Hyperglycemia increases superoxide production in the CA1 pyramidal neurons after global cerebral ischemia

Transient global cerebral ischemia results in selective neuronal death in the vulnerable hippocampal CA1 pyramidal neurons in a delayed manner. Hyperglycemia accelerates and exacerbates neuronal damage in this region. The object of this study was to determine whether hyperglycemia-enhanced damage is...

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Veröffentlicht in:	Neuroscience letters 2006-01, Vol.393 (2), p.119-121
Hauptverfasser:	Muranyi, Marianna, Li, Ping-An
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biological and medical sciences Brain Ischemia - enzymology Brain Ischemia - pathology Cerebral ischemia Dihydroethidine Disease Models, Animal Ethidium - analogs & derivatives Ethidium - metabolism Fluorescent Antibody Technique - methods Free radicals Fundamental and applied biological sciences. Psychology Glial Fibrillary Acidic Protein - metabolism Hippocampus - pathology Hyperglycemia Hyperglycemia - enzymology Hyperglycemia - pathology Immunohistochemistry Male Medical sciences Neurology Phosphopyruvate Hydratase - metabolism Pyramidal Cells - enzymology Rats Rats, Wistar Superoxide Superoxides - metabolism Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs
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