR2SHh27VekR93t4_br8Xu-_237c2ucKJWc5FNnKwUt1xyAS1yqKHdNxpFzWW9z66C2ayuO2klcsVarawQHQjOpbO2uiKfzncPMfxeMM1m9MllCTthWJJRWtZNI2QGP_wD9mGJU3YzvGKVqjWwDMkz5GJIKWJnDtGPNh4NMHMK3_RmDd-cwjdMG_i79349vuxHbJ-31rQz8HEFbHJ26KKdnE_PnBZc1eLEfT5zmDP74zGa5DxODlsf87NMG_x_VJ4Aw-2isw</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Grandi, Anna M.</creator><creator>Piantanida, Eliana</creator><creator>Franzetti, Ivano</creator><creator>Bernasconi, Matteo</creator><creator>Maresca, Andrea</creator><creator>Marnini, Patrizio</creator><creator>Guasti, Luigina</creator><creator>Venco, Achille</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Effect of Glycemic Control on Left Ventricular Diastolic Function in Type 1 Diabetes Mellitus</title><author>Grandi, Anna M. ; Piantanida, Eliana ; Franzetti, Ivano ; Bernasconi, Matteo ; Maresca, Andrea ; Marnini, Patrizio ; Guasti, Luigina ; Venco, Achille</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-287c5362a25241de2181db97e48258b37740a1157f5a5e260d76a44f14225caa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Blood Pressure Monitoring, Ambulatory</topic><topic>Body Mass Index</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - drug therapy</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diastole - physiology</topic><topic>Echocardiography</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Glycemic index</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Image Processing, Computer-Assisted</topic><topic>Insulin - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Prospective Studies</topic><topic>Systole - physiology</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><topic>Ventricular Dysfunction, Left - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grandi, Anna M.</creatorcontrib><creatorcontrib>Piantanida, Eliana</creatorcontrib><creatorcontrib>Franzetti, Ivano</creatorcontrib><creatorcontrib>Bernasconi, Matteo</creatorcontrib><creatorcontrib>Maresca, Andrea</creatorcontrib><creatorcontrib>Marnini, Patrizio</creatorcontrib><creatorcontrib>Guasti, Luigina</creatorcontrib><creatorcontrib>Venco, Achille</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grandi, Anna M.</au><au>Piantanida, Eliana</au><au>Franzetti, Ivano</au><au>Bernasconi, Matteo</au><au>Maresca, Andrea</au><au>Marnini, Patrizio</au><au>Guasti, Luigina</au><au>Venco, Achille</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Glycemic Control on Left Ventricular Diastolic Function in Type 1 Diabetes Mellitus</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2006</date><risdate>2006</risdate><volume>97</volume><issue>1</issue><spage>71</spage><epage>76</epage><pages>71-76</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Left ventricular (LV) diastolic dysfunction is a main feature of diabetic heart disease. The aim of this prospective study was to evaluate the influence of glycemic control on diastolic function in type 1 diabetes mellitus. Thirty-six normotensive (24-hour blood pressure <130/80 mm Hg) subjects with inadequately controlled (glycated hemoglobin >7%) type 1 diabetes, without clinically detectable heart disease, were enrolled. After the basal evaluation, insulin therapy was modified to improve glycemic control. Glycated hemoglobin, LV echocardiography, 24-hour blood pressure monitoring, and laboratory tests were repeated after 6 months in all patients and after 12 months in 27 patients. At the basal evaluation, LV anatomy and systolic function were normal in all, and diastolic function was impaired in 14 patients. After 6 months, the mean values of body mass index, 24-hour blood pressure, and LV anatomy and systolic function were unchanged; mean glycated hemoglobin was decreased (p <0.001), and mean values of diastolic parameters were significantly improved. After 12 months, the mean values of all blood pressure, metabolic, and LV parameters were unchanged. Percent changes of diastolic parameters were inversely correlated with percent changes of glycated hemoglobin, considering changes from the basal to the 6-month evaluation, as well as changes from the 6- to the 12-month evaluation. In conclusion, in normotensive patients with type 1 diabetes, a close relation was found between glycemic control and LV diastolic function, which improves when glycemic control improves. Therefore, diastolic dysfunction can be prevented or reversed, at least partly, by tight glycemic control.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16377287</pmid><doi>10.1016/j.amjcard.2005.07.110</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Blood Glucose - analysis Blood Pressure Monitoring, Ambulatory Body Mass Index Cardiology. Vascular system Cardiovascular disease Diabetes Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - physiopathology Diabetes. Impaired glucose tolerance Diastole - physiology Echocardiography Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Follow-Up Studies Glycated Hemoglobin A - analysis Glycemic index Hemoglobin Humans Hypoglycemic Agents - therapeutic use Image Processing, Computer-Assisted Insulin - therapeutic use Male Medical sciences Prospective Studies Systole - physiology Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - physiopathology Ventricular Dysfunction, Left - therapy |
| title | Effect of Glycemic Control on Left Ventricular Diastolic Function in Type 1 Diabetes Mellitus |
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