Porcine liver-expressed antimicrobial peptides, hepcidin and LEAP-2: cloning and induction by bacterial infection

Hepcidin is a liver-expressed iron-regulating hormone that also is an antimicrobial peptide. Here we report the full-length cDNA sequences of porcine hepcidin and liver-expressed antimicrobial peptide-2 (LEAP-2). Porcine hepcidin and LEAP-2 cDNA sequences contain 411 and 525 bp, and encode predicted...

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Veröffentlicht in:	Developmental and comparative immunology 2006, Vol.30 (4), p.357-366
Hauptverfasser:	Sang, Yongming, Ramanathan, Balaji, Minton, J. Ernest, Ross, Chris R., Blecha, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antimicrobial Cationic Peptides - biosynthesis Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - genetics Antimicrobial peptide Base Sequence Cloning, Molecular DNA, Complementary - genetics Hepcidin, LEAP Hepcidins Humans Innate immunity Liver - metabolism Molecular Sequence Data Organ Specificity RNA, Messenger - genetics RNA, Messenger - metabolism Salmonella enterica - physiology Salmonella Infections - genetics Salmonella Infections - microbiology Sequence Alignment Sequence Homology, Amino Acid Sus scrofa Sus scrofa - genetics
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