Rigidity and Flexibility of Dipeptidyl Peptidase IV: Crystal Structures of and Docking Experiments with DPIV

Dipeptidyl peptidase IV (DPIV) is an α,β-hydrolase-like serine exopeptidase, which removes dipeptides, preferentially with a C-terminal l-Pro residue, from the N terminus of longer peptide substrates. Previously, we determined the tetrameric 1.8 Å crystal structure of native porcine DPIV. Each monom...

Ausführliche Beschreibung